A5068942470- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Orthopaedic implants and arthroplasty
- RNA Interference and Gene Delivery
- Superconducting Materials and Applications
- Cardiovascular Function and Risk Factors
- biodegradable polymer synthesis and properties
- Cellular Mechanics and Interactions
- Bone health and osteoporosis research
- Tracheal and airway disorders
- Radiation Detection and Scintillator Technologies
- Photovoltaic System Optimization Techniques
- Atrial Fibrillation Management and Outcomes
- Liver physiology and pathology
- Coronary Interventions and Diagnostics
- Atomic and Subatomic Physics Research
- Angiogenesis and VEGF in Cancer
- solar cell performance optimization
- Physics of Superconductivity and Magnetism
Tohoku University
1974-2025
University of Toyama
2025
National Center for Global Health and Medicine
2011-2024
Center for Global Health
2011-2024
Health Sciences University of Hokkaido
2009-2024
Osaka University
2005-2024
Aichi University of Technology
2020-2023
Kyoto University
2010-2021
RELX Group (United States)
2020
Osaka Red Cross Hospital
2020
A defect in Klotho gene expression mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression extends life span. protein functions as a circulating hormone binds to cell-surface receptor and represses intracellular signals insulin insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending Alleviation aging-like phenotypes Klotho-deficient was observed by perturbing IGF1 signaling, suggesting Klotho-mediated inhibition...
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit variety of aging-like phenotypes, many which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that and FGF23 may function common signal transduction pathway(s), we investigated whether is involved FGF signaling. Here show protein directly binds multiple receptors (FGFRs). Klotho-FGFR complex with higher affinity than FGFR or...
klotho is an aging suppressor gene and extends life span when overexpressed in mice. Klotho protein was recently demonstrated to function as a hormone that inhibits insulin/insulin-like growth factor-1 (IGF-1) signaling. Here we show increases resistance oxidative stress at the cellular organismal level mammals. activates FoxO forkhead transcription factors are negatively regulated by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide dismutase. This turn...
Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine that stimulates glucose uptake in adipocytes. Here, we show FGF21 activity depends on betaKlotho, single-pass transmembrane protein whose expression induced during differentiation from preadipocytes to BetaKlotho physically interacts with FGF receptors 1c and 4, thereby increasing the ability of these bind activate MAP kinase cascade. Knockdown betaKlotho by siRNA adipocytes diminishes FGF21. Importantly, administration into...
Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, vitamin D homeostasis. These FGFs require the presence of Klotho/betaKlotho their target tissues. Here, we present crystal structures FGF19 alone FGF23 complex with sucrose octasulfate, a disaccharide chemically related heparin. The conformation heparin-binding region between beta strands 10 12 diverges completely from common adopted by...
Abstract To develop a carrier for the controlled release of biologically-active growth factors, biodegradable hydrogels were prepared through glutaraldehyde cross-linking gelatin with isoelectric points (IEP) 5.0 and 9.0, i.e. 'acidic' 'basic' gelatins, respectively. Radioiodinated factors used to investigate their sorption desorption from hydrogel both types gelatin. Basic fibroblast factor (bFGF) transforming factor-β1 (TGF-β1) well sorbed time acidic hydrogel, while less was observed...
Background: Evidence regarding the primary prevention of coronary artery disease events by low-density lipoprotein cholesterol (LDL-C) lowering therapy in older individuals, aged ≥75 years, is insufficient. This trial tested whether LDL-C–lowering with ezetimibe useful for cardiovascular patients. Methods: multicenter, prospective, randomized, open-label, blinded end-point evaluation conducted at 363 medical institutions Japan examined preventive efficacy patients elevated LDL-C without...
An analytical processing design is proposed to accumulate nano-plastics diluted in water-based solvents and evaluate their individual IR spectral properties.
Using integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT), the clinical significance of 18F-FDG uptake was evaluated in patients with primary breast cancer. Clinicopathological correlation level maximum standardized values (SUV) 60 min obtained from preoperative PET/CT were examined 152 The prognostic impact SUV explored using simulated prognosis derived computed program Adjuvant! 136 (89%) invasive ductal carcinoma (IDC). High...
Proper wound diagnosis and management is an increasingly important clinical challenge a large growing unmet need. Pressure ulcers, hard-to-heal wounds, problematic surgical incisions are emerging at increasing frequencies. At present, the wound-healing industry experiencing paradigm shift towards innovative treatments that exploit nanotechnology, biomaterials, biologics. Our study utilized alginate hydrogel patch to deliver stromal cell-derived factor-1 (SDF-1), naturally occurring chemokine...
Abstract The aim of the present study was to assess bone regeneration process in defects introduced into rabbit long bones, which were regenerated with controlled release recombinant morphogenetic protein-2 (rBMP-2). orientation biological apatite (BAp) c-axis and mineral density (BMD) compared as predictors mechanical function. A 20-mm-long defect ulnas, 17 µg rBMP-2 controlled-released using a biodegradable gelatin hydrogel carrier. In process, two characteristic phases may have been...
Recent findings have suggested that the autophagic isolation membrane (IM) might originate from a domain of endoplasmic reticulum (ER) called omegasome. However, morphological relationships between ER, omegasome, and IM remain unclear. In present study, we found hybrid structures composed double FYVE domain-containing protein 1 (DFCP1)-positive omegasome accumulated in Atg3-deficient mouse embryonic fibroblasts (MEFs). Moreover, correlative light electron microscopy immunoelectron revealed...
Late lumen enlargement (LLE) - a positive remodelling phenomenon after drug-coated balloon (DCB) angioplasty for stable coronary disease contributes to lower restenosis rate. However, lesion characteristics promoting LLE remain unclear.
Background Limb ischemia remains a challenge. To overcome shortcomings or limitations of gene therapy cell transplantation, sustained release system basic fibroblast growth factor (bFGF) using biodegradable gelatin hydrogel has been developed. Methods and Results A phase I-IIa study was performed, in which 7 patients had critical limb ischemia. They were intramuscularly injected with 200 μg bFGF-incorporated microspheres into the gastrocnemius ischemic limb. End-points safety feasibility...
The objective of this study is to investigate the feasibility a biodegradable hydrogel gelatin as controlled release carrier bone morphogenetic protein-2 (BMP-2) suitable for enhancement regeneration at segmental defect. Hydrogels with three different water contents were prepared through glutaraldehyde crosslinking an isoelectric point 9.0 under varied reaction conditions. Segmental critical-sized defects (20 mm) created ulnar skeletally mature New Zealand white rabbits, and hydrogels...