A5077877339- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Virus-based gene therapy research
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Titanium Alloys Microstructure and Properties
- Estrogen and related hormone effects
- Additive Manufacturing Materials and Processes
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Intermetallics and Advanced Alloy Properties
- Inertial Sensor and Navigation
- RNA Research and Splicing
- Renal and related cancers
Northwestern University
2015-2025
Midwestern University
2025
Northwest A&F University
2024
Northwestern Medicine
2022-2024
Dalian University of Technology
2020-2022
Dalian University
2021-2022
The Queen's Medical Research Institute
2021
University of Edinburgh
2021
Xinjiang Astronomical Observatory
2002-2021
Chinese Academy of Sciences
2021
Protein-coding genes account for only a small part of the human genome, whereas vast majority transcripts make up non-coding RNAs including long (lncRNAs). Accumulating evidence indicates that lncRNAs could play critical role in regulation cellular processes such as cell growth and apoptosis well cancer progression metastasis. LncRNA loc285194 was previously shown to be within tumor suppressor unit osteosarcoma suppress growth. However, it is unknown regarding loc285194. Moreover, underlying...
Understanding the mechanisms of androgen receptor (AR) activation in milieu low is critical to effective treatment castration-resistant prostate cancer (CRPC). Here, we report HOTAIR as an androgen-repressed lncRNA, and, such, it markedly upregulated following deprivation therapies and CRPC. We further demonstrate a distinct mode lncRNA-mediated gene regulation, wherein binds AR protein block its interaction with E3 ubiquitin ligase MDM2, thereby preventing ubiquitination degradation....
It is well known that upon stress, the level of tumor suppressor p53 remarkably elevated. However, despite extensive studies, underlying mechanism involving important inter-players for stress-induced regulation still not fully understood. We present evidence human lincRNA-RoR (RoR) a strong negative regulator p53. Unlike MDM2 causes degradation through ubiquitin-proteasome pathway, RoR suppresses translation direct interaction with heterogeneous nuclear ribonucleoprotein I (hnRNP I)....
Abstract Background The severity and frequency of drought are expected to increase substantially in the coming century dramatically reduce crop yields. Manipulation rhizosphere microbiomes is an emerging strategy for mitigating stress agroecosystems. However, little known about mechanisms underlying how drought-resistant plant recruitment specific fungi enhances adaptation drought-sensitive wheats. Here, we investigated microbial community assembly features functional profiles related wheats...
Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating efficacy of chemotherapeutics combined with radiation treating tumors high clinical relevance. In this study, we examined cyclin-dependent kinase 4/6 inhibitor palbociclib, when in combination human atypical teratoid rhabdoid tumor (ATRT) as well glioblastoma (GBM).Evaluation antitumor activity vitro was based upon results from cell proliferation assays,...
Castration-resistant prostate cancer (CRPC) that has developed resistance to the new-generation androgen receptor (AR) antagonist enzalutamide is a lethal disease. Transcriptome analysis of multiple models identified CXCR7, an atypical chemokine receptor, as one most upregulated genes in enzalutamide-resistant cells. AR directly repressed CXCR7 by binding enhancer 110 kb downstream gene and expression was restored upon deprivation. We demonstrate critical regulator sensitivity required for...
Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in humans and it has also been implicated tumorigenesis. However, the underlying mechanism of Linc-RoR-mediated gene expression cancer is poorly understood. The present study demonstrates that plays an oncogenic role part through regulation c-Myc expression. knockout (KO) suppresses cell proliferation tumor growth. In particular, KO causes significant decrease whereas re-expression restores level c-Myc....
Radiotherapy (RT) has long been and remains the only treatment option for diffuse intrinsic pontine glioma (DIPG). However, all patients show evidence of disease progression within months completing RT. No further clinical benefit achieved using alternative radiation strategies. Here, we tested hypothesis that histone demethylase inhibition by GSK-J4 enhances radiation-induced DNA damage, making it a potential radiosensitizer in DIPG.Experimental Design: We evaluated effects on genes...
Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), each potentially a possible therapeutic target treating AT/RT. We, therefore, determined whether targeting distinct histone modifier activities was effective approach The effects inhibition on modification, cell proliferation, invasion were analyzed by immunoblotting, MTS assay, colony formation assay. RNA- chromatin immunoprecipitation-sequencing used to...
