A5067172263- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Radiation Therapy and Dosimetry
- Lysosomal Storage Disorders Research
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- Carbohydrate Chemistry and Synthesis
- Medical Imaging Techniques and Applications
- Stress Responses and Cortisol
- Kruppel-like factors research
- Sinusitis and nasal conditions
- Cervical Cancer and HPV Research
- Anesthesia and Sedative Agents
- Lung Cancer Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes Treatment and Management
- Endometrial and Cervical Cancer Treatments
- Head and Neck Surgical Oncology
- Acute Myeloid Leukemia Research
- Pancreatic function and diabetes
Hokkaido University
2021-2024
Saitama University
2024
Tsurumi University
2023
Takeda (Japan)
2021-2022
Hokkaido University Hospital
2022
Jikei University School of Medicine
2021
To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated (IMRT).
Online adaptation during intensity-modulated proton therapy (IMPT) can minimize the effect of inter-fractional anatomical changes, but remains challenging because complex workflow. One approach for fast and automated online IMPT is dose restoration, which restores initial distribution on updated anatomy. However, this method may fail in cases where tumor deformation or position changes occur.To develop a robust named "deformed restoration (DDR)" that adjust changes.The DDR comprises two...
Abstract Background Gaucher disease (GD) is caused by reduced lysosomal enzyme β-glucocerebrosidase activity. Heterogeneous genotypes and phenotypes have been observed within GD types across ethnicities. Enzyme replacement therapy generally recommended for patients with type 1 GD, the least severe form of GD. In Japan, velaglucerase alfa has a broad indication covering 1, 2 or 3 Methods All 2, administered 60 U/kg every weeks via intravenous infusion after its launch date in Japan 2014, were...
Abstract Background The Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA) has not been validated use with Japanese non-small cell (NSCLC) patients brain metastasis (BM) and the factors impacting survival need to be assessed. Methods We retrospectively analyzed 294 NSCLC who were newly diagnosed BM between 2013 2020 had received radiotherapy initially at Hokkaido Cancer Center. evaluated effect on prognosis of Lung-molGPA items, expression PD-L1 (classified as...
Abstract Background Tri-weekly cisplatin and radiotherapy (CDDP + RT) is a standard of care for locally advanced head neck squamous cell carcinoma (LA-HNSCC) but sometimes challenging to complete in older patients. Weekly CDDP RT has shown mild toxicity compared tri-weekly LA-HNSCC promising option adults. We aimed report the treatment outcomes prognostic factors patients with treated weekly RT. Methods analyzed aged ≥ 70 years who started between July 2006 October 2022. includes cancer...
Abstract Background In Japan, anagrelide has been approved for use in patients with essential thrombocythemia. Here, the safety and efficacy of was assessed clinical practice as post-marketing surveillance. Subgroup analyses were conducted to compare (1) or without a history cytoreductive therapy (CRT), (2) <60 ≥60 years age, (3) an starting dose ≤0.5 mg/day 1.0 mg/day. Methods Data collected all who received anagrelide, observation period 12 months after treatment initiation. Results Of...
Sequential boost intensity-modulated radiotherapy (SQB-IMRT) uses two different planning CTs (pCTs) and treatment plans. SQB-IMRT is a form of adaptive that allows for responses to changes in the shape tumour organs at risk (OAR). On other hand, dose accumulation with plans can be difficult evaluate. The purpose this study was analyse patterns loco-regional failure using deformable image registration (DIR) hypopharyngeal cancer patients treated SQB-IMRT.Between 2013 2019, 102 were definitive...
We aimed to investigate whether daily computed tomography (CT) images could predict the gastroduodenal, small intestine, and large intestine doses of stereotactic body radiation therapy (SBRT) for pancreatic cancer based on shortest distance between gross tumor volume (GTV) gastrointestinal (GI) tract.Twelve patients with received SBRT 40 Gy in five fractions. recalculated reference clinical plan (PLANref) using CT calculated from GTV each GI tract. The maximum dose delivered 0.5 cc (D0.5cc)...
Objective Remimazolam is a new, ultra-short-acting benzodiazepine that can be used for induction and maintenance of general anesthesia. We compared the hemodynamic stability depth anesthesia during using remimazolam or propofol along with remifentanil oral maxillofacial surgery. Methods A total 95 patients were divided into groups then subdivided bispectral index (BIS) patient state (PSI) groups. Blood pressure, heart rate, BIS/PSI values at fixed time points perioperatively. Time to loss...
Most oncogenic human papilloma virus (HPV) genotypes stratify into two species, α-7 HPV and α-9 HPV. There are several studies that evaluate the relationship between species treatment outcomes reports is prognostic. The genotyping was conducted using biopsy specimens which had been stored in these studies. We study test performed by cytology less invasive more useful clinical settings. This enrolled 46 patients who received before definitive radiotherapy. results of were classified HPVα-7,...
Abstract Background: The Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA) has not yet been validated use with Japanese non-small cell (NSCLC) patients brain metastasis (BM) and the factors impacting survival need to be assessed.Methods: We retrospectively analyzed 294 NSCLC who were newly diagnosed BM between 2013 2020 received radiotherapy initially at Hokkaido Cancer Center. Lung-molGPA items, sequence of therapy, osimertinib, expression PD-L1 (classified...
The relative biological effectiveness (RBE) of proton is considered to be dependent on parameters and fractional dose. While hyperfractionated photon therapy was effective in the treatment patients with head neck cancers, its effect intensity-modulated (IMPT) under variable RBE has not been investigated detail.To study IMPT for pharyngeal cancer. We biologically dose (BED) determine theoretical schedule.The plans three cancer were used define ΔBED clinical target volume (CTV) soft tissue...
Abstract Background Gaucher disease (GD) is caused by reduced lysosomal enzyme β-glucocerebrosidase activity. Heterogeneous genotypes and phenotypes have been observed within GD types across ethnicities. Enzyme replacement therapy generally recommended for patients with Type 1 GD, the least severe form of GD. In Japan, velaglucerase alfa has a broad indication covering 1, 2 or 3 Methods All 2, administered 60 U/kg every weeks via intravenous infusion after its launch date in Japan 2014, were...