A5067414344- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Dysphagia Assessment and Management
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Diverticular Disease and Complications
- Cancer, Stress, Anesthesia, and Immune Response
Kawasaki Medical School
2020-2025
Kobe University
2015-2023
Okayama Prefecture
2020
Rakuwakai Otowa Hospital
2017-2018
Osaka Rosai Hospital
2018
Nippon Medical School
2018
Takeda (Japan)
2018
Kobe University Hospital
2016-2017
Kishiwada Tokushukai Hospital
2017
Osaka Medical and Pharmaceutical University
2006-2015
Summary Background Vonoprazan is a novel potassium‐competitive acid blocker which may provide clinical benefit in acid‐related disorders. Aim To verify the non‐inferiority of vonoprazan vs. lansoprazole patients with erosive oesophagitis ( EE ), and to establish its long‐term safety efficacy as maintenance therapy. Methods In this multicentre, randomised, double‐blind, parallel‐group comparison study, endoscopically confirmed LA Classification Grades A–D) were randomly allocated receive 20...
Summary Background The potassium‐competitive acid blocker vonoprazan ( VPZ ) has potent acid‐inhibitory effects and may offer clinical advantages over conventional therapy for acid‐related disorders. Aim To investigate the efficacy safety of in patients with erosive oesophagitis EO ). Methods In this multicentre, randomised, double‐blind, parallel‐group, dose‐ranging study, ≥20 years endoscopically confirmed [Los Angeles LA grades A−D] received 5, 10, 20 or 40 mg, lansoprazole LPZ 30 mg once...
There is a lack of consensus regarding the risk postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD). We examined bleeding rates and factors for from post-ESD gastric ulcers therapy. The subjects this study were 833 underwent ESD tumors. Of these, 743 not 90 some form (46 low-dose aspirin (LDA) only, 23 LDA + thienopyridine, 21 warfarin). All commenced proton pump inhibitor (PPI) immediately postoperatively. Antiplatelet agents...
To compare vonoprazan 10 and 20 mg vs lansoprazole 15 as maintenance therapy in healed erosive esophagitis (EE).A total of 607 patients aged ≥ years, with endoscopically-confirmed EE following 8 wk treatment once daily, were randomized 1:1:1 to receive (n = 201), 202), or 204), daily. The primary endpoint the study was rate recurrence during a 24-wk period. secondary at Week 12 treatment. Additional efficacy endpoints included incidence heartburn acid reflux, healing 4 after initiation...
Endoscopic submucosal dissection (ESD) is performed for treatment of various gastrointestinal lesions; however, the cecum in proximity to appendiceal orifice remains a challenging area. We reviewed our experience with cecal ESD near order clarify whether this procedure safe and effective therapeutic option.We retrospectively lesions within approximately 12 mm at Kobe University Hospital an affiliated hospital between January 2003 December 2014. Lesions were classified as: Type 0, but does...
For many patients, current treatments do not adequately resolve heartburn in nonerosive reflux disease (NERD).To compare vonoprazan and placebo with respect to the frequency severity of patients NERD.This Phase III, double-blind, placebo-controlled, parallel-group, multicenter study included Japan aged ≥20 years Grade N or M NERD recurrent acid symptoms. Patients were blinded randomized 1:1:1 receive 10 mg 20 mg. The primary efficacy outcome was proportion days without measured by patient...
One of the challenges during peroral endoscopic myotomy (POEM) is ensuring appropriate length on gastric side. To determine distal end myotomy, we focused two penetrating vessels (TPVs) found in cardia POEM. In present study, evaluated whether TPVs could serve as an accurate indicator myotomy.All patients who underwent POEM between March and August 2016 were included for this study. When making submucosal tunnel 5 o'clock direction into stomach, through circular muscle along edge oblique can...
<b>Background and study aims:</b> Improvements in the endoscopic submucosal dissection (ESD) technique have made circumferential ESD rectum possible. However, little is known about clinical course after extensive rectum. The aim of this was to determine stricture risk total or subtotal ESD. <b>Patients methods:</b> A 69 patients with rectal tumors that required ≥ 75 % resection were identified at Kobe University Hospital an affiliated hospital between April 2005 May 2014. Among patients, 61...
Background: Standard treatment for patients with erosive esophagitis (EE) is proton-pump inhibitors (PPIs), but some are resistant to PPIs. We aimed evaluate the acid-inhibitory effects and efficacy of a novel potassium-competitive acid blocker (vonoprazan) in PPI-resistant EE. Methods This randomized, double-blind, multicenter study vonoprazan evaluated gastric esophageal pH over 24-hour period as primary endpoint EE healing rate secondary endpoint. Following 7 14-day run-in (lansoprazole...
Abstract Background and Aim One of the main concerns related to peroral endoscopic myotomy (POEM) is postoperative gastroesophageal reflux (GER). The two penetrating vessels (TPVs) that are found at boundary between circular oblique muscles in posterior cardia wall have been suggested be a good indicator optimal distal extent POEM. However, effect performing using TPVs as an anatomical reference on frequency post‐POEM GER has not studied. Methods This study involved consecutive patients who...
Abstract Background and Aim: Endoscopic submucosal dissection (ESD) is reported to be a safe reliable procedure for the elderly, but these reports could have already had bias at time ESD was performed. However, not clearly stated criteria of indications. In present study, we retrospectively elucidated usefulness problems early gastric cancer in elderly patients (≥ 65 years) comparison with non‐elderly patients. Methods: The subjects were selected from 412 consecutive (515 lesions) which...
To minimize bile leakage and avoid possible death because of stent migration in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS), we have recently combined EUS-HGS with EUS-guided antegrade stenting (EUS-AS) the biliary obstruction using a novel uncovered metallic fine-gauge delivery system. In this pilot study, evaluated feasibility adverse events associated combination therapy stent.We performed 12 consecutive patients.The EUS-AS was placed across ampulla Vater 8 patients above...
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by esophageal dysfunction and eosinophilic inflammation of the mucosa. In this study, we investigated bacterial flora in saliva mucus patients with EoE examined relationship between activity mucosal cytokine expression, involving active inactive (A-EoE I-EoE, respectively). A-EoE was defined as peak eosinophil count > 15/high-power field, according to 2025 consensus guidelines. Saliva samples were collected from...
The gut microbiota plays an important role in the development of colorectal tumors. However, underlying mechanisms remain unclear. In this study, we examined effects fecal transplantation (FMT) on azoxymethane (AOM)-induced tumors obese mice. We divided study subjects into following five groups: high-fat diet (HFD), normal (ND), ND+exercise (Ex), HFD+FMT from ND-alone donor (HFD+FMT(ND alone)), and ND+Ex (HFD+FMT(ND+Ex)). Ex group performed treadmill exercise for 15 weeks. Thereafter,...
Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that chymase is involved conversion promatrix (proMMP)-9 to MMP-9. However, whether contributes activation proMMP-9 colitis has remained unclear. In this study, we administered 5% dextran sodium sulfate (DSS) solution mice for 7 days. At days after starting administration, both activity and MMP-9 were significantly increased. extract from DSS-treated mice, was increased 8...
Non-steroidal anti-inflammatory drugs (NSAIDs), which are used for the treatment of several inflammatory disorders including rheumatoid arthritis, well known to cause gastroduodenal mucosal lesions as an adverse effect. Recently, serious problem NSAID-induced small intestinal damage has become a topic great interest gastroenterologists, since capsule endoscopy and double-balloon enteroscopy available detection lesions. Such have been concern in clinical settings, their prevention must be...
Abstract Background Proton-pump inhibitors such as omeprazole are a standard treatment to prevent non-steroidal anti-inflammatory drug-induced upper gastrointestinal mucosal injuries. However, it is unclear which drugs may protect against all NSAID-induced digestive-tract Here, we compare the efficacy of gastromucoprotective drug irsogladine with in preventing esophagitis, peptic ulcers, and small-intestinal injury healthy subjects. Methods Thirty-two volunteers were assigned an group (Group...