Tara Barron
A5000044473- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
- Neuroblastoma Research and Treatments
- Neonatal and fetal brain pathology
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Memory and Neural Computing
- CRISPR and Genetic Engineering
- Neuroendocrine regulation and behavior
- interferon and immune responses
- Ion channel regulation and function
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
Stanford University
2021-2025
Palo Alto University
2021
The University of Texas Health Science Center at San Antonio
2017-2020
The University of Texas Health Science Center at Houston
2019
Integrative Health Technologies (United States)
2019
Abstract The role of the nervous system in regulation cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor 1–3 (BDNF), also electrophysiologically functional neuron-to-glioma synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors 4,5 . consequent glioma cell membrane depolarization proliferation 4,6 healthy brain,...
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a cellular hierarchy along the interneuron lineage development continuum, revealing that DHG-H3G34 mirror spatial patterns of progenitor streams surrounding nests, as seen during human development. Integrating these findings with genome-wide...
Abstract Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized different brain regions. The roles oligodendroglial voltage-activated Na + channels (Na v ) electrical excitability relation to myelinating stage controversial, although is potentially important promoting axon myelination. Here we show spiking their role auditory brainstem. A subpopulation...
High-grade gliomas (HGG) are deadly diseases for both adult and pediatric patients. Recently, it has been shown that neuronal activity promotes the progression of multiple subgroups HGG. However, epigenetic mechanisms govern this process remain elusive. Here we report chromatin remodeler chromodomain helicase DNA-binding protein 2 (CHD2) regulates neuron-glioma interactions in diffuse midline glioma (DMG) characterized by onco-histone H3.1K27M. Depletion CHD2 H3.1K27M DMG cells compromises...
Abstract Pediatric high-grade gliomas are the leading cause of brain cancer-related death in children. High-grade include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline (DMG) such as intrinsic pontine glioma (DIPG) hemispheric gliomas. Neuronal activity drives progression both through paracrine signaling 1,2 direct neuron-to-glioma synapses 3–5 . Glutamatergic, AMPA receptor-dependent between neurons malignant cells have been...
The roles of myelin in maintaining axonal integrity and action potential (AP) propagation are well established, but its role synapse maintenance neurotransmission remains largely understudied. Here, we investigated how Purkinje axon myelination regulates synaptic transmission the to deep cerebellar nuclei (DCN) synapses using Long Evans Shaker (LES) rat, which lacks compact thus displays severe locomotion deficits. DCN neurons fired spontaneous potentials (APs), whose frequencies were...
Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca2+ rise is critical for axon myelination development. Here, we investigate signaling factors sources of in OLs the mouse brainstem. Glutamate puff or fiber stimulation induces a pre-myelinating OLs, which primarily mediated by -permeable AMPA receptors. During glutamate application, inward currents via receptors elevated extracellular K+ caused increased neuronal activity collectively lead depolarization,...
The nervous system plays an increasingly appreciated role in the regulation of cancer. In malignant gliomas, neuronal activity drives tumor progression not only through paracrine signaling factors such as neuroligin-3 and brain-derived neurotrophic factor (BDNF) 1–3 , but also electrophysiologically functional neuron-to-glioma synapses 4–6 . Malignant are mediated by calcium-permeable AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors both pediatric adult high-grade...
Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal of Purkinje cells, the primary output cells cortex, crucial for structure function cerebellum. However, morphological electrophysiological features at different gestational ages, effects neonatal intensive care unit (NICU) experience on are unexplored. Utilizing non-human primate baboon cerebellum, we investigated cell during last trimester pregnancy effect NICU following premature birth...
Abstract High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline (DMG) such as intrinsic pontine glioma (DIPG) hemispheric high-grade gliomas. Neuronal activity drives progression both through paracrine signaling direct neuron-to-glioma synapses. Glutamatergic, AMPA receptor-dependent synapses between neurons malignant cells have been demonstrated in pediatric adult gliomas, but mediated other neurotransmitters remain...
<div>Abstract<p>High-grade gliomas (HGG) are deadly diseases for both adult and pediatric patients. Recently, it has been shown that neuronal activity promotes the progression of multiple subgroups HGG. However, epigenetic mechanisms govern this process remain elusive. Here we report chromatin remodeler chromodomain helicase DNA-binding protein 2 (CHD2) regulates neuron–glioma interactions in diffuse midline glioma (DMG) characterized by onco-histone H3.1K27M. Depletion CHD2...
<p>FOSL1 colocalizes with CHD2 to regulate cell viability and gene expression.</p>
<p>CHD2 binds to the gene regulatory elements of axon-guidance and synaptic genes.</p>
<p>Validation of hits from CRISPR/Cas9 screens.</p>
<div>Abstract<p>High-grade gliomas (HGG) are deadly diseases for both adult and pediatric patients. Recently, it has been shown that neuronal activity promotes the progression of multiple subgroups HGG. However, epigenetic mechanisms govern this process remain elusive. Here we report chromatin remodeler chromodomain helicase DNA-binding protein 2 (CHD2) regulates neuron–glioma interactions in diffuse midline glioma (DMG) characterized by onco-histone H3.1K27M. Depletion CHD2...
<p>Calcium imaging in brain slices with SU-DIPG36 xenografts hippocampal CA1.</p>
<p>CHD2 regulates neuron-induced proliferation of H3.1K27M DMG cells.</p>