A5067667629- Seaweed-derived Bioactive Compounds
- Algal biology and biofuel production
- Oral and Maxillofacial Pathology
- Enzyme Production and Characterization
- Marine and coastal plant biology
- Lipid Membrane Structure and Behavior
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Biofuel production and bioconversion
- Steroid Chemistry and Biochemistry
- TGF-β signaling in diseases
- Bone Tissue Engineering Materials
- Protein Hydrolysis and Bioactive Peptides
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- DNA Repair Mechanisms
- Cleft Lip and Palate Research
- Advanced NMR Techniques and Applications
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Microbial Fuel Cells and Bioremediation
- Advanced Glycation End Products research
- Microbial Metabolites in Food Biotechnology
Mie University
2015-2025
Gifu University
2012-2021
Japan Science and Technology Agency
2008-2018
Seaweed Energy Solutions (Norway)
2018
Suita Municipal Hospital
2017
The University of Tokyo
2012
Health Sciences University of Hokkaido
1996-2011
National Center For Child Health and Development
2008
Action on Smoking and Health
2008
Ibaraki University
2006-2007
Abstract The inhibitory effect of brown algal phlorotannins on hyaluronidase was evaluated by an in vitro assay. Crude from the algae Eisenia bicyclis and Ecklonia kurome had a stronger than well-known inhibitors such as catechins sodium cromoglycate. IC50 values following six phlorotannins: phloroglucinol, unknown tetramer, eckol (a trimer), phlorofucofuroeckol A pentamer), dieckol 8,8′-bieckol (hexamers), were 280, 650, >800, 140, 120 40 μm, respectively. catechin, epigallocatechin...
Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types are not easily accessible minimally invasive procedures. Here we evaluated dental pulp (DPCs) as an optimal source iPS cells, since they obtained from extracted teeth and be expanded under simple culture conditions. From all 6 DPC lines tested with the conventional 3 or 4 reprogramming factors, were effectively established 5 lines. Furthermore, determination...
In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. this present study, we characterized hDPSCs an earlier developmental stage to evaluate the potential usage of these for tissue-regenerative therapy. at crown-completed showed a higher proliferation rate than those later stage. When either group cultured in medium promoting differentiation toward osteo/odontoblastic lineage, both became alkaline-phosphatase-positive, produced calcified matrix, and...
The G -->T transversion mutation, ade6-M26, creates the heptanucleotide sequence ATGACTG, which lies close to 5' end of open reading frame ade6 gene in Schizosaccharomyces pombe. mutation generates a meiosis-specific recombination hot spot and binding site for Mts1/Mts2 protein. We examined chromatin structure at locus M26 strain compared it that wild-type spot-negative control M375. Micrococcal nuclease (MNase) digestion indirect end-labeling methods were applied. In strain, we detected...
Oral squamous cell carcinoma and the most common oral pre-malignancies appear to be related habit of betel-quid chewing in Sri Lanka. Although hypermethylation tumour suppressor genes cancer have been well documented, little information has available concerning pre-cancerous lesions. In present study, we investigated p14, p15 p16 lesions including epithelial dysplasia submucous fibrosis.All samples were obtained from patients with a Sixty-four clinically diagnosed leukoplakia,...
Exosomes are small vesicles secreted from many cell types. Their biological effects largely depend on their cellular origin and the physiological state of originating cells. by mesenchymal stem cells exert therapeutic against multiple diseases may serve as potential alternatives to therapies. We previously established characterized human leukocyte antigen (HLA) haplotype homo (HHH) dental pulp (DPC) lines wisdom teeth. In this study, we aimed investigate effect local administration HHH-DPC...
The crude phlorotannins from the brown alga Eisenia bicyclis showed inhibitory activity against 10 of 13 kinds glycosidases present in viscera turban shell Turbo cornutus. Phloroglucinol and its oligomers – eckol (a trimer), phlorofucofuroeckol A pentamer), dieckol 8,8′-bieckol (hexamers), an unidentified tetramer were isolated by column thin-layer chromatography. Phlorofucofuroeckol A, inhibited α-fucosidase, β-galactosidase β-mannosidase partially purified T. cornutus, while...
The purpose of this study was to determine whether bone augmentation could be obtained by the composite recombinant human morphogenetic protein-2 (rhBMP-2) and bioabsorbable atelocollagen when periosteum resected, compare efficacy rhBMP-2/collagen implant collagen alone implant. onlay inserted into space between elevated galea aponeurotica skull without 10-month-old rats. resulted in osteoblasts differentiation under at 1 week active formation a prior cartilage. At 4 weeks, bony trabeculae...
Meiotic recombination is initiated by DNA double-stranded break (DSB) formation catalyzed Spo11, a type-II topoisomerase-like transesterificase, presumably via dimerization-mediated mechanism. We demonstrate the existence of in vivo interactions between Spo11 proteins carrying distinct tags, and chromatin-binding DSB activity tagged at innate targeted sites upon fusion to Gal4 DNA-binding domain. First we identified interaction Spo11-3FLAG Gal4BD-Spo11 proteins, established that this...