A5067494948- Fungal and yeast genetics research
- Ovarian cancer diagnosis and treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Folate and B Vitamins Research
- Coronary Artery Anomalies
- Marine Sponges and Natural Products
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Transgenic Plants and Applications
- Platelet Disorders and Treatments
- Insect Resistance and Genetics
- Gallbladder and Bile Duct Disorders
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Chromatin Remodeling and Cancer
- Genetics, Aging, and Longevity in Model Organisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Amino Acid Enzymes and Metabolism
- Genomics and Chromatin Dynamics
- Cardiac tumors and thrombi
- Microbial Metabolic Engineering and Bioproduction
- Catalytic Alkyne Reactions
- Advanced Glycation End Products research
- Biological Activity of Diterpenoids and Biflavonoids
Showa University Fujigaoka Hospital
2021-2025
Hiroshima University
2013-2024
Joslin Diabetes Center
2022-2024
Harvard Stem Cell Institute
2022-2024
Harvard University
2022-2023
Utsunomiya University
2020
Kobe University
1996-2017
Tokai University
2014-2016
Tokai University Tokyo Hospital
2014-2016
Tokyo Institute of Technology
2015
Exercise is a nonpharmacological intervention that improves health during aging and valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently alters mitochondrial functionality metabolism. Mitochondrial fission fusion are critical effectors plasticity, which allows fine-tuned regulation organelle connectiveness, size, function. Here we have investigated role dynamics model organism Caenorhabditis elegans. We show body-wall single session induces cycle...
A myocardial bridge (MB) that partially covers the course of left anterior descending coronary artery (LAD) sometimes causes ischemia, primarily because hemodynamic deterioration, but without atherosclerosis. However, mechanism occurrence infarction (MI) as a result an MB in patients with spontaneously developing atherosclerosis is unclear.One hundred consecutive autopsied MI hearts either MBs [MI(+)MB(+) group; n=46] or (n=54) were obtained, 200 normal hearts, 100 [MI(-)MB(+) group] and...
The transport of solutes between blood and brain is regulated by a specific barrier. Capillary endothelial cells are known to mediate barrier function facilitate transport. Here we report that surrounding arterioles, as Mato's fluorescent granular perithelial (FGP) or perivascular microglial cells, contribute the function. Immunohistochemical in situ hybridization studies indicate that, normal cortex, type I II macrophage scavenger receptors expressed only FGP/perivascular surface markers...
The biological effects of far-infrared ray (FIR) on whole organisms remain poorly understood. aim our study was to investigate not only the hyperthermic effect FIR irradiation, but also wound healing. To evaluate a skin site, speed full-thickness healing compared among groups with and without using rat model. We measured area, blood flow, temperature before during we performed histological inspection. Wound significantly more rapid than FIR. Skin flow did change or irradiation. Histological...
Small cell carcinoma of the ovary, pulmonary type (SCCOPT), is a rare and aggressive malignancy with poor prognosis. We report case this cancer in patient germline BRCA2 (gBRCA2) mutation. A 66-year-old female presented abdominal distention, underwent laparotomy, was diagnosed stage IVB SCCOPT. Histopathological examination revealed no other ovarian tumor components. Adjuvant platinum-based chemotherapy administered, followed by maintenance therapy poly(ADP-ribose) polymerase inhibitors...
Dietary restriction (DR), such as calorie (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to beneficial effects DR, molecular mechanism underlying key responsible for DR regimens is not fully understood. Here we show stimulating S-adenosyl-l-methionine (AdoMet) synthesis extended budding yeast Saccharomyces cerevisiae The AdoMet synthesis-mediated metabolic effects, which resulted from...
Abstract Methionine restriction (MetR) can extend lifespan and delay the onset of aging‐associated pathologies in most model organisms. Previously, we showed that supplementation with metabolite S ‐adenosyl‐L‐homocysteine (SAH) extends activates energy sensor AMP‐activated protein kinase (AMPK) budding yeast Saccharomyces cerevisiae . However, mechanism involved whether SAH metazoan have remained unknown. Here, show reduces Met levels recapitulates many physiological molecular effects MetR....
Abstract Purpose To retrospectively evaluate the diagnostic potential of magnetic resonance imaging (MRI)-based features and radiomics analysis (RA)-based for discriminating ovarian clear cell carcinoma (CCC) from endometrioid (EC). Materials methods Thirty-five patients with 40 ECs 42 43 CCCs who underwent pretherapeutic MRI examinations between 2011 2022 were enrolled. MRI-based two groups compared. RA-based extracted whole tumor volume on T2-weighted images (T2WI), contrast-enhanced...
The Start/G1 phase in the cell cycle is an important period during which cells determine their developmental fate, onset of mitotic progression, or switch to stages response both external and internal signals. In budding yeast Saccharomyces cerevisiae, Whi3, a negative regulator G1 cyclins, has been identified as positive size control involved regulation Start. However, regulatory pathway Whi3 governing multiple signals remains largely unknown. Here, we show that phosphorylated by...
The Bacillus subtilis genome (BGM) vector is a novel cloning system based on the natural competence that enables B. to import extracellular DNA fragments into cell and incorporate recombinogenic by homologous recombination. BGM has several attractive properties, such as megabase capacity, stable propagation of cloned inserts, various modification strategies using RecA-mediated However, endogenous RecA activity may cause undesirable recombination, been observed in yeast artificial chromosome...
RUNX3 is a novel tumor suppressor in gastric carcinogenesis and an important factor for differentiation of chief cells the normal fundic mucosa. In this study, we confirmed immunolocalization gland (bottom part) but minimum surface mucous cell epithelium (top isolated from We also analyzed expression by immunohistochemistry 102 cancers made histological assessment markers to evaluate interrelations. Among them, 45 57 cases were judged be positive negative, respectively, 33 69 pepsinogen I...
Abstract We investigated whether β‐amyloid (Aβ)‐like immunoreactivity was seen in the brains of newborn piglets. The for Aβ(1‐42) and Aβ(1–40) proteins, but not Aβ precursor protein, present CD68‐positive perivascular cells hippocampus parts meninges. It colocalized with receptor advanced glycation end product tumor necrosis factor‐α. protein a molecular mass 27 kDa, which recognized by antibodies, identified as triosephosphate isomerase (TPI) sequence homology to peptides N ‐terminal amino...
Rhabdoid differentiation is an indicator of poor prognosis that often seen in renal cell carcinoma; however, it also rarely non-renal tumours. Therefore, pathologists should carefully review this finding and report. This report describes the first case a seminoma testicular origin developed rhabdoid differentiation.
An 84-year-old man was referred to the emergency department with severe dyspnea. Based on his physical findings, electrocardiogram, X-ray and echocardiographic congestive heart failure suspected drip infusion of prophylactic heparin against intracardiac thrombosis commenced together dopamine, nitroglycerin furosemide. Diuresis occurred pulmonary congestion ameliorated remarkably. Starting 20th hospital day, platelet count gradually reduced (from 256,000 55,000 /μl) fibrin degradation product...