A5089399243- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Greenhouse Technology and Climate Control
- Light effects on plants
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Nutrition and Health in Aging
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Cardiac Imaging and Diagnostics
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Berry genetics and cultivation research
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Flowering Plant Growth and Cultivation
- Medical Imaging and Pathology Studies
- Body Composition Measurement Techniques
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Neuroendocrine Tumor Research Advances
Niigata Cancer Center Hospital
2023-2025
Toho University Medical Center Sakura Hospital
2016-2025
Niigata University
2015-2025
Toho University
2016-2025
Hirosaki University
2021-2024
Registered Nurses' Association of Ontario
2023
Hamamatsu University School of Medicine
1996-2022
Institute of Vegetable and Floriculture Science
2022
Niigata University Medical and Dental Hospital
2019-2020
Keiju Medical Center
2016
The fluid volume balance between intracellular water (ICW) and extracellular (ECW) gradually changes with age various medical conditions. Comprehension of these physiological would aid in clinical decision-making related to body assessments. A total 1,992 individuals (753 men 1,239 women) aged ≥15 yr included this study had their composition measurements performed at training gyms 2014. We developed a regression formula assess the association ratio ECW ICW subjects. mean ages male female...
Proliferator‑activated receptor‑γ (PPAR‑γ) is a nuclear receptor that acts as transcription factor in several types of tissue. PPAR‑γ ligands are known to inhibit numerous cancer cell processes, including pancreatic proliferation through terminal differentiation. Previous studies concerning the inhibitory effect derived from thiazolidinediones (TZDs) on metastatic potential cells have been reported. The present study aimed investigate whether pioglitazone, prescription TZD class drug and...
Abstract Although immune-checkpoint inhibitors (ICIs) are effective against various cancers, little is known regarding their role in salivary gland carcinoma (SGC) treatment. Therefore, we evaluated the efficacy and safety of nivolumab monotherapy patients with recurrent and/or metastatic SGC. In this multicentre retrospective study, (240 mg) was administered every 2 weeks. The overall response rate (ORR), progression-free survival (PFS), (OS), were examined; correlation between treatment...
The efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted therapy androgen deprivation (ADT) for locally advanced or recurrent metastatic (LA/RM) salivary duct carcinoma (SDC) have been reported in prospective studies. However, the survival benefit these therapies to conventional remains controversial, whether HER2-targeted ADT should be chosen HER2- (AR)-positive SDC patients unknown.
Nivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, limited rates long-term survivors (< 20%) demand robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify plasma exosome (PEX) mRNA signature, which serves as companion diagnostic nivolumab provides biological clue develop effective therapies for majority non-survivors. Pre-treatment plasmas (N = 104)...
Background/Objectives: Ankle–brachial index (ABI) is frequently measured in hemodialysis patients due to their high cardiovascular risk, while its potential role as a screening tool for assessing overall physical function and health-related quality of life (QOL) remains unclear. This study aimed evaluate the association ABI with QOL survival patients. Methods: included 346 patients, categorized into two groups based on (≤0.9 vs. >0.9). Clinical parameters, (measured using SF-36 KDQOL...
Euglycemic diabetic ketoacidosis (EuDKA) is a rare but serious complication of sodium-glucose cotransporter 2 (SGLT2) inhibitors, characterized by metabolic acidosis with near-normal blood glucose levels, making it challenging to diagnose. This case report describes 49-year-old male stage 4 chronic kidney disease (CKD) and type diabetes mellitus (T2DM) on an SGLT2 inhibitor metformin who developed EuDKA lactic following upper respiratory infection. Despite discontinuation the medications...
Salivary duct carcinoma (SDC) is a highly aggressive and uncommon tumor arising not only de novo but also in pleomorphic adenoma. Androgen receptor (AR)- HER2-targeted therapy have recently been introduced for SDC as promising treatment options; however, no predictive biomarkers yet established. EZH2 H3K27me3 are closely linked to the development progression of various cancers, expected be desirable therapeutic target. We therefore explored clinicopathological prognostic implications large...
