A5038056228- Glioma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Histone Deacetylase Inhibitors Research
- Congenital Diaphragmatic Hernia Studies
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- ATP Synthase and ATPases Research
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Amino Acid Enzymes and Metabolism
- Connexins and lens biology
- Single-cell and spatial transcriptomics
- Nuclear Receptors and Signaling
- Renal and related cancers
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Renal cell carcinoma treatment
Yokohama City University
2004-2023
Yokohama City University Hospital
2014-2023
Kumamoto University
2004-2014
GTx (United States)
1997
ABSTRACT To clarify the mechanisms that regulate neuroendocrine differentiation of fetal lung epithelia, we have studied expression mammalian homologs achaete-scute complex (Mash1) (Ascl1 – Mouse Genome Informatics); hairy and enhancer split1 (Hes1); Notch/Notch-ligand system in adult mouse lungs, lungs Mash1- or Hes1-deficient mice. Immunohistochemical studies revealed Mash1-positive cells seemed to belong pulmonary (PNEC) their precursors. In mice deficient for Mash1, no PNEC were...
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Abstract Neocortical γ‐aminobutyric acid (GABA)ergic neurons have been previously described as largely involved in local intracortical circuitry. However, our recent findings the murine model select neocortical GABAergic that project to both neighboring and more distant regions. Here, we investigated whether such projection are also found cat neocortex. Wheat germ agglutinin‐conjugated horseradish peroxidase (WGA‐HRP) was injected into visual, auditory, or somatosensory cortex, order label...
Oligodendroglioma has a relatively favorable prognosis, however, often undergoes malignant progression. We hypothesized that preclinical models of oligodendroglioma could facilitate identification therapeutic targets in progressive oligodendroglioma. established multiple xenografts to determine if the PI3K/AKT/mTOR signaling pathway drives tumor progression.Two anatomically distinct samples from patient who developed anaplastic (AOD) were collected for orthotopic transplantation mice....
Primary central nervous system lymphoma (PCNSL) is an isolated type of the and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations MYD88 CD79B in immunocompetent PCNSL, whereas LMP1 activation commonly observed Epstein-Barr virus (EBV)-positive PCNSL. However, lack clinically representative preclinical models hampered our understanding pathogenic mechanisms by which genetic aberrations drive PCNSL disease phenotypes. Here,...
Abstract We present a case of 14-year old boy with tumor-associated refractory epilepsy. Positron emission tomography imaging demonstrated region heterogeneous high 11 C-methionine uptake and homogenous low 18 F-fluorodeoxyglucose within the tumor. Histopathological genomic analyses confirmed tumor as BRAF V600E-mutated polymorphous low-grade neuroepithelial young (PLNTY). Within high-methionine-uptake region, we observed increased protein levels L-type amino acid transporter 1 (LAT1), major...
Abstract Purpose: The 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors uses an integrated approach involving histopathology and molecular profiling. Because majority adult malignant brain are gliomas primary CNS lymphomas (PCNSL), rapid differentiation these diseases is required for therapeutic decisions. In addition, diffuse require information on single-nucleotide variants (SNV), such as IDH1/2. Here, we report intraoperative diagnostic (i-ID) to...
To evaluate the effects of nerve-muscle pedicle (NMP) method on rat thyroarytenoid (TA) muscle after transection recurrent laryngeal nerve (RLN).Quantitative histologic assessment TA NMP implantation.Thirty-six Wistar rats were divided into two groups: animals subjected to left RLN alone (DNV group) and followed by immediate transplantation a flap containing sternohyoid (SH) ansa cervicalis branch (NMP group). Animals killed 2, 4, 10 weeks treatments. The stained with hematoxylin-eosin was...
Succinate dehydrogenase-deficient renal cell carcinoma (SDH-deficient RCC) is a newly introduced histological type of RCC, which caused by loss subunit genes SDH. It known to frequently demonstrate familial occurrence and be associated with gastrointestinal stromal tumors paraganglioma. To date, only 53 cases have been reported. Here, we present an additional case SDH-deficient RCC occurring in 40-year-old female. The tumor was histologically biphasic, consisting tubular solid architectures....
In the revised World Health Organization classification 2016, anaplastic pleomorphic xanthoastrocytoma ( PXA ) has been newly defined as a variant of entity. Furthermore, some were reported to have extremely poor prognosis which showed type pediatric glioblastoma GBM molecular profile. Recent integrated for primary central nervous system tumors proposed differences between histological and features. Herein, in genome‐wide analysis, we show an extreme aggressive that resulted A full...
Endometrial stromal tumors (ESTs) are composed of cells resembling endometrial stroma, and divided into benign malignant types based on morphology. nodule (ESN) is a localized tumor, sarcoma (ESS) an infiltrative potentially metastatic neoplasm. A series genetic aberrations contribute to pathological diagnosis ESTs. At present, subsets ESN ESS-low grade (ESS-LG) characterized as JAZF1-SUZ12/JJAZ1 gene fusion. The ESTs that show higher atypia but lack nuclear pleomorphism include YWHAE-FAM22...