Abstract Background: TIL cell therapy can induce durable disease regression in solid tumors. engineered with regulatable mbIL15 (cytoTIL15TM cells) demonstrate interleukin 2-independent expansion and function (Burga SITC 2023) lead to clinical responses (Amaria ASCO 2024). Furthermore, co-regulated expression of LIGHT show enhanced efficacy fibroblast-containing, immunologically cold tumors (Koscso AACR Chondrosarcomas are often mesenchymal stem-cell origin similar transcriptional signature...
Abstract Background: Presence of tumor infiltrating NK (TINK) cells linked to prognosis in many solid tumors, but their function is often constrained by the adverse microenvironment. Although promising antileukemia activity has been shown, exploitation adoptive cell therapy for still limited and unsatisfactory. Tumor MIC (MHC I chain related molecule) modulates TME contributes dysfunction, here we study role anti-MICA/B antibody TINK’s against sarcoma tumors. Because are prevalent human...
Oncoproteins from high-risk human papillomaviruses (HPV) downregulate the transcription of class I major histocompatibility complex (MHC-I) antigen presentation apparatus in tissue culture model systems. This could allow infected or transformed cells to evade adaptive immune response. Using data over 800 cervical and head & neck tumors The Cancer Genome Atlas (TCGA), we determined impact HPV status on mRNA expression all six MHC-I heavy chain genes, β2 microglobulin light chain....
The domestication process progressively differentiated wild relatives from modern cultivars, thus impacting plant-associated microorganisms. Endophytic bacterial communities play vital roles in plant growth, development, and health, which contribute to the crop's sustainable development. However, how impacts endophytic relevant root exudates wheat remains unclear. First, we have observed that increased microbial community diversity of while decreasing functional diversity. Second, decreased...
Several lines of evidence support an important role for Snail, a transcriptional factor, in breast cancer. Overexpression Snail has been associated with cancer metastasis, although the specific process remains unclear. To address this issue, expression levels RhoA and fibronectin, as well MMP‑2, were reduced tumor cell MDA‑MB‑231 MDA‑MB‑435S, their biological responses studied vitro vivo. For first time, it was observed that downregulated is correlated significant inhibition activity GTPase,...
High-risk human papillomaviruses (HPV) cause cancer at multiple distinct anatomical locations. Regardless of the tissue origin, most HPV positive (HPV+) cancers show highly upregulated expression p16 product cyclin-dependent kinase inhibitor 2A (CDKN2A) gene. Paradoxically, HPV+ tumor cells require continuous this suppressor for survival. Thus, restoration normal regulation has potential therapeutic value against induced cancers. Normally, transcription is tightly controlled epigenetic level...
Abstract Bone‐like apatite is a promising coating of poly(ether ether ketone) (PEEK) for bone implantation. Poly(aryl nitrile containing phthalazinone moiety (PPENK) novel alternative its easy synthesis. Here, chitosan/gelatin hybrid hydrogel applied to induce the formation on surface PPENK substrate through biomineralization improve biocompatibility and osteogenic property. possessing allyl groups (PPENK‐d) are synthesized spin‐coated impart reactive groups. The prepared by ultraviolet...
Abstract One obstacle for human solid tumor immunotherapy research is the lack of clinically relevant animal models. In this study, we sought to establish a chimeric antigen receptor (CAR) T-cell treatment model naturally occurring canine sarcomas as CAR therapy. Canine CARs specific B7-H3 were constructed using single-chain variable fragment derived from B7-H3–specific antibody MGA271, which confirmed be cross-reactive with B7-H3. After refining activation, transduction, and expansion...
Abstract Aiming at development of novel medical packings, poly (ethylene terephthalate) (PET)‐based membranes with hydrophobic and antibacterial properties were prepared by electrostatic spinning a blend thermoplastic polyurethane (TPU), nano SiO 2 Ag particles on PET nonwoven. In cooperation electro‐spun TPU/SiO layer, the water contact angle (WCA) nonwoven fabric was improved from 60° to 115–130°, vapour transmission rate 2200–2500 g/m /24 h. It indicates that modified membrane exhibits...