A5070240329- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ocular Surface and Contact Lens
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Soft tissue tumor case studies
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Metastasis and carcinoma case studies
- Urinary and Genital Oncology Studies
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Urologic and reproductive health conditions
Teikyo University Chiba Medical Center
2015-2024
Japan Fisheries Research and Education Agency
2020
University Medical Center
2016
Teikyo University
2002-2016
Keio University
1993-2011
Saiseikai Central Hospital
2001-2010
Tachikawa Hospital
2009
St. Luke's International Hospital
2009
National Hospital Organization
2009
Tokyo Metropolitan Hiroo Hospital
2009
A myocardial bridge (MB) that partially covers the course of left anterior descending coronary artery (LAD) sometimes causes ischemia, primarily because hemodynamic deterioration, but without atherosclerosis. However, mechanism occurrence infarction (MI) as a result an MB in patients with spontaneously developing atherosclerosis is unclear.One hundred consecutive autopsied MI hearts either MBs [MI(+)MB(+) group; n=46] or (n=54) were obtained, 200 normal hearts, 100 [MI(-)MB(+) group] and...
Our present study of the microRNA (miRNA) expression signature in castration-resistant prostate cancer (CRPC) revealed that clustered miRNAs microRNA-221 (miR-221) and microRNA-222 (miR-222) are significantly downregulated tissues. The aim this was to investigate functional roles miR-221 miR-222 (PCa) cells.A CRPC miRNA constructed by PCR-based array methods. Functional studies differentially expressed were analysed using PCa cells. association between overall survival estimated Kaplan-Meier...
In the human genome, miR-451a, miR-144-5p (passenger strand), and miR-144-3p (guide strand) reside in clustered microRNA (miRNA) sequences located within 17q11.2 region. Low expression of these miRNAs is significantly associated with poor prognosis patients renal cell carcinoma (RCC) (miR-451a: P = .00305; miR-144-5p: .00128; miR-144-3p: 9.45 × 10-5 ). We previously reported that miR-451a acted as an antitumor miRNA RCC cells. Involvement passenger strand miR-144 duplex pathogenesis not well...
Despite recent advancements, metastatic castration-resistant prostate cancer (CRPC) is not considered curative. Novel approaches for identification of therapeutic targets CRPC are needed. Next-generation sequencing revealed 945–1248 miRNAs from each lethal mCRPC sample. We constructed miRNA expression signatures by comparing the between and normal tissue or hormone-sensitive (HSPC). Genome-wide gene studies in silico analyses were carried out to predict regulation investigate functional...
We propose the designation 'sialolipoma' to establish and characterize a new category of benign lipomatous tumour occurring in salivary glands. Until now, these tumours have not been regarded as distinct entity evaluated clinicopathological immunohistochemical features seven sialolipomas among 2051 surgically resected primary gland deposited our files. The patients with sialolipoma were five men two women, aged 20–75 years (mean: 54.4 years). Five had arisen parotid gland, one soft palate,...
In order to extend our understanding of the role nerve fibers in structure and function bone marrow stroma, we have examined terminals, arterioles, capillaries femoral tissues 50 C57BL strain mice, using electron microscopy morphometric methods. Within adventitia a particular type cell, termed periarterial adventitial (PAA) is characterized by thin veil-like cytoplasm which concentrically surrounds both nerves arterioles. Nerve containing unmyelinated myelinated axons are distributed mainly...
Neuronal function and innervation density is regulated by target organ-derived neurotrophic factors. Although cardiac hypertrophy drastically alternates the expression of various growth factors such as endothelin-1, angiotensin II, leukemia inhibitory factor, little known about nerve factor its effect on sympathetic nerves. This study investigated impact pressure overload-induced cellular nerves, including kinetics norepinephrine synthesis reuptake, neuronal gene expression. Right...
