A5070822882- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Robotic Path Planning Algorithms
- Maritime Navigation and Safety
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Advanced Image Processing Techniques
- Underwater Vehicles and Communication Systems
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
- Image and Signal Denoising Methods
- Viral Infections and Vectors
- RNA regulation and disease
- Circular RNAs in diseases
- Wireless Sensor Networks and IoT
- Gastric Cancer Management and Outcomes
- Animal Disease Management and Epidemiology
- Distributed Control Multi-Agent Systems
- SARS-CoV-2 detection and testing
- Image Processing Techniques and Applications
- Mosquito-borne diseases and control
- Advanced Vision and Imaging
- RNA modifications and cancer
Cleveland Clinic Florida
2020-2024
University of Chicago
2019-2024
Qilu Hospital of Shandong University
2021-2024
McGill University
2024
Samsung (China)
2024
Hong Kong Metropolitan University
2024
Institute of Information Engineering
2019-2023
Chinese Academy of Sciences
2019-2023
University of Chinese Academy of Sciences
2019-2023
Harbin Medical University
2019-2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme (ACE2). ACE2 is also the viral receptor SARS-CoV (SARS-CoV-1), a related that emerged in 2002–2003. Horseshoe bats (genus Rhinolophus ) are presumed to be original reservoir both viruses, and SARS-like coronavirus, RaTG13, closely SARS-CoV-2, has been identified one horseshoe-bat species. Here we characterize ability S-protein...
Retinoic acid-inducible gene I (RIG-I) is an important innate immune sensor that recognizes viral RNA in the cytoplasm. Its nonself recognition largely depends on unique structures imposed by RNA. The panhandle structure residing influenza A virus (IAV) genome, whose primary function to serve as promoter for transcription and replication, has been proposed be a RIG-I agonist. However, this never proved experimentally. Here, we employed multiple approaches determine if IAV directly involved...
The nucleus represents a cellular compartment where the discrimination of self from non-self nucleic acids is vital. While emerging evidence establishes nuclear DNA sensing paradigm, RNA, such as that nuclear-replicating RNA viruses, remains unexplored. Here, we report identification nuclear-resident RIG-I actively involved in viral sensing. RIG-I, along with its cytoplasmic counterpart, senses influenza A virus (IAV) replication leading to cooperative induction type I interferon response....
Abstract Molecular property prediction (MPP) is vital in drug discovery and reposition. Deep learning-based MPP models capture molecular property-related features from various molecule representations. In this paper, we propose a sequence embedding model facing with task. We pre-trained bi-directional encoder representations Transformers (BERT) to obtain the semantic representation of compound fingerprints, called Fingerprints-BERT (FP-BERT), self-supervised learning manner. Then, encoded by...
Multi-sensor fusion models play a crucial role in autonomous driving perception, particularly tasks like 3D object detection and HD map construction. These provide essential comprehensive static environmental information for systems. While camera-LiDAR methods have shown promising results by integrating data from both modalities, they often depend on complete sensor inputs. This reliance can lead to low robustness potential failures when sensors are corrupted or missing, raising significant...
ABSTRACT DDX3 belongs to the DEAD box RNA helicase family and is a multifunctional protein affecting life cycle of variety viruses. However, its role in influenza virus infection unknown. In this study, we explored potential discovered that an antiviral protein. Since many host proteins affect by interacting with certain components viral machinery, first verified whether has any interaction partners. Immunoprecipitation studies revealed NS1 NP as direct partners DDX3. Stress granules (SGs)...
ABSTRACT The inflammasome represents a molecular platform for innate immune regulation and controls proinflammatory cytokine production. NLRP3 is comprised of NLRP3, ASC, procaspase-1. When the activated, it causes ASC speck formation caspase-1 activation, resulting in maturation interleukin-1β (IL-1β). regulated at multiple levels, with one level being posttranslational modification. Interestingly, ubiquitination has been reported to be indispensable activation inflammasome. Influenza A...
The remote sensing image change detection methods based on deep learning have made great progress.However, many CNN-based persistently face challenges in connecting long-range semantic concepts because of their limited receptive fields. Recently, some that combine transformers effectively extract global information by modeling the context temporal and spatial domains has been proposed to solve problem, but they still suffer from both incorrect identification "non-semantic changes" incomplete...
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date. spike (S) protein, an unusually large number of mutations, considered the driver these phenotypes. We generated chimeric recombinant encoding S gene backbone ancestral isolate this virus naturally circulating variant. S-bearing robustly escapes vaccine-induced...
Abstract Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on DNA theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, most abundant 3′−5′ exonuclease mammals. TREX1 cause adult-onset retinal vasculopathy with cerebral leukoencephalopathy (RVCL or RVCL-S). In RVCL, aberrant, C-terminally truncated mislocalizes nucleus due deletion its...
Several families of enveloped viruses assemble and bud from the host cell plasma membranes (PM), including paramyxoviruses. Nipah virus (NiV) is a deadly zoonotic paramyxovirus causing yearly outbreaks in Southeast Asia with >75% mortality. NiV encodes matrix proteins (M) that drive assembly budding. NiV-M forms dimers interacts membrane lipids cell's PM for Using single-molecule localization microscopy single-particle tracking, we show F-actin maintains nanoscale organization sites at...
Elimination of infected cells by programmed cell death is a well-recognized host defense mechanism to control the spread infection. In addition apoptosis, necroptosis also one mechanisms that can be activated viral Activation leads phosphorylation mixed-lineage kinase domain-like protein (MLKL) receptor-interacting 3 (RIPK3) and results in MLKL oligomerization membrane translocation, leading disruption loss cellular ion homeostasis. It has recently been reported influenza A virus (IAV)...
ABSTRACT Activation of the RIG-I-like receptors, RIG-I and MDA5, establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15 whose mechanistic roles in innate immunity still remain enigmatic. Here we report that ISGylation essential for IFN responses mediated viral RNA sensor MDA5. conjugation to caspase activation recruitment domains MDA5 promotes formation higher-order assemblies thereby triggers against a range viruses including...
Herpes simplex virus 1 (HSV-1) infects several billion people worldwide and can cause life-threatening herpes encephalitis (HSE) in some patients. Monogenic defects components of the type I interferon system have been identified patients with HSE, emphasizing role inborn errors immunity underlying HSE pathogenesis. Here, we identify compound heterozygous loss-of-function mutations gene GTF3A encoding for transcription factor IIIA (TFIIIA), a component RNA polymerase III complex, patient...
Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, become important tools rational attenuation of viruses thereby vaccine design. Recent rapid progress has made establishment reverse functional analysis SARS-CoV-2, a coronavirus that causes ongoing COVID-19 pandemic resulted detrimental public health economic burden. Among different approaches, circular polymerase extension reaction (CPER) one leading methodologies to...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termini with poorly understood roles in regulating viral gene expression. Insulin and interferon-gamma, two host-derived, stress-related agents, virus spike protein, induce binding glutamyl-prolyl-tRNA synthetase (EPRS1), within an unconventional, tetra-aminoacyl-tRNA complex, to...