A5029561887- Advanced Radiotherapy Techniques
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Helicobacter pylori-related gastroenterology studies
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Advanced X-ray and CT Imaging
- Eosinophilic Esophagitis
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Gastroesophageal reflux and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Gut microbiota and health
- Effects of Radiation Exposure
- Chemotherapy-induced organ toxicity mitigation
Niigata University Medical and Dental Hospital
2015-2024
Niigata University
2015-2022
Kitasato University
1995-2021
Hiroshima University
2003-2019
Suzugamine Women's College
2019
Niigata Cancer Center Hospital
2015
Keiyukai Sapporo Hospital
2011-2014
Hokkaido University
2010-2013
Japan Clinical Cancer Research Organization
2013
Sapporo Medical University
2013
Background and Study Aims: Gastric carcinoid tumors are a rare disease. Previously, total gastrectomy was regarded as the treatment of choice. However, differences in biological malignancy have recently led to increased use endoscopic mucosal resection (EMR) for treatment. We studied outcome EMR patients with gastric carcinoids who were treated at our hospital discuss indications Patients Methods: Between 1986 1999 we carried out five tumors. The procedure used either strip biopsy or...
Abstract In conventional stereotactic radiosurgery (SRS), treatment of multiple brain metastases using isocenters is time‐consuming resulting in long dose delivery times for patients. A single‐isocenter technique has been developed which enables the simultaneous irradiation targets at one isocenter. This requires accurate positioning patient to ensure optimal coverage. We evaluated effect six degrees freedom (6DoF) setup errors setups on SRS distributions a technique. used simulated...
Purpose We sought to develop machine learning models detect multileaf collimator (MLC) modeling errors with the use of radiomic features fluence maps measured in patient‐specific quality assurance (QA) for intensity‐modulated radiation therapy (IMRT) an electric portal imaging device (EPID). Methods Fluence EPID 38 beams from 19 clinical IMRT plans were assessed. Plans various degrees error MLC parameters [i.e., transmission factor (TF) and dosimetric leaf gap (DLG)] positional comparison...
The evaluation of the effects Enterococcus hirae, an intestinal bacterium in adjacent mucosa (mucosal bacterium), on tumour necrosis factor-alpha (TNF-alpha)-induced barrier impairment human epithelial Caco-2 cells.The filter-grown monolayers were used as model system. In cells, heat-killed E. hirae ATCC 9790(T) suppressed TNF-alpha-induced and increase interleukin-8 (IL-8) secretion, but lipase- mutanolysin-treated did not have these effects. It was demonstrated that lipoteichoic acid (LTA)...
Purpose: We evaluated the relationship between dosimetric parameters (DPs) and incidence of radiation pneumonitis (RP) investigated feasibility a proposed treatment planning technique with potential reducing RP in esophageal cancer patients treated definitive chemoradiotherapy using extended fields. Patients Methods: A total 149 locally advanced were prospectively enrolled for extended-field radiotherapy (EFRT) to three-field regional lymphatics September 2004 June 2009. retrospectively...
Abstract The changes in dose distribution caused by backscatter radiation from a common commercial dental alloy (Au–Ag–Pd alloy; DA) were investigated to identify the optimal material and thicknesses of device (DD) for effective prevention mucositis. To this end, 1 cm3 DA was irradiated with 6-MV X-ray beam (100 MU) field size 10 × cm2 using Novalis TX linear accelerator. Ethylene vinyl acetate copolymer, polyolefin elastomer, polyethylene terephthalate (PET) selected as DD materials. depth...
Concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC) is a risk factor oral candidiasis (OC). As Candida spp. are highly virulent, we conducted retrospective study to determine whether OC increases the severity of dysphagia related mucositis in HNC patients.We retrospectively analyzed cases consecutive patients with carcinomas cavity, pharynx, larynx who underwent CCRT containing cisplatin (CDDP) at our hospital. The diagnosis was based on gross mucosal appearance. We performed...
