A5032429143- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Insect behavior and control techniques
- Circadian rhythm and melatonin
- Pharmaceutical Quality and Counterfeiting
- Sexual function and dysfunction studies
- Phytochemicals and Medicinal Plants
- Insect symbiosis and bacterial influences
- Prenatal Substance Exposure Effects
- Luminescence and Fluorescent Materials
- Soil and Unsaturated Flow
- Spaceflight effects on biology
- Neurogenesis and neuroplasticity mechanisms
- Agricultural risk and resilience
- SARS-CoV-2 detection and testing
- Agricultural Economics and Practices
- Neuroendocrine regulation and behavior
- Menstrual Health and Disorders
- Image Retrieval and Classification Techniques
- Nicotinic Acetylcholine Receptors Study
Stanford University
2025
Indian Institute of Technology Jammu
2023-2024
Creative Commons
2023
National Institute of Ayurveda
2023
University of Michigan–Ann Arbor
2020-2023
Pandit Deendayal Upadhyaya Shekhawati University
2023
CT Group Of Institutions
2022
University of Copenhagen
2014-2021
Indian Institute of Technology Mandi
2021
Yale University
2019
Herein we unveil the presence of a molecular fluorophore quinoxalino[2,3-<italic>b</italic>]phenazine-2,3-diamine (QXPDA) in colossal amount red emissive CNDs synthesized from <italic>o</italic>-phenylenediamine, well-known precursor molecule used for CND synthesis.
Dipteran or "true" flies occupy nearly every terrestrial habitat, and have evolved to feed upon a wide variety of sources including fruit, pollen, decomposing animal matter, even vertebrate blood. Here we analyze the molecular, genetic cellular basis odor response in tsetse fly Glossina morsitans, which feeds on blood humans their livestock, is vector deadly trypanosomes. The G. morsitans antenna contains specialized subtypes sensilla, some line sensory pit not found fruit Drosophila. We...
Circadian clocks regulate ∼24-h oscillations in gene expression, behavior, and physiology. While the genetic molecular mechanisms of circadian rhythms are well characterized, what remains poorly understood intracellular dynamics clock components how they affect rhythms. Here, we elucidate spatiotemporal organization core proteins genes Drosophila neurons. Using high-resolution imaging DNA-fluorescence situ hybridization techniques, demonstrate that (PERIOD CLOCK) organized into a few...
The endogenous cannabinoids (eCBs) influence the acute response to ethanol and development of tolerance, dependence relapse. Chronic alcohol exposure alters eCB levels Type 1 cannabinoid receptor (CB1) expression function in brain regions associated with addiction. CB1 inhibits GABA release, GABAergic dysregulation central nucleus amygdala (CeA) is critical transition dependence. We investigated possible disruptions signaling rat CeA transmission following intermittent exposure. In...
Nicotinic acetylcholine receptors (nAChRs) affect multiple physiological functions in the brain and their are modulated by regulatory proteins of Lynx family. Here, we report for first time a direct interaction protein LY6/PLAUR domain-containing 6 (Lypd6) with nAChRs human extracts, identifying Lypd6 as novel regulator nAChR function. Using cross-linking affinity purification from temporal cortical demonstrate that is synaptically enriched membrane-bound binds to subtypes brain....
The basolateral nucleus of the amygdala (BLA) is critical to pathophysiology anxiety-driven alcohol drinking and relapse. endogenous cannabinoid/type 1 cannabinoid receptor (eCB/CB1 ) system curbs BLA-driven anxiety stress responses via a retrograde negative feedback that inhibits neurotransmitter release, BLA CB1 activation reduces GABA release drives anxiogenesis. Additionally, decreased observed in abstinent alcoholic patients ethanol withdrawn rats. Here, we investigated potential...
Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on basis UV, IR, NMR spectroscopy, further supported mass spectroscopy. The result obtained confirms superiority method over classical heating one. molecular properties Lipinski rule five for determined Molinspiration. synthesized subsequently evaluated antioxidant activity. found in compliance with “Rule Five”,...
Significance Tsetse flies pose a major threat to the health and economy of sub-Saharan Africa. They transmit trypanosomes that cause African sleeping sickness in humans disease called nagana livestock. find their hosts large part through olfactory cues, but little is known about cellular basis olfaction these flies. We carried out systematic physiological analysis response tsetse antenna. identified 7 classes sensilla respond human or animal odors, CO 2 , pheromones, repellent. The...
Abstract Marijuana, which acts within the endocannabinoid (eCB) system as an agonist of cannabinoid type 1 receptor (CB1R), exhibits addictive properties and has powerful actions on state arousal organism. The laterodorsal tegmental nucleus (LDT), a component reticular activating system, is involved in cortical activation important development drug addiction‐associated behaviours. Therefore, eCBs might exert behavioural effects by LDT; however, it unknown whether have neurons this nucleus....
Recommendation systems can be considered as one of the most popular tools to raise profit and retain users. In fields Recommender are being used. The aim recommender system is that it suggests content for users based on their previous choices or what type taste they having. When there a need implementing an effective system, should always diverse in not supposed biased towards content. this perspective, content-based filtering will provide well-suited results user. This research study...
Hunger drives animals to search for food, a behavior that is heavily dependent on the olfactory system. The neuronal mechanism by which hunger modulates behavioral response towards food odor, however, not well understood. In this study, using single-fly assay and single-unit recording, we have demonstrated starved flies exhibit enhanced attraction an attractive ethyl acetate, via increased sensitization of receptor neurons (ORNs). These results suggest caused due sensitivity in ORNs.
As part of the brainstem reticular activating system, laterodorsal tegmentum (LDT) is a central player in regulating sleep, arousal, and motivated behaviors including addiction. The neuronal lipids within LDT that could regulate activity signaling are not fully characterized due, part, to complication presence fatty acid amide hydrolases (FAAH). To determine LDT, mouse brain slices at different stages development (16, 26 66 days) were exposed ex vivo FAAH inhibitor oleyl trifluoromethyl...
A BSTRACT Menstruation is a cyclic physiological process of uterine bleeding due to the shedding endometrium. normal menstrual cycle plays an essential role in maintaining woman’s health status during reproductive age. Premature menopause defined as cessation menstruation at or below age 40. ovarian failure (POF) when occurs before The prevalence premature insufficiency estimated 1% general population. present case report documents efficacy Ayurvedic medication female aged 24 years who had...
A selective and sensitive liquid chromatographic/tandem mass spectrometric method was developed validated for the matrix effect controlled estimation of sildenafil N-desmethyl in human plasma. The samples were extracted on solid-phase extraction cartridges chromatographed XTerra MS C18 5 µm (4.6 mm x 150 mm) column using isocratic mobile phase. over concentration range 5.00–1401.35 ng/mL 2.83–603.38 ng/mL sildenafil. parent to product ion transitions sildenafil, quetiapine m/z 475.10–283.30;...
ABSTRACT Circadian clocks regulate ∼24 hour oscillations in gene expression, behavior, and physiology. While the molecular neural mechanisms of circadian rhythms are well characterized, how cellular organization clock components controls regulation remains poorly understood. Here, we elucidate proteins by controlling spatiotemporal genes. Using high-resolution live imaging techniques demonstrate that Drosophila concentrated a few discrete foci organized at nuclear envelope; these results...