A5022086187- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- CNS Lymphoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Brain Metastases and Treatment
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Eicosanoids and Hypertension Pharmacology
- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- Hormonal Regulation and Hypertension
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Angiogenesis and VEGF in Cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Lymphatic System and Diseases
- Hedgehog Signaling Pathway Studies
- Traumatic Brain Injury and Neurovascular Disturbances
Niigata University
2014-2025
Northwestern University
2022-2024
University of Alabama at Birmingham
2023-2024
Children's of Alabama
2024
Lurie Children's Hospital
2022-2023
Daiichi-Sankyo (Japan)
2017-2021
Toyooka Hospital
2021
Tongde Hospital of Zhejiang Province
2020
Akita Red Cross Hospital
2015-2016
Yokohama City University
2016
Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation differentiation. Enhancer of zeste homolog (EZH2) or its close EZH1 functions as a catalytic subunit PRC2, so there are two PRC2 complexes containing either EZH2 EZH1. Tumorigenic synthetic lethality with some subunits SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling have been observed. However, little is known about the function in tumorigenesis....
Epithelioid glioblastoma is a rare aggressive variant of (GBM) characterized by dismal prognosis about 6 months and frequent leptomeningeal dissemination. A recent study has revealed that 50% epithelioid GBMs harbor three genetic alterations – BRAF V600E mutation, TERT promoter mutations, homozygous deletions CDKN2A/2B. Emerging evidence support the effectiveness targeted therapies for brain tumors with mutation. Here we describe dramatic radiographical response to combined therapy MEK...
Small cell lung cancer (SCLC), accounting for around 13% of all cancers, often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. The POU class 2 homeobox 3 (POU2F3) is a master regulator tuft identity defines the SCLC-P subtype that lacks neuroendocrine markers. Here, we have identified previously uncharacterized protein, C11orf53, which coexpressed with POU2F3 both SCLC lines patient samples. Mechanistically, C11orf53 directly interacts recruited to...
ABSTRACT Introduction Leptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A K27M‐mutant droplets cerebrospinal fluid (CSF) circulating tumor deoxyribonucleic acid (ctDNA) could be a biomarker for LMD DMGs. Methods Twenty‐five CSF samples were obtained from 22 DMG patients. Histological confirmation of K27M mutation was 10...
Biopsy is the gold standard for diagnosis of primary CNS lymphoma (PCNSL). However, surgical biopsy has problems morbidity related to hemorrhagic complications and false-negative findings, so safer more reliable diagnostic methods are required. The aim this study detect MYD88 mutation, an important driver in cerebrospinal fluid (CSF) patients with lymphoma.Twenty-six (20 six relapse from systemic lymphoma) were studied. We extracted cell-free DNA (cfDNA) CSF by lumbar puncture. cfDNA was 1...
AIM:To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer (CRC) at multiple Japanese institutions. METHODS:We identified 362 diagnosed from January 1, 2002 to December 31, 2012 Yokohama Clinical Oncology Group's department of gastroenterological surgery.Among them, 234 stage Ⅱ/Ⅲ disease who had undergone surgical resection their primary lesions were analyzed, retrospectively.We report outcomes, risk for recurrence, factors....
Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), each potentially a possible therapeutic target treating AT/RT. We, therefore, determined whether targeting distinct histone modifier activities was effective approach The effects inhibition on modification, cell proliferation, invasion were analyzed by immunoblotting, MTS assay, colony formation assay. RNA- chromatin immunoprecipitation-sequencing used to...
Primary central nervous system lymphoma (PCNSL) is an isolated type of the and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations MYD88 CD79B in immunocompetent PCNSL, whereas LMP1 activation commonly observed Epstein-Barr virus (EBV)-positive PCNSL. However, lack clinically representative preclinical models hampered our understanding pathogenic mechanisms by which genetic aberrations drive PCNSL disease phenotypes. Here,...
Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes DNA hypomethylation, one of which is a frequent lack O6-methyl-guanine-DNA methyltransferase (MGMT) promoter methylation, resulting increased MGMT expression. We established the NGT16 cell line with HIST1H3B K27M and ACVR1 G328E from DMG patient used this other lines H3F3A mutation (SF7761, SF8628, JHH-DIPG1) analyze protein...
High-grade gliomas (HGG) are deadly diseases for both adult and pediatric patients. Recently, it has been shown that neuronal activity promotes the progression of multiple subgroups HGG. However, epigenetic mechanisms govern this process remain elusive. Here we report chromatin remodeler chromodomain helicase DNA-binding protein 2 (CHD2) regulates neuron-glioma interactions in diffuse midline glioma (DMG) characterized by onco-histone H3.1K27M. Depletion CHD2 H3.1K27M DMG cells compromises...
Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased screening, we found Schlafen family member 11 (SLFN11), which is known to improve response DNA damaging agents various cancers, be one of the top prognostic markers medulloblastomas. Hence, explored expression functions SLFN11 medulloblastoma.SLFN11 for each subgroup...
Most dural arteriovenous fistula (DAVF) in superior sagittal sinus (SSS) requires multimodal treatment. Onyx embolization is useful for DAVF; however, scalp artery has cast extrusion risk.A 59-year-old male presented with involuntary movements of both legs and progressive dementia. Cerebral angiography demonstrated the DAVF SSS fed by bilateral superficial temporal, occipital, middle meningeal arteries. The posterior was thrombosed, main drainers were cortical veins. Combined treatment...
Epigenetic status-altering mutations in chromatin-modifying enzymes are a feature of human diseases, including many cancers. However, the functional outcomes and cellular dependencies arising from these remain unresolved. In this study, we investigated dependencies, or vulnerabilities, that arise when enhancer function is compromised by loss frequently mutated COMPASS family members MLL3 MLL4. CRISPR dropout screens MLL3/4-depleted mouse embryonic stem cells (mESCs) revealed synthetic...
Recent studies have suggested the feasibility of detecting H3K27M mutations in cerebrospinal fluid diffuse midline glioma (DMG) patients. However, from patients these were collected mainly during biopsy, ventriculo-peritoneal shunt procedures or postmortem. We assessed circulating tumor DNA (ctDNA) extracted (CSF) and plasma a series 12 radiographically suspected and/or pathologically confirmed for H3F3A K27M mutation using digital droplet PCR. In 10 patients, CSF was obtained by lumbar...
Despite advances in molecular imaging, preoperative diagnosis of astrocytomas and oligodendrogliomas can be challenging. In the present study, we assessed whether 7T SWI used to distinguish malignant grading gliomas is possible.7T was performed on 21 patients with before surgery optimization for sharp visualization corticomedullary junction. Scoring cortical thickening displacement medullary vessels, characteristic oligodendroglial tumors, tapering, astrocytic performed. Additionally,...