MYD88 and CD79B mutations that activate nuclear factor (NF)-κB signaling are prevalent in subsets of diffuse large B-cell lymphoma (DLBCL). We examined the prevalence somatic Toll/interleukin-1 receptor (TIR) domain tyrosine-based activation motif (ITAM) CD79A/B 18 primary central nervous system (CNS) DLBCLs, their immunoprofile. mutation was found 17 cases (94.4%), all which were L265P substitutions. 11 (61.1%), 10 (55.6%) Y196C/D/H Mutation CD79A completely absent. Immunohistochemically,...
Abstract Effective treatments for patients with castration‐resistant prostate cancer ( CRPC ) have not yet been established. Novel approaches identification of putative therapeutic targets are needed. Analyses RNA sequencing micro (mi expression revealed that miR‐99a‐3p (passenger strand) is significantly downregulated in several types cancers. Here, we aimed to identify novel regulatory networks and . Ectopic inhibited cell proliferation, migration, invasion PC a cells. Non‐ SMC condensin I...
Molecular targeted therapy is a standard treatment for patients with advanced renal cell carcinoma (RCC). Sunitinib one of the most common molecular-targeted drugs metastatic RCC. mechanisms sunitinib resistance in RCC cells still ambiguous. The microRNA (miRNA) expression signature failure was constructed using polymerase chain reaction (PCR)-based array. Several miRNAs that were aberrantly expressed tissues from treated identified this analysis. MicroRNA-101 (miR- 101) markedly suppressed...
To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating expression surface molecules associated T-cell activation.Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical analysis biopsy specimens obtained from nine cGVHD five Sjögren's syndrome (SS). The regions interest further assessed transmission electron microscopy.CD4(+) CD8(+) T cells mainly detected periductal areas...
Analysis of our original micro RNA (mi ) expression signature patients with advanced renal cell carcinoma ( RCC showed that ‐10a‐5p miR‐10a‐5p was significantly downregulated in specimens. The aims the present study were to investigate antitumor roles and novel cancer networks regulated by this mi cells. Downregulation confirmed tissues from treated tyrosine kinase inhibitors TKI ). Ectopic lines (786‐O A498 cells) inhibited migration invasion. Spindle kinetochore‐associated protein 1 SKA...
Recent analyses of our micro RNA (mi ) expression signatures obtained from several types cancer have provided novel information on their molecular pathology. In renal cell carcinoma ( RCC ), ‐451a miR‐451a was significantly downregulated in patient specimens and low associated with poor prognosis patients P = .00305) based data The Cancer Genome Atlas. aims the present study were to investigate antitumor roles identify oncogenic networks it regulated cells. Ectopic inhibited migration...
Objectives To identify key oncogenes and proteins that are controlled by the microRNA miR‐29 family ( miR‐29a , miR‐29b miR‐29c ) in renal cell carcinoma pathogenesis. Methods Genome‐wide gene expression silico database analyses were carried out. The Cancer Genome Atlas was used to investigate clinical significance of data patients. Loss‐of‐function assays applied function target genes. Results We identified 47 possible genes might be regulated cells. Among targets family, high 10 ADAMTS14,...
Salivary duct carcinoma (SDC) is an uncommon, high-grade tumor. We present 8 cases of sarcomatoid SDC, which has been defined recently as a rare variant SDC. The patients (5 men, 3 women) had mean age 63.6 years. Histologically, all tumors were characterized by biphasic neoplasm composed both SDC and elements. In cases, components showed osteosarcomatous heterologous differentiation. A residual pleomorphic adenoma was detected in 5 tumors. component focal immunoreactivity for cytokeratin 4...
To predict a malignant grade of lung cancer by fluorodeoxyglucose positron emission tomography (FDG-PET) scanning, we investigated the correlation between FDG uptake and pathological tumor stage, proliferative activities determined Ki-67 cyclin D1, an alteration p53, in clinical stage (c-stage) IA adenocarcinomas.FDG-PET was performed for 71 patients with c-stage adenocarcinomas. measured contrast ratio (CR) contralateral lung. Ki-67, D1 p53 staining scores were examined...