A5102880716- Meningioma and schwannoma management
- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Optical Imaging and Spectroscopy Techniques
- Head and Neck Surgical Oncology
- Transcranial Magnetic Stimulation Studies
- Pharmacological Effects and Toxicity Studies
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Ophthalmology and Eye Disorders
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Thermoregulation and physiological responses
Nishi Niigata Chuo National Hospital
2000-2025
National Hospital Organization
2019-2023
Kitano Hospital
2019
Children's Hospital of Michigan
2019
Yokohama City University
2019
Kanagawa Children's Medical Center
2019
Wayne State University
2019
Detroit Medical Center
2019
City University of Seattle
2019
Showa University
2019
ABSTRACT In order to clarify the distribution of bifidobacterial species in human intestinal tract, a 16S rRNA-gene-targeted species-specific PCR technique was developed and used with DNAs extracted from fecal samples obtained 48 healthy adults 27 breast-fed infants. To cover all that have been isolated identified primers for Bifidobacterium longum , B. infantis dentium gallicum were adolescentis angulatum bifidum breve catenulatum group ( pseudocatenulatum ) previous study (T. Matsuki, K....
In this paper, the authors' goal was to report their novel presurgical simulation method applying interactive virtual (IVS) using 3D computer graphics (CG) data and microscopic observation of color-printed plaster models based on these CG in surgery for skull base deep tumors.For 25 operations 23 patients with or intracranial tumors (meningiomas, schwannomas, epidermoid tumors, chordomas, others), authors carried out created by image analysis radiological data. Interactive performed...
We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest during a motor task to study the mechanism of improvement induced by deep brain stimulation internal globus pallidus in Parkinson's disease. Six right-handed patients disease were scanned while performing predictable paced sequence reaching movements observing same screen displays tones. PET studies performed ON OFF medication-free state. Internal improved off-state United Disease...
<h3>Objective:</h3> To determine whether monitoring facial nerve motor-evoked potentials (FNMEPs) elicited by transcranial electrical stimulation during skull base tumour surgery is useful for predicting outcome. <h3>Methods:</h3> This study analysed FNMEP findings in 26 patients with tumours. Corkscrew electrodes positioned at C3 or C4 and Cz were used to deliver supramaximal stimuli (180–550 V). FNMEPs recorded from the orbicularis oculi oris muscles. The correlation between...
<b><i>Background:</i></b> Dopaminergic therapy with levodopa improves motor function in PD patients, but the effects of on cognition remain uncertain. <b><i>Objective:</i></b> To use H<sub>2</sub><sup>15</sup>O and PET to assess effect infusion sequence learning PD. <b><i>Methods:</i></b> Seven right-handed patients were scanned "on" "off" while performing a task. The changes performance regional brain activation that occurred during this intervention assessed. <b><i>Results:</i></b> During...
Abstract We studied 6 advanced‐stage Parkinson's disease patients with [ 18 F] fluorodeoxyglucose/positron emission tomography before and 3 months after unilateral ablation of the subthalamic nucleus performed microelectrode mapping. Operative changes in glucose metabolism were assessed by comparing baseline postoperative scans. also quantified operative activity an abnormal disease‐related metabolic network that we had identified previous studies. Following ablation, a highly significant...
Abstract In a previous H 2 15 O/PET study of motor sequence learning, we used principal components analysis (PCA) region interest (ROI) data to identify performance‐related activation patterns in normal subjects and patients with Parkinson's disease (PD). the present study, determined whether these predicted learning performance subsequent untreated PD cohorts. Using voxel‐based PCA approach, correlated changes network activity that occurred during antiparkinsonian treatment their...
The authors retrospectively analyzed various clinicopathological factors to determine which are related regrowth during a long-term follow-up period in patients who underwent incomplete vestibular schwannoma (VS) resection.This study involved 74 (25 men and 49 women) whom VS was treated surgically via the lateral suboccipital approach, had postoperative periods exceeding 5 years. mean 104.1 months (range 60-241 months), patient age at surgery 48.1 years 19-75 years). tumors ranged size from...
