A5084388253- Advanced Photocatalysis Techniques
- Genetic Neurodegenerative Diseases
- Systemic Lupus Erythematosus Research
- TiO2 Photocatalysis and Solar Cells
- Gas Sensing Nanomaterials and Sensors
- Cerebrovascular and genetic disorders
- Glioma Diagnosis and Treatment
- Ammonia Synthesis and Nitrogen Reduction
- Liver Disease Diagnosis and Treatment
- Microbial Fuel Cells and Bioremediation
- Mitochondrial Function and Pathology
- Copper-based nanomaterials and applications
- Melanoma and MAPK Pathways
- Parkinson's Disease Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Pediatric Hepatobiliary Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Catalytic Processes in Materials Science
- Complement system in diseases
- Liver Diseases and Immunity
- Anesthesia and Pain Management
- Vasculitis and related conditions
- Neurological diseases and metabolism
- Cancer Mechanisms and Therapy
- Takotsubo Cardiomyopathy and Associated Phenomena
Niigata University
2015-2025
University of Fukui
2022-2024
University of Kelaniya
2022
University of Georgia
2022
Saitama University
2022
Mukogawa Women's University
2022
Savannah River National Laboratory
2022
Tohoku Medical and Pharmaceutical University Hospital
2018
Tokyo Metropolitan Ohtsuka Hospital
2016
National Hospital Organization
2016
We describe a strategy for developing hydrophilic chemical cocktails tissue delipidation, decoloring, refractive index (RI) matching, and decalcification, based on comprehensive profiling. More than 1,600 chemicals were screened by high-throughput evaluation system each process. The profiling revealed important factors: salt-free amine with high octanol/water partition-coefficient (logP) N-alkylimidazole aromatic amide RI protonation of phosphate ion decalcification. strategic integration...
The solar energy conversion efficiency considering the loss by external bias for water splitting reached ca. 0.9 or 1.35% using single- double-stacked photoanodes, respectively, of BiVO(4)/SnO(2)/WO(3) multilayers in a highly concentrated carbonate electrolyte aqueous solution.
We aimed to define the clinical features of liver dysfunction in patients with systemic lupus erythematosus (SLE).The frequency and causes were examined 206 SLE.Liver was evident 123 (59.7%) patients. Liver SLE can be drug-induced (30.9%) or caused by itself (28.5%), fatty (17.9%), autoimmune hepatitis (AIH) (4.9%), primary biliary cirrhosis (2.4%), cholangitis (1.6%), alcohol (1.6%) viral (0.8%), it tends mild except when AIH. Values for aminotransferase significantly increased AIH cause,...
Epithelioid glioblastoma is a rare aggressive variant of (GBM) characterized by dismal prognosis about 6 months and frequent leptomeningeal dissemination. A recent study has revealed that 50% epithelioid GBMs harbor three genetic alterations – BRAF V600E mutation, TERT promoter mutations, homozygous deletions CDKN2A/2B. Emerging evidence support the effectiveness targeted therapies for brain tumors with mutation. Here we describe dramatic radiographical response to combined therapy MEK...
Abstract Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on DNA theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, most abundant 3′−5′ exonuclease mammals. TREX1 cause adult-onset retinal vasculopathy with cerebral leukoencephalopathy (RVCL or RVCL-S). In RVCL, aberrant, C-terminally truncated mislocalizes nucleus due deletion its...
HTRA1-related cerebral small vessel disease (HRSVD) is a rare hereditary form of (CSVD) caused by HTRA1 pathogenic variants. Diagnosing HRSVD without genetic testing challenging because the lack distinctive imaging features and clinical symptoms, even family history can be unclear in some cases with HRSVD. This study investigates whether susceptibility-weighted (SWI) identify useful diagnostic findings for retrospective included 8 patients HRSVD, 12 autosomal dominant arteriopathy...
Activin A is a differentiation factor for β-cells and effective to promote β-cell neogenesis. also an autocrine activator of pancreatic stellate cells, which play critical role in fibrogenesis the pancreas. Conophylline (CnP) natural compound, reproduces effect activin on promotes neogenesis when administered vivo. However, its cells not known. We therefore investigated CnP both vitro Unlike A, inhibited activation cultured reduced production collagen. then analyzed involvement islet...
Aim To assess whether any form of osteopontin (OPN) is correlated with bone resorption markers or treatment effects in rheumatoid arthritis (RA). Method Subjects comprised 119 patients RA. RA disease activity was evaluated by Disease Activity Score (DAS) 28, erythrocyte sedimentation rate (ESR), and levels C-reactive protein (CRP), factor (RF) matrix metalloproteinase (MMP)-3. OPN plasma urine were measured enzyme-linked immunosorbent assay (ELISA). Levels tartrate-resistant acid phosphatase...
Abstract Primary spinal cord gliomas are rare and associated with high mortality. Unlike brain tumors, the clinicopathological features of not well defined. We analyzed clinical, histopathology, immunohistochemical overall survival (OS) 25 patients primary treated between 1994 2023 at 4 institutions. IDH1 R132H, H3K27M, p53 were assessed by immunohistochemistry (IHC). Four (16%), 5 (20%), 2 (8%), 13 (52%) diagnosed as having grades 1, 2, 3, according to World Health Organization (WHO) 2021...
Abstract Background & Aims Conophylline (CnP) is a vinca alkaloid purified from tropical plant and inhibits activation of pancreatic stellate cells. We investigated the effect CnP on hepatic cells ( HSC ) in vitro . also examined whether attenuates fibrosis vivo Method expression α‐smooth muscle actin (α‐ SMA collagen‐1, DNA synthesis apoptosis rat Lx‐2 induced by thioacetamide (TAA). Results In cells, reduced α‐ collagen‐1. inhibited serum. promoted caspase‐3 as assessed ladder...
In this study, we aimed to develop a dual-modal in vivo imaging based on over-1000 nm near-infrared (OTN-NIR) fluorescence and single photon emission computed tomography (SPECT)/computed (CT). As an OTN-NIR nanophosphor material, Ytterbium erbium ion co-doped yttrium phosphate nanoparticles (YPO4 NPs) was synthesized by hydrothermal synthesis method. Biocompatible poly(ethylene glycol) (PEG)/polycation block copolymer radioactive 111In were introduced the YPO4 NPs surface (PEG-111In-YPO4...
Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an autosomal-dominant disorder involving the cerebral, retinal, renal, and other systemic microvessels due to frameshift mutations in TREX1 gene. Under physiological conditions, protein localized cellular cytoplasm perinuclear area, but translocates into nucleus response oxidative DNA damage. It has been speculated that aberrant localization of may be associated microangiopathy patients RVCL. However, expression brain visceral...
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. autosomal recessive arteriopathy with subcortical infarcts leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss high-temperature requirement A1 (HTRA1) serine protease activity. In CARASIL, intimal thickening, smooth muscle cell (SMC) degeneration, elastic lamina splitting, vasodilation. The molecular mechanisms were proposed involve the accumulation matrisome proteins as...