A5091409148- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Frailty in Older Adults
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Allergic Rhinitis and Sensitization
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
Showa University Fujigaoka Hospital
2016-2025
Respiratory Clinical Trials
2021
Showa University
2007-2019
Showa University Hospital
2019
University of California, San Diego
2016-2018
Kagawa University
1991-2013
Daiichi-Sankyo (Japan)
2012
Chiba University
1991-1993
Daiichi Kogyo Seiyaku (Japan)
1988
Virginia Commonwealth University Medical Center
1980
Regional cerebral blood flow measured in patients with dementias (N = 60) using xenon Xe 133 inhalation was compared measurements health volunteers 70). Volunteers were age-matched 15); another group younger. In normal aging, there is progressive, diffuse reduction of weight and gray matter (F1) but not white matter. Therefore, control subjects are necessary studies dementia. Alzheimer's disease (AD), F1 shows bilateral symmetrical reduction. The correlated atrophy estimated by computerized...
We aimed to assess the frequency of acute kidney injury (AKI) in different areas under concentration-time curve (AUC) values vancomycin (VAN) using a two-point blood collection method, allowing for accurate AUC assessment critically ill patients. This multicenter retrospective observational study was conducted eight hospitals. retrospectively analyzed data patients who had received VAN an intensive care unit (ICU) between January 2020 and December 2022. The primary outcome incidence AKI....
Atherosclerosis and osteoporosis are epidemiologically linked oxidation specific epitopes (OSEs), such as phosphocholine (PC) of oxidized phospholipids (PC-OxPL) malondialdehyde (MDA), pathogenic in both. The proatherogenic effects OSEs opposed by innate immune antibodies. Here we show that high-fat diet (HFD)-induced bone loss is attenuated mice expressing a single chain variable region fragment the IgM E06 (E06-scFv) neutralizes PC-OxPL, increasing osteoblast number stimulating formation....
SUMMARY A significant percentage (6.4%) of healthy subjects was found to contain anti-thyroid peroxidase (TPO) antibodies in their sera. However, contrast with IgG from sera patients chronic thyroiditis, did not inhibit TPO activities both guaiacol and iodide assays. In addition, anti-TPO block the inhibition enzyme by patients. These findings suggest that do bind epitopes relating substrate-combining sites TPO. Thus, specificities may differ those cases thyroiditis.
The purpose of the present study was to report cases epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-naïve patients carrying a mutation associated with acquired resistance drug. Gene alterations in 77 lung carcinoma were analyzed by collecting and studying curette lavage fluid at time diagnosis. PCRs performed amplify hotspot regions EGFR genes. PCR products direct-sequenced mutations confirmed resequencing using different primers. Case 1 78-year-old Japanese male...
Aim Frailty and sarcopenia affect the prognosis quality of life patients with chronic obstructive pulmonary disease (COPD). However, it remains uncertain which model is most suitable for evaluating vulnerability in COPD. We evaluated validity three frailty models – Kihon Checklist (KCL), Japanese version Cardiovascular Health Study Osteoporotic Fractures one older Methods This cross‐sectional study included 201 (aged ≥65 years) outpatients used to identify their correlation various indices...
Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment bronchodilators, nutritional support, and rehabilitation for frailty COPD, none addressed traditional Japanese medicine (Kampo medicine). Herein, we report successful management using Ninjin'yoeito therapy 76-year-old patient COPD. Despite being prescribed multiple supplement therapy, education, rehabilitation,...
MicroRNAs are non-coding small RNAs that regulate expression of target genes by binding to 3′ untranslated regions. In this study, we used bronchial epithelial cells investigate in vitro the role microRNA miR-155 chemokines associated with airway inflammation. has previously been reported allergic BEAS-2B were cultured and transfected mimic or inhibitor oligonucleotides overexpress downregulate miR-155, as confirmed real-time PCR. Cells then stimulated tumor necrosis factor-alpha,...
We herein report a case of squamous cell transformation combined with the epidermal growth factor receptor (EGFR) mutation T790M associated acquired resistance to EGFR tyrosine kinase inhibitors (EGFR‑TKIs) in 73‑year‑old male patient diagnosed stage IVA lung adenocarcinoma. Gene alterations were analyzed by collecting and studying pleural effusion at time diagnosis. Examination revealed an exon 19 deletion gene. Following treatment second‑generation EGFR‑TKI afatinib, carcinoma was...
Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), immediately became a pandemic. Therefore, nosocomial infection control is necessary to screen for patients with possible COVID-19. Objective: This study aimed investigate commonly measured clinical variables predict Methods: cross-sectional enrolled 1087 in the isolation ward of university hospital. Conferences were organized differentiate COVID-19 from non-COVID-19 cases,...
The emergence of the Omicron variant severe acute respiratory syndrome coronavirus-2 has significantly altered clinical features and severity coronavirus disease 2019 (COVID-19).
A worldwide increase in the Mycobacterium abscessus (M. abscessus) complex has been observed. Therefore, aim of present study was to investigate diversity rrl and erm(41) genes, both which are associated with macrolide sensitivity M. complex. The current also examined efficacy mass spectrometry as an alternative molecular testing classify subspecies total 14 strains were obtained, based on conventional analyses using housekeeping 57% determined be subsp. abscessus, 43% massiliense, none...
Anlotinib demonstrated improved overall survival (OS) and progression-free (PFS) compared with placebo as a third-line or subsequent therapy in patients non-small cell lung cancer (NSCLC) the ALTER0303 trial. The status of epidermal growth factor receptor (EGFR) mutation, different previous treatment may affect efficacy therapy, we did this subgroup analysis to characterize anlotinib without EGFR mutation.The trial was randomized, double-blind, phase 3 study NSCLC who failed at least 2 lines...
1. Viegi G, Scognamiglio A, Baldacci S, Pistelli F, Carrozzi L