BACKGROUND: Despite recent diagnostic and technical advancements in the field of neurosurgery, surgical treatment for tumors skull base region, ie, (SBTs), remains a challenge. OBJECTIVE: To validate utility presurgical simulation SBTs by 3-dimensional multifusion volumetric imaging (3D MFVI), including volume rendering image fusion, to combine data from various modalities. METHODS: We performed using 3D MFVI 21 (acoustic neurinomas, jugular meningiomas, chordomas, others) 20 patients....
Radiation monotherapy-prophylactic craniospinal or whole-brain irradiation paired with a radiation boost to the primary tumor-is standard treatment for intracranial germinomas at authors' institution. The authors assessed long-term outcomes of patients germinoma who underwent therapy and identified factors affecting them.The retrospectively analyzed data obtained in 46 (35 males 11 females, age 5-43 years diagnosis) had been treated between 1990 2009 Thirty localized regions 16 multiple...
Mesial temporal lobe epilepsy (MTLE) is the most frequent focal epileptic syndrome in adults, and majority of seizures originate primarily from hippocampus. The resected hippocampal tissue often shows severe neuronal loss, a condition referred to as sclerosis (HS). In order understand epileptogenesis MTLE, it seems important clarify any discrepancies between clinical pathological features affected patients. Here we investigated epileptiform activities ex vivo using living taken patients with...
RLF (relaxin-like factor), also known as INSL3 (insulin-like peptide 3), is a novel member of the relaxin/insulin gene family that expressed in testicular Leydig cells. Despite implicated role RLF/INSL3 testis development, its native conformation remains unknown. In present paper we demonstrate for first time boar isolated monomeric structure with full biological activity. Using series chromatography steps, was highly purified single peak reverse-phase HPLC. MS/MS (tandem MS) analysis...
The purpose of this paper is to report on the authors' advanced presurgical interactive virtual simulation technique using a 3D computer graphics model for microvascular decompression (MVD) surgery.The authors performed prior surgery in 26 patients with trigeminal neuralgia or hemifacial spasm. models were composed brainstem, cerebellum, cranial nerves, vessels, and skull individually created by image analysis, including segmentation, surface rendering, data fusion collected 3-T MRI 64-row...
Intensive genetic analysis was performed to reveal comprehensive molecular insights into hypothalamic hamartoma (HH).Thirty-eight individuals with HH were investigated by whole exome sequencing, target capture-based deep or single nucleotide polymorphism (SNP) array using DNA extracted from blood leukocytes samples.We identified a germline variant of KIAA0556, which encodes ciliary protein, and 2 somatic variants PTPN11, forms part the RAS/mitogen-activated protein kinase (MAPK) pathway, as...
Abstract In patients with hemifacial spasm (HFS), a lateral spread response (or abnormal muscle response) is recorded from facial muscles after nerve stimulation. The origin of this not completely understood. We studied the responses elicited by double stimulation in 12 HFS during microvascular decompression. was mentalis electrical temporal branch or orbicularis oculi marginal mandibular branch. interstimulus intervals (ISIs) ranged 0.5 to 7.0 ms. R1 defined as first stimulus, and R2 second...
Abstract We used 15 O ‐labeled water and positron emission tomography to assess the effect of deep brain stimulation internal globus pallidus on motor sequence learning in Parkinson's disease. Seven right‐handed patients were scanned off while they performing a task kinematically matched execution reference task. The scans performed after 12‐hour medication washout. Stimulation parameters adjusted for maximal improvement; experimental held constant across conditions. Internal improved...
OBJECTIVE We retrospectively analyzed various clinical factors to determine whether or not these are etiopathologically related the development of hydrocephalus in patients with vestibular schwannomas. METHODS There were 68 (29 men, 39 women) this study who underwent resection a schwannoma. The age at time surgery ranged from 19 76 years (mean age, 51.4 yr). maximum diameter tumor cerebellopontine cistern 0 (localized within internal auditory canal) 56 mm (mean, 32.0 ± 12.9 mm)....