A5085420639- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Glioma Diagnosis and Treatment
- Peripheral Artery Disease Management
- Gout, Hyperuricemia, Uric Acid
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Heart Rate Variability and Autonomic Control
- Coronary Artery Anomalies
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal and Vascular Pathologies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aortic Thrombus and Embolism
- Cardiovascular Disease and Adiposity
Shonan Kamakura General Hospital
2018-2024
University Health Network
2024
Toronto General Hospital
2024
Yokohama City University
2002-2024
Yokohama City University Hospital
2021-2024
Osaka University
2024
Okayama University Hospital
2024
Hayashi Eye Hospital
1982-2023
Tokyo Women's Medical University
1998-2023
Hokkaido University Hospital
2023
To compare the occurrence of cerebral, cardiovascular, and renal events in patients with hyperuricaemia treated febuxostat those conventional therapy lifestyle modification.This multicentre, prospective, randomized open-label, blinded endpoint study was done 141 hospitals Japan. A total 1070 were included intention-to-treat population. Elderly (serum uric acid >7.0 to ≤9.0 mg/dL) at risk for or disease, defined by presence hypertension, Type 2 diabetes, history cerebral cardiovascular...
Abstract Purpose: Molecular targeted therapy using BRAF and/or MEK inhibitors has been applied to BRAFV600E-mutant high-grade gliomas (HGG); however, the therapeutic effect is limited by emergence of drug resistance. Experimental Design: We established multiple paired HGG patient-derived xenograft models based on tissues collected prior and at relapse after molecular therapy. Using these models, we dissected treatment-resistant mechanisms for explored targets overcome resistance in BRAFV600E...
Worldwide, colorectal cancer is the third most common type of affecting both sexes. It has been proposed that a small subset cells (cancer stem cells) within each tumor able to initiate growth. In 2007, two research groups simultaneously identified colon cell population in human tumors by use CD133 expression. present study, we used line, SW620, analyze cell-like characteristics + vitro and vivo. vitro, SW620 had higher proliferative capacity, were more irradiation- chemotherapy-resistant,...
Production and regulation of activin A inhibin B during the cycle seminiferous epithelium were investigated in adult rats. Immunohistochemistry localised β -subunit to Sertoli cell cytoplasm, with much weaker expression spermatocytes spermatids. Both B, measured by ELISA secreted by, tubule fragments over 72 h culture. Activin was a cyclic manner peak secretion from tubules isolated at stage VIII. Tubules collected VI produced least A. Inhibin highest IX-I lowest VII tubules. Addition...
Human mesenchymal stem cells (hMSCs) are multipotent found in the adult bone marrow that have capacity to differentiate into various cell types. The hMSCs may provide a potential therapy restore damaged tissues or organs of origin; however, drawback is their limited life span vitro.We immortalized normal with retrovirally transmitted human telomerase reverse transcriptase cDNA. One clones (YKNK-12) was established, and biological characteristics were investigated vitro vivo.YKNK-12 capable...
It has been proposed in human colorectal cancers (CRC) a minority subset of cancer cells within tumors able to initiate tumor growth, defined as stem (CSC). Solid primary colonic and its ovarian metastatic tissues were collected from fresh surgical samples subsequent xenografts established nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. The resulting disaggregated into single-cell suspensions CD133(-) cell line (NANK) was newly analyzed by flow cytometry. Surface markers...
Induced pluripotent stem (iPS) cells are a type of undifferentiated cell that can be obtained from differentiated and have the potential to differentiate into musculoskeletal system, myocardium, vascular endothelial cells, neurons, hepatocytes. We therefore cultured mouse iPS in DMEM containing 15% FBS, 10 −7 M dexamethasone, mM β-glycerophosphate, 50 μg/ml ascorbic acid for 3 weeks, order induce bone differentiation, studied expression differentiation markers Runx2 osteocalcin using RT-PCR...
Aquaporin (AQP) is a molecule that facilitates water permeability through cell membranes and widely distributed in the mammalian body. Among members of AQP family, AQP7 AQP8 are predominantly expressed testis. This paper examined expression these two AQPs developing rat testis, using northern blot immunohistochemistry to visualize their roles during progression spermatogenesis In adult rats, was localized spermatids, whereas protein observed spermatocytes. transcripts became detectable...
This study investigated the relationship between timing of ventricular tachycardia or fibrillation (VT VF) and prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).It is unknown whether VT/VF occurrence affects with AMI.From January 2004 to December 2014, 1004 AMI underwent PCI. Of these patients, 888 did not have (non-VT/VF group) 116 had sustained during prehospitalization hospitalization. Patients were divided into two...
Abstract We present a case of 14-year old boy with tumor-associated refractory epilepsy. Positron emission tomography imaging demonstrated region heterogeneous high 11 C-methionine uptake and homogenous low 18 F-fluorodeoxyglucose within the tumor. Histopathological genomic analyses confirmed tumor as BRAF V600E-mutated polymorphous low-grade neuroepithelial young (PLNTY). Within high-methionine-uptake region, we observed increased protein levels L-type amino acid transporter 1 (LAT1), major...
To evaluate the short-, long-term clinical and angiographic outcomes after treatment of true bifurcation lesions using a modified jailed balloon technique (MJBT).Percutaneous coronary intervention (PCI) for has high risk adverse events. Side branch (SB) occlusion is one most serious complications. Therefore, novel strategies to avoid SB during main stenting keep its patency are important.Between February 2015 2018, 328 patients with 349 underwent PCI MJBT. True were defined as Medina...
Abstract Objectives Hyperuricaemia is recognized as an independent risk marker for cardiovascular and renal diseases. However, uric acid a powerful free-radical scavenger, the optimal level of serum (SUA) determining outcomes unknown. This study explored whether interventional treatments excessive SUA reduction were harmful what constituted lowering levels prevention events in patients with asymptomatic hyperuricaemia. Methods was post hoc analysis randomized trial (Febuxostat Cerebral...