Fluid volume overload occurs in chronic kidney disease (CKD), leading to the compensatory release of natriuretic peptides. However, elevated cardiac peptides may also be associated with malnutrition as well overload.Body fluid composition was measured 147 patients CKD between 2009 and 2015, its relationship brain peptide (BNP) levels examined. Body separated into three components: (a) a water-free mass consisting muscle, fat, minerals; (b) intracellular water (ICW) content, (c) extracellular...
Objectives/Hypothesis To assess the ability of near‐infrared fluorescence imaging (NIFI) to identify parathyroid glands (PGs) among histologically proven PG/non‐PG specimens compared with a surgeon's visual acumen, and determine NIFI sensitivity in detecting incidentally resected PGs from thyroidectomy specimens, inspection. Study Design Prospective study. Methods With mean age 61 years, 36 patients various thyroid diseases were enrolled. Possible (n = 28) lymph nodes 32) identified by...
Natriuretic peptides are associated with malnutrition and volume overload. Over-hydration cannot simply be explained by excess extracellular water in patients undergoing hemodialysis. We assessed the relationship between intracellular (ECW/ICW) ratio, N-terminal pro-B-type natriuretic peptide (NT-proBNP), human atrial (hANP), echocardiographic findings. Body composition was examined segmental multi-frequency bioelectrical impedance analysis 368 maintenance dialysis (261 men 107 women; mean...
Abstract Background Salivary duct carcinoma (SDC) is a high‐grade adenocarcinoma with 5‐year survival rate of 40%. Although drug therapy has improved patients' prognosis, the impact brain metastasis (BM) remains poorly understood. We aimed to retrospectively examine incidence BM in patients SDC ( n = 464) and develop tool estimate their prognoses. Methods examined 464 enrolled multicenter study. investigated BM, overall (OS) rates, factors affecting prognosis BM. also developed an SDC‐graded...
Small nerve fibres located in the epidermis sense pain. Dysfunction of these decreases pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting These findings suggest that various may be involved Herein, we explored correlation between sensation and plasma metabolites healthy Japanese subjects. The evaluated from intraepidermal electrical stimulation was used to quantify a total 1021 individuals 2017...
Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in foot, suggesting that abundance gut Gram-negative bacilli, which a source lipopolysaccharides, may be involved development DPN. Furthermore, and oral microbiota assumed to pathogenesis diabetes. Nevertheless, association between SFN has not been clarified. A total 1056 individuals were recruited 2018 Iwaki...
Objective Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) treatment has changed dramatically with the introduction of immune checkpoint inhibitors (ICIs). However, there are few reports outcomes on HNSCC distant metastasis (M1) at initial diagnosis, its strategy not been standardized. We aimed to analyze outcome prognostic factors patients M1 disease. Methods In this multi‐institutional retrospective study, 98 were initially diagnosed disease between 2007 2021. The divided...
Background Arsenic trioxide (As2O 3) is a new promising regimen for patients with relapse of acute promyelocytic leukemia (APL), but causes life-threatening arrhythmias. This study aimed to investigate the incidence and mechanism arrythmogenesis caused by As2O3. Methods Results Standard 12-lead ECGs were monitored throughout As2O3 therapy in 20 APL patients. As2O 3 (0.15 mg/kg) significantly prolonged corrected QT interval (QTc: 445±7 517±17 ms, means±SE, p<0.01), also increased QTc...
The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in Chubu region Japan from 2006 2015, compared with previous reports. A retrospective analysis was conducted based on medical records 40 hospitals located central Japanese main island, a population around 22.66 million individuals. This designed line two studies into NPC same area Japan. We recruited patients diagnosed across this over 10-year period (2006-2015) using questionnaire about...
There are no reports showing the significance and effective range of dissection for patients with lateral lymph node metastasis (LLNM). This study aimed to investigate indications (LLND) in LLNM based on prognostic factors recurrence types.
Abstract Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive molecular profiling to discover novel SDC. A total of 67 SDC samples were examined with DNA sequencing 464 genes transcriptome analysis combination the clinicopathological characteristics individuals. Prognostic associated response combined androgen blockade (CAB) treatment explored using mRNA expression data from 27 cases. Oncogenic...