A5090938829- Gout, Hyperuricemia, Uric Acid
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Atrial Fibrillation Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Case Reports on Hematomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Alcohol Consumption and Health Effects
- Nuclear Structure and Function
- Enzyme Structure and Function
- Cellular transport and secretion
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Renal Diseases and Glomerulopathies
- Antiplatelet Therapy and Cardiovascular Diseases
- Potassium and Related Disorders
- Genetic and Kidney Cyst Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Tokyo Metropolitan University
2012-2023
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Kindai University
2014
Nagoya University
2007-2014
University of Miyazaki
1990-2012
Medical University of Silesia
2012
Poznan University of Medical Sciences
2012
Alexandria University
2012
Far Eastern Memorial Hospital
2012
To compare the occurrence of cerebral, cardiovascular, and renal events in patients with hyperuricaemia treated febuxostat those conventional therapy lifestyle modification.This multicentre, prospective, randomized open-label, blinded endpoint study was done 141 hospitals Japan. A total 1070 were included intention-to-treat population. Elderly (serum uric acid >7.0 to ≤9.0 mg/dL) at risk for or disease, defined by presence hypertension, Type 2 diabetes, history cerebral cardiovascular...
Background: Evidence regarding the primary prevention of coronary artery disease events by low-density lipoprotein cholesterol (LDL-C) lowering therapy in older individuals, aged ≥75 years, is insufficient. This trial tested whether LDL-C–lowering with ezetimibe useful for cardiovascular patients. Methods: multicenter, prospective, randomized, open-label, blinded end-point evaluation conducted at 363 medical institutions Japan examined preventive efficacy patients elevated LDL-C without...
The cerebellar inositol 1,4,5-trisphosphate (InsP3) receptor is a high molecular weight glycoprotein abundantly expressed in Purkinje cells.The subunit structure of the InsP3 protein was examined by cross-linking experiments.Agarose-polyacrylamide gel electrophoresis cross-linked materials demonstrated that InsPs composed four noncovalently bound identical subunits each with M, 320,000 both purified and microsome-bound states.Chromatography on calmodulin-Sepharose column Ca2+-dependent...
To examine the effects of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, advanced glycation end product (AGE)-receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes patients.Sixty-one patients whose HbAlc ≥ 6.1% (mean age 64.7 years; 67% men; mean 7.4%; 57% were pharmacologically treated) underwent blood urine sampling analysis before after 12 weeks treatment with alogliptin (25 mg once daily).Alogliptin significantly reduced fasting (160.3 mg/dL at...
We examined the relationship between cardiac hypertrophy, myosin heavy chain (MHC) isoform expression, and production of atrial natriuretic factor (ANF) brain peptide (BNP) before after development DOCA-salt hypertension. rats exhibited significant left ventricular hypertrophy at prehypertensive stage (1 week treatment), without MHC switch or change in gene expression. In hypertensive (5 weeks pronounced was observed, this characterized by an increase β-MHC protein, resulting a from 90%...
The mechanism underlying the mineralocorticoid escape phenomenon remains unknown. To assess possible contribution of natriuretic peptides to escape, rats were injected with 5 mg deoxycorticosterone acetate for 3 d. Plasma atrial factor (ANF) rose twice basal levels and ANF content decreased significantly by 24 h treatment. This coincided renal a significant increase in urinary cGMP excretion. remained elevated continued decline 48 72 while mRNA increased only at h. brain peptide did not...
Small, regulatory, non-coding RNA (ncRNA) is involved in various cell functions both prokaryotes and eukaryotes. However, information on ncRNA cyanobacteria still scarce. We studied genes by computational screening to compare the intergenic regions of Synechococcus elongatus PCC 6301 genome with genomes three freshwater cyanobacteria. identified an gene S. elongatus, which has been previously described as yfr1 marine The 65 nucleotides long positioned between guaB trxA. found a high...
Uroguanylin, a new natriuretic peptide originally isolated from urine, stimulates the membrane guanylate cyclase C receptor. No information, however, is available on plasma and urine levels of uroguanylin in nephrotic syndrome (NS), state associated with sodium water retention. Using sensitive radioimmunoassay, we measured concentrations immunoreactive (ir-)uroguanylin NS patients compared them those non-nephrotic glomerulonephritis. Plasma ir-uroguanylin, blood pressure cardiothoracic ratio...
BAG6 (also called Scythe) interacts with the exposed hydrophobic regions of newly synthesized proteins and escorts them to degradation machinery through mechanisms that remain be elucidated. In this study, we provide evidence physically model defective protein substrate CL1 in a manner depends directly on its short hydrophobicity. We found N terminus contains an evolutionarily conserved island tentatively designated ubiquitin-linked domain. Partial deletion domain N-terminal fragment...
A recent meta‐analysis found no benefit of uric acid‐lowering therapy including febuxostat on death, cardiovascular events, or renal impairment. However, there may be populations that from in reducing mortality and cerebral events. The aim the present study was to examine clinical elderly patients stratified by age using Febuxostat for Cerebral CaRdiorenovascular Events PrEvEntion StuDy (FREED) data. FREED a randomized involving aged 65 years older with hyperuricemia risk factors cerebral,...
This study assesses whether presence of cognitive dysfunction can be a marker associated with the development cardiovascular disease (CVD) events independent ambulatory blood pressure (BP) or other indices target organ damage (TOD) in elderly hypertensive patients.We recruited 585 patients (mean age, 73 years; 41% men) who were ambulatory, lived independently, and without clinically overt dementia. Cognitive function was assessed by Mini-Mental State Examination (MMSE) at baseline, CVD...
ZFP36L2 promotes the destruction of AU-rich element-containing transcripts, while its regulation and functional significance in cell cycle control are scarcely identified. We show that is a cycle-regulated CCCH protein whose abundance regulated post-translationally at respective stages cycle. Indeed, was eliminated after release from M phase, ZYG11B-based E3 ligase plays role polyubiquitination interphase. Although dispensable for normal progression, we found endogenous played key...
Effects of dietary n-3 polyunsaturated fatty acids (n–3 PUFA) intake on the cardiovascular system have been reported, and thus we hypothesized that prevalence hypertensive remodeling would be lower in a fishing than farming community We recruited 263 essential hypertensives from 333 village; all subjects were ≥40 years (mean 73 years;42% men). They cross-sectionally examined for serum eicosapentaenoic acid (EPA ) docosahexaenoic (DHA), asymmetric dimethylarginine (ADMA) levels, left...
✓ A brown tumor is a secondary disorder of bone associated with hyperparathyroidism that arises predominantly in the metacarpals, phalanges, jaw, pelvis, or femur. Rarely does this involve spine. The authors describe case primary hyperparathyroidism, causing spinal cord compression. first step diagnosing lesion an unusual site high index suspicion. Essentially, benign but emergency surgery for removal recommended patients showing acute
Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention patients with newly diagnosed non-valvular AF (NAVF) that being conducted 35 countries.
Abstract Objectives Hyperuricaemia is recognized as an independent risk marker for cardiovascular and renal diseases. However, uric acid a powerful free-radical scavenger, the optimal level of serum (SUA) determining outcomes unknown. This study explored whether interventional treatments excessive SUA reduction were harmful what constituted lowering levels prevention events in patients with asymptomatic hyperuricaemia. Methods was post hoc analysis randomized trial (Febuxostat Cerebral...