A5046267754- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Signaling Pathways in Disease
- Virus-based gene therapy research
- S100 Proteins and Annexins
- HIV Research and Treatment
- Virology and Viral Diseases
- Mesenchymal stem cell research
- Mosquito-borne diseases and control
- Dermatologic Treatments and Research
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Cardiac Arrest and Resuscitation
- Bone Tissue Engineering Materials
- Contact Dermatitis and Allergies
- Renal and related cancers
- Renal cell carcinoma treatment
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
Beth Israel Deaconess Medical Center
2013-2023
Harvard University
2013-2023
Translational Therapeutics (United States)
2015-2023
Cancer Research Institute
2021
Shimane University
2017
Yokohama City University
2008-2011
Oita Prefectural Board of Education
2011
National Institute of Biomedical Innovation, Health and Nutrition
2008
Okayama University
1993-2002
Gunma University
1997-1998
The mechanisms underpinning concussion, traumatic brain injury, and chronic encephalopathy, the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in acute-subacute period after mild closed-head impact injury found astrocytosis, myelinated axonopathy, microvascular perivascular neuroinflammation, phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral that uses momentum...
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) Alzheimer's disease. We previously showed that cis phosphorylated tau (cis P-tau), but not trans form, contributes to pathology functional impairment in an animal model severe TBI. Here we found human samples obtained post TBI due a variety causes, P-tau induced cortical axons cerebrospinal fluid positively correlates axonal clinical...
Reducing brain blood flow induces toxic but druggable cis P-tau that drives progressive neurodegeneration and memory loss in mice.
The prominent characteristics of pluripotent stem cells are their unique capacity to self-renew and pluripotency. Although cell proliferation is maintained by specific intracellular phosphorylation signaling events, it has not been well characterized how the resulting phosphorylated proteins subsequently regulated. We here report that peptidylprolyl isomerase Pin1 indispensable for self-renewal maintenance via regulation Oct4 other substrates. expression was found be up-regulated upon...
Temporary support of a damaged liver by bioartificial (BAL) devise is promising approach for the treatment acute failure. Although human primary hepatocytes are an ideal source hepatic function in BAL, shortage livers available hepatocyte isolation limiting factor use this modality. A clonal cell line that can grow economically culture and exhibit liver-specific functions should be attractive solution to problem.To test alternative, fetal were immortalized using Simian virus 40 large T...
Abstract Background Adenovirus type 5 (Ad5) is widely used as a vehicle for vaccine delivery in the treatment of infectious disease and cancer. However, efficacy Ad5 vectors has been limited humans because exposure to infections results most adults having neutralizing antibodies against Ad5. To overcome this limitation, hexon epitope present fifth hypervariable region was modified. Methods evaluate ability encoding HIV env protein induce Ag‐specific immune responses face pre‐existing...
Abstract Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally may trigger dementia later in life mothers their offspring. However, etiological drivers remain elusive. Cis P-tau an early driver blood biomarker pre-clinical Alzheimer’s after vascular or traumatic brain injury, which can be targeted by stereo-specific antibody, with clinical trials ongoing. Here we find significant cis placenta serum PE patients, primary human trophoblasts exposed to hypoxia sera from...
The addition of L-ascorbic acid 2-phosphate (Asc 2-P), which is active and stable under a conventional culture condition, could render dermal fibroblasts to the organization dermis-like structure on plastic dish without any prior treatment. cell layer was composed multilayered surrounded by dense extracellular matrices. Confocal microscopic examination disclosed that in upper were spindle-shaped those lower polygonal. Electron revealed accumulation mature collagen fibrils intercellular...
Using 2-dimensional gel electrophoresis, we previously demonstrated that the S100C protein remarkably decreased after immortalization of normal human fibroblasts, and this caused growth inhibition tumor cells when forcibly expressed in these cells, suggesting plays a significant role suppression. The present study was carried out to determine what type tissues express protein, and, subsequently, whether content changes have been transformed into cancer cells. We found ductal various were...
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A high incidence of renal adenocarcinoma has been observed in rats treated with ferric nitrilotriacetate (Fe‐NTA) but not aluminum (Al‐NTA). Transforming growth factor (TGF)‐α is one the several cytokines that known to be expressed human and rat adenocarcinomas. However, its role neoplastic transformation still questionable. Therefore, we investigated effect repeated Fe‐NTA Al‐NTA administration on TGF‐α expression. Male Wistar were given (n = 16, 5–10 mg FeAg) 19, 1–2 Al/kg) i.p., three...