The purpose of this study was to create and evaluate deep learning-based models detect classify errors multi-leaf collimator (MLC) modeling parameters in volumetric modulated radiation therapy (VMAT), namely the transmission factor (TF) dosimetric leaf gap (DLG).A total 33 clinical VMAT plans for prostate head-and-neck cancer were used, assuming a cylindrical homogeneous phantom, error created by altering original value TF DLG ± 10, 20, 30% treatment planning system (TPS). Gaussian filters...
Abstract Purpose We sought to develop machine learning models predict the results of patient‐specific quality assurance (QA) for volumetric modulated arc therapy (VMAT), which were represented by several dose‐evaluation metrics—including gamma passing rates (GPRs)—and criteria based on radiomic features 3D dose distribution in a phantom. Methods A total 4,250 cylindrical dummy phantom 140 arcs from 106 clinical VMAT plans extracted. obtained following metrics: GPRs with global and local...
<i>Background:</i> Serotonin receptor antagonists are recommended by the American Society of Clinical Oncology for prevention acute and delayed chemotherapy-induced emesis. However, most effective agent in this class antiemetic drugs preventing emesis has not been clearly defined. We therefore performed a double-blind, crossover, randomized, controlled trial comparing efficacy granisetron ramosetron, using patient preference as primary endpoint. <i>Methods:</i> Thirty...
A new real-time tracking radiotherapy (RTRT) system, the SyncTraX FX4 (Shimadzu, Kyoto, Japan), consisting of four X-ray tubes and ceiling-mounted flat panel detectors (FPDs) combined with a linear accelerator, was installed at Uonuma Kikan Hospital (Niigata, Japan) for first time worldwide. In addition to RTRT, system enables bony structure-based patient verification. Here we provide report this system's clinical commissioning intracranial stereotactic (SRT).A total five tests were...
Abstract Purpose We calculated the dosimetric indices and estimated tumor control probability (TCP) considering six degree‐of‐freedom (6DoF) patient setup errors in stereotactic radiosurgery (SRS) using a single‐isocenter technique. Methods used simulated spherical gross volumes (GTVs) with diameters of 1.0 cm (GTV 1), 2.0 2), 3.0 3), distance ( d ) between target center isocenter was set to 0, 5, 10 cm. created dose distribution by convolving blur component uniform distribution. The...
An antiulcer agent, ecabet sodium, is active against Helicobacter pylori. The aim of the present study was to clinically examine whether eradication therapy, which includes effective in H. pylori after failure first-line therapy.Patients with peptic ulcer who failed triple therapy containing clarithromycin received quadruple omeprazole (20 mg, twice daily), amoxicillin (750 metronidazole (500 daily) and sodium (1000 for 14 days. Eradication judged by 13C-urea breath test 8 weeks...
We describe a 54‐year‐old man who presented with right subcostal pain. Minocycline had been prescribed to treat pruritus, and the symptoms resolved. Subsequently, patient consulted local physician because of Giant folds were found in greater curvature gastric body, he was referred Department Gastroenterology, Kitasato University East Hospital. Upper gastrointestinal endoscopy revealed markedly enlarged stomach, redness edematous mucosa lesser curvature. Biopsy showed marked inflammatory cell...
There are no quantitative selection criteria for identifying high-grade glioma (HGG) patients who suited volumetric-modulated arc therapy (VMAT). This study aimed to develop that can be used the of optimal treatment modality in HGG. We analyzed 20 with HGG treated by 3D conformal radiotherapy (3DCRT). First, VMAT plans were created each patient retrospectively. For plan, normal tissue complication probability (NTCP) brain was calculated. then divided based on NTCPs 3DCRT brain, using...
(1) Background: The impacts of metal artifacts (MAs) on the contouring workload for head and neck radiotherapy have not yet been clarified. Therefore, this study evaluated relationship between time MAs area treatment planning. (2) Methods: We used planning computed tomography (CT) images radiotherapy. were classified into three severities by percentage CT containing MAs: mild (<25%), moderate (25−75%), severe (>75%). randomly selected nine patients to evaluate area. (3) Results: showed...