A5101851503- Dementia and Cognitive Impairment Research
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Schizophrenia research and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Geriatric Care and Nursing Homes
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Pharmacological Effects and Toxicity Studies
- Advanced Drug Delivery Systems
- Pharmacy and Medical Practices
- Advanced Neuroimaging Techniques and Applications
- Motor Control and Adaptation
- Spatial Neglect and Hemispheric Dysfunction
- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Antifungal resistance and susceptibility
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacogenetics and Drug Metabolism
- Traumatic Brain Injury Research
- Poisoning and overdose treatments
- Sleep and related disorders
- Body Image and Dysmorphia Studies
Naragakuen University
2020-2024
Kindai University
2024
Osaka Metropolitan University
2022-2023
Nara Medical University
2022
Nara Medical University Hospital
2022
Kurashiki Central Hospital
2022
Tokyo Metropolitan University
2022
Osaka Prefecture University
2012-2021
Fujita Health University Hospital
2021
Yokkaichi Nursing and Medical Care University
2018
Left hemispatial neglect, confined to right-hand and verbal responses, was exhibited by a 56-yr-old right-handed male patient with callosal lesions due cerebral infarction. Various disconnection signs were also present. His CT MRI scans disclosed major situated in the posterior half of genu whole trunk corpus callosum, as well left medical frontal temporo-occipital lobes. neglect invariably demonstrated performance such copying drawings, line bisection, matching identical figures multiple...
Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of colitis. Recent studies have demonstrated that chymase is involved conversion promatrix (proMMP)-9 to MMP-9. However, whether contributes activation proMMP-9 colitis has remained unclear. In this study, we administered 5% dextran sodium sulfate (DSS) solution mice for 7 days. At days after starting administration, both activity and MMP-9 were significantly increased. extract from DSS-treated mice, was increased 8...
ABSTRACT Background: Patients with Alzheimer's disease (AD) manifest various impairments in eating behavior. However, few previous studies have directly investigated the gustatory function of AD patients, and results been inconsistent. Methods: Thirty-two patients (Clinical Dementia Rating (CDR) 0.5/1/2, respectively 11/15/6 patients) 22 normal control participants were examined to measure detection recognition thresholds four elemental tastes (sweet, salty, sour, bitter), their ability...
<b><i>Objective:</i></b> To investigate the gustatory function in patients with semantic dementia (SD). <b><i>Methods:</i></b> Detection and recognition thresholds of 4 basic tastes (sweet, salty, sour, bitter), taste discrimination, identification were evaluated 18 SD, Alzheimer disease (AD), 22 healthy controls. <b><i>Results:</i></b> Total detection threshold values significantly higher SD AD groups than control...
Abstract While external stimuli are given repeatedly, the level of emotional response gradually decreases. This study aims to reveal neural substrates such habituation. Fifteen healthy male volunteers were examined using [ 15 O]‐H 2 O‐PET scanning. Subjects required watch two film clips, a horror scene (emotional task) and calm (non‐emotional task). Each clip was repeatedly presented six times during 12 PET scans. The regional cerebral blood flow (rCBF) in first scans each task compared with...
In order to investigate the underlying mechanism of ideomotor apraxia, we studied 9 patients who could not mime using tools despite ability manipulate actual normally. all tasks, visually presented or model gestures by examiners were fundamentally ineffectual in improving patients’ performances. Even remarkable improvement demonstrated when disappeared immediately after subjects took their hands off them. a further experiment, 4 required pretend use while holding stick, resulting significant...
Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining function, especially profound dementia.We constructed Cognitive Test Severe Dementia (CTSD), which consists of 13 items covering 7 domains, examined its reliability validity.Cronbach's α in severe participants was 0.896. Interrater test-retest were 0.961 0.969, respectively. The CTSD showed a significant correlation with 3 other function (Mini-Mental State...
Purpose: People with dementia exhibit disturbed rest-activity rhythms and extended sleep duration issues throughout their disease. Little is known about the effects of these on clinical problems for those moderate severe dementia. This cross-sectional study aimed to examine associations activities daily living (ADL). Methods: Sleep parameters were measured using an actigraphy device. Cognitive function was assessed Mini-Mental State Examination Test Severe Dementia, Hyogo Activities Daily...
Background: The authors examined associations between physical activity, cognitive function, activities of daily living, and behavioral psychological dementia symptoms (BPSD) in severe moderate dementia. Methods: A cross-sectional study was conducted to assess groups according the Clinical Dementia Rating. An actigraphy measured activity. Other measures included Mini-Mental State Examination, Cognitive Test for Severe Dementia, Hyogo Activities Daily Living Scale, Neuropsychiatric...
Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine etiology and affected segments associated with complications, treatment, outcome.We conducted multicenter epidemiological survey using standardized data sheet Japan. Complicating PI was defined as strangulation or bowel necrosis, obstruction, adynamic ileus, sepsis, shock, massive gastrointestinal bleeding requiring blood transfusion.We enrolled 167 patients from 48...
BACKGROUND: Patients with cerebrovascular disorders (CVDs) tend to exhibit impulsive behaviour without controlling their movements, leading difficulty in performing activities of daily living and an increased risk accidents. This hastiness, termed ‘pacing impairment’, has been studied but is not fully understood. OBJECTIVE: To experimentally examine the kinetic features pacing impairment by focusing on changes speed investigating neuropsychological substrates. METHODS: We instructed 53...
Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease, and portal bacteremia is well documented ulcerative colitis (UC). However, few reports mention UC association liver abscesses. Recently, there several describing cytomegalovirus (CMV) infection disease exacerbation steroid refractoriness UC. Here we present a case of refractory accompanied multiple abscesses CMV colitis. The patient, 72-year-old male, five-year history repeated...
Background To identify the clinical factors affecting activities of daily living (ADL) at baseline and after 6 months. Methods We conducted a single‐centre observational study two time points across months (baseline months) from April 2015 to March 2017. in 270‐bed rural recuperation hospital Hyogo prefecture Japan. The total number participants was 131 (male 33, female 98; mean age: 87.0 ± 7.0; mild moderate dementia, 38; severe 93). Measurement scales used were Personal Self‐Maintenance...
The effect of zolpidem, a novel nonbenzodiazepine short-acting hypnotic, on cerebellar cyclic GMP (cGMP) and biochemical indices cerebral norepinephrine, serotonin dopamine metabolism has been investigated in the rat mouse. Zolpidem diminished levels cGMP markedly (ED50 = 0.7 mg/kg i.p.). This was antagonized, competitive manner, by benzodiazepine antagonist Ro 15-1788. zolpidem-induced decrease rapid onset short duration (less than 1 hr). When given combination with muscimol (in dose which...
Microtubule-associated protein tau has been reported to be significantly increased in cerebrospinal fluid (CSF) of the patients with Alzheimer's disease (AD), which suggests that it is possibly a biological marker for diagnosis AD. The underlying mechanism level CSF, however, not known. In this study, levels were compared between antemortem and postmortem CSF. CSF all groups including AD, neurological control, nondemented control. A striking elevation was observed during change subjects....