A5101923615- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac electrophysiology and arrhythmias
- Retinal Imaging and Analysis
- Cardiac Arrhythmias and Treatments
- Retinal Diseases and Treatments
- Renal Diseases and Glomerulopathies
- S100 Proteins and Annexins
- Magnesium in Health and Disease
- Chronic Kidney Disease and Diabetes
- Liver Disease and Transplantation
- Ocular Diseases and Behçet’s Syndrome
- Liver Disease Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Retinal and Optic Conditions
- Sleep and Wakefulness Research
- Sleep and related disorders
- Restless Legs Syndrome Research
- Genetic and Kidney Cyst Diseases
- Ion Transport and Channel Regulation
Shinrakuen Hospital
2018-2023
Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an autosomal-dominant disorder involving the cerebral, retinal, renal, and other systemic microvessels due to frameshift mutations in TREX1 gene. Under physiological conditions, protein localized cellular cytoplasm perinuclear area, but translocates into nucleus response oxidative DNA damage. It has been speculated that aberrant localization of may be associated microangiopathy patients RVCL. However, expression brain visceral...
Objective The progress of non-anticoagulated patients with atrial fibrillation (AF) undergoing hemodialysis has not been determined. Using data from the RAKUEN (Registry Atrial in chronic Kidney disease Under hEmodialysis Niigata) study, we examined clinical characteristics and outcomes among AF who were receiving a vitamin K antagonist (VKA).
【背景】透析患者において睡眠障害の訴えの頻度は高いものの，その実態については十分に解明されていない．【目的・方法】透析患者の睡眠評価のため，維持血液透析患者41名に自記式ピッツバーグ睡眠質問票（PSQI）による主観的評価とアクチグラフによる客観的評価を行った．【結果】PSQIでは，睡眠薬群では全例，睡眠薬なし群でも40％が睡眠障害ありと判定された．アクチグラフでは，入眠障害・中途覚醒の指標が不良で，総睡眠時間が短縮していた．睡眠薬なし群は，睡眠薬群より中途覚醒が多く，これは日中の覚醒困難の訴えと関連していた．【考察】健常人の報告例と比較し，主観では中途覚醒が頻回で，客観には入眠障害を示し中途覚醒も頻回であった．【結論】透析患者の睡眠は不良であり，睡眠薬の服用は中途覚醒に一部奏効しているが，入眠障害は残っている．睡眠薬なし群では入眠障害の訴えが表れにくく，日中覚醒困難を伴う中途覚醒とともに問題となる．