Derek Dang
A5020491193- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- 14-3-3 protein interactions
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Histone Deacetylase Inhibitors Research
- Adrenal and Paraganglionic Tumors
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Fetal and Pediatric Neurological Disorders
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Neonatal and fetal brain pathology
- Caveolin-1 and cellular processes
- Ferroptosis and cancer prognosis
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Medical Imaging Techniques and Applications
- Congenital heart defects research
- Autophagy in Disease and Therapy
- Meningioma and schwannoma management
- Cancer, Lipids, and Metabolism
University of Michigan
2018-2025
Seattle University
2017-2021
Abstract Niemann–Pick type C disease is a fatal, progressive neurodegenerative disorder caused by loss-of-function mutations in NPC1, multipass transmembrane glycoprotein essential for intracellular lipid trafficking. We sought to define the cellular machinery controlling degradation of most common disease-causing mutant, I1061T NPC1. show that this mutant degraded, part, proteasome following MARCH6-dependent ERAD. Unexpectedly, we demonstrate NPC1 also degraded recently described autophagic...
Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin.
FOXC1 loss contributes to Dandy-Walker malformation (DWM), a common human cerebellar malformation. Previously, we found that complete Foxc1 leads aberrations in proliferation, neuronal differentiation and migration the embryonic mouse cerebellum (<xref ref-type="bibr" rid="bib9">Haldipur et al., 2014</xref>). We now demonstrate hypomorphic mutant mice have granule Purkinje cell abnormalities causing subsequent disruptions postnatal foliation lamination. Particularly striking is...
H3K27M diffuse midline gliomas (DMG), including intrinsic pontine (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells. Here, we establish in vitro models that recapitulate DMG-OPC-like AC-like phenotypes perform transcriptomics, metabolomics, bioenergetic profiling to identify metabolic programs the different states. We then define strategies target vulnerabilities within...
Rhabdoid tumors (RTs) arise within (atypical teratoid/rhabdoid tumor [AT/RT]) or outside the brain (extra [e]CNS-RT) and are driven mainly by inactivation of SWItch/sucrose nonfermentable (SWI/SNF) complex subunit SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily B member 1 (SMARCB1). A pathognomonic hallmark RTs is heterogeneous multilineage differentiation, including anomalous neuronal differentiation in some eCNS-RTs. Because remodeling SWI/SNF regulates we...
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high prevalent, incurable, and routinely fatal. possess abnormal DNA methylation frequent β-catenin-activating mutations. Here, we demonstrated that maintained by balance between nuclear, β-catenin-containing complexes, the epigenome. On chromatin, β-catenin bound master adrenal transcription factor SF1 hijacked...
Abstract BACKGROUND MYC-driven Group-3 medulloblastomas (MB) are deadly and malignant pediatric brain cancers we sought to define actionable metabolic dependencies in these tumors. METHODS To identify uniquely upregulated genes MB, performed transcriptomic analysis on two previously published medulloblastoma RNA-seq datasets. elucidate the relationship between c-MYC/IDH1/DLAT assess impact tumor metabolism, transcriptional profiling of MB cell lines that were either untreated or subjected...
<p>Supplementary Information: Supplementary Figures 1-6 with Figure Legends, Table 1 (reference only), 2, Methods, References</p>
<p>Supplementary Table 1: NCI-H295R RNA-seq FPKM table, Related to Figures 2-4, 6.</p>
<p>Supplementary Information: Supplementary Figures 1-6 with Figure Legends, Table 1 (reference only), 2, Methods, References</p>
<p>Supplementary Table 1: NCI-H295R RNA-seq FPKM table, Related to Figures 2-4, 6.</p>
<div>Abstract<p>Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high prevalent, incurable, and routinely fatal. possess abnormal DNA methylation frequent β-catenin activating mutations. Here, we demonstrated that maintained by balance between nuclear, β-catenin-containing complexes the epigenome. On chromatin, bound master adrenal transcription factor SF1...
Abstract Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal cortex without curative medical therapies. CIMP-high an aggressive ACC molecular subtype defined by global CpG island hypermethylation with paradoxical activation differentiation (driven master transcription factor SF1) and stemness β-catenin). We show DNA redistributes histone methyltransferase EZH2 its mark, H3K27me3. inhibition remains lethal to cells, erasing transcriptional programs altering methylation. reconcile...
Abstract Medulloblastomas (MB) are the most common pediatric brain malignancy. Transcriptomic, genomic, and epigenomic insights have stratified these tumors into four distinct subtypes: SHH, WNT, Group 3 4. Of subtypes, bear worst prognosis. Each MB subtype is distinguished by their unique transcriptome profile epigenetic landscape. Metabolic reprogramming a hallmark of cancer allows cells to actively promote utilization nutrients support uncontrolled proliferation. We identified...
Abstract Ependymomas are fatal brain malignancies with very few treatment options. More than 70% of supratentorial (ST) ependymomas harbor fusions the zinc-finger containing, chromatin modifier ZFTA and transcriptional activator NF-κB signaling, RELA. Oncogene-driven metabolic reprogramming is a fundamental hallmark cancer that enables sustained tumor proliferation. ZFTA-RELA fusion protein essential for tumorigenesis our goal to determine how it drives metabolism in ST-ependymomas. To...
<div>Abstract<p>Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high prevalent, incurable, and routinely fatal. possess abnormal DNA methylation frequent β-catenin activating mutations. Here, we demonstrated that maintained by balance between nuclear, β-catenin-containing complexes the epigenome. On chromatin, bound master adrenal transcription factor SF1...
<p>Supplementary Table 1: NCI-H295R RNA-seq FPKM table, Related to Figures 2-4, 6.</p>
<div>Abstract<p>Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high prevalent, incurable, and routinely fatal. possess abnormal DNA methylation frequent β-catenin–activating mutations. Here, we demonstrated that maintained by balance between nuclear, β-catenin–containing complexes, the epigenome. On chromatin, β-catenin bound master adrenal transcription...