A5019233921- Signaling Pathways in Disease
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Virus-based gene therapy research
- Heat shock proteins research
- Animal Virus Infections Studies
- Glioma Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- FOXO transcription factor regulation
- Virology and Viral Diseases
- Peptidase Inhibition and Analysis
- interferon and immune responses
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
National Institute of Infectious Diseases
2008-2025
Yokohama City University
2015-2024
Yokohama City University Medical Center
2006-2024
Yokohama City University Hospital
2010-2023
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2014
National Institutes of Health
2008-2009
Beth Israel Deaconess Medical Center
2001-2006
Harvard University
2002-2006
Taiho Pharmaceutical (Japan)
2006
National Defense Medical College
2001-2003
Lan Lan, MD; Dan Xu, Guangming Ye, Chen Xia, MS; Shaokang Wang, Yirong Li, MD, PhD; Haibo PhD
In the 2016/2017 winter season in Japan, HuNoV GII.P16-GII.2 strains (2016 strains) emerged and caused large outbreaks of acute gastroenteritis. To better understand outbreaks, we examined molecular evolution VP1 gene RdRp region 2016 from patients by studying their time-scale evolutionary phylogeny, positive/negative selection, conformational epitopes, phylodynamics. The phylogeny suggested that common ancestors diverged 2006 1999, respectively, strain was progeny a pre-2016 GII.2. rates...
Chronic hepatitis B virus (HBV) infection is a major public health problem worldwide. Although nucleos(t)ide analogs inhibiting viral reverse transcriptase are clinically available as anti-HBV agents, emergence of drug-resistant viruses highlights the need for new agents interfering with other targets. Here we report that cyclosporin A (CsA) can inhibit HBV entry into cultured hepatocytes. The effect CsA was independent binding to cyclophilin and calcineurin. Rather, blockade correlated...
Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for hepatitis B virus (HBV) entry. However, the susceptibility of NTCP-expressing cells to HBV diverse depending on culture condition. Stimulation with epidermal growth factor (EGF) was found potentiate infection. Here, we show that EGF (EGFR) plays critical role in virion internalization. In EGFR-knockdown cells, or its preS1-specific fluorescence peptide attached surface, but internalization attenuated....
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Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function subset these phosphorylated regulated by the prolyl isomerase Pin1 through isomerization Ser/Thr-Pro bonds. Although young −/− mice have been previously shown to develop normally, we show here that they displayed range cell-proliferative abnormalities, including decreased body weight testicular retinal atrophies. Furthermore, in adult females, breast...
Oncogenes Neu/HER2/ErbB2 and Ras can induce mammary tumorigenesis via upregulation of cyclin D1. One major regulatory mechanism in these oncogenic signaling pathways is phosphorylation serines or threonines preceding proline (pSer/Thr-Pro). Interestingly, the pSer/Thr-Pro motifs proteins exist two completely distinct cis trans conformations, whose conversion catalyzed specifically by essential prolyl isomerase Pin1. By isomerizing bonds, Pin1 regulate conformation function certain...
DNA damage leads to stabilization and accumulation of p53, which plays a pivotal role in transcriptional activation p21 cell cycle arrest. The increase p53 stability depends critically on its phosphorylation serine/threonine residues, including those preceding proline (Ser(P)/Thr-Pro). Ser(P)/Thr-Pro moiety exists the two distinct cis trans conformations their conversion is catalyzed specifically by prolyl isomerase Pin1. Pin1 regulates conformation function certain phosphorylated proteins...
Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by lack infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherited genetic background donor, and evaluated its application modeling HBV exploring virus–host interactions. To establish hiPSC-LO, cultured hiPSC-derived endodermal, mesenchymal, endothelial cells with...
Interferon regulatory factor-5 (IRF5), a transcription factor critical for the induction of innate immune responses, contributes to pathogenesis autoimmune disease systemic lupus erythematosus (SLE) in humans and mice. Lyn, Src family kinase, is also implicated human SLE, Lyn-deficient mice develop an SLE-like disease. Here, we found that Lyn physically interacted with IRF5 inhibit ubiquitination phosphorylation TLR-MyD88 pathway, thereby suppressing transcriptional activity manner...
Weaver syndrome (WS) is a rare congenital overgrowth disorder caused by heterozygous mutations in EZH2 (enhancer of zeste homolog 2) or EED (embryonic ectoderm development). and are core components the polycomb repressive complex 2 (PRC2), which possesses histone methyltransferase activity catalyzes trimethylation H3 at lysine 27. Here, we analyzed eight probands with clinically suspected WS whole-exome sequencing identified three mutations: 25.4-kb deletion partially involving CUL1...
Autophagy has been linked to a wide range of functions, including degradative process that defends host cells against pathogens. Although the involvement autophagy in HBV infection become apparent, it remains unknown whether selective plays critical role restriction. Here, we report member galectin family, GAL9, directs autophagic degradation HBc. BRET screening revealed GAL9 interacts with HBc living cells. Ectopic expression induces formation HBc-containing cytoplasmic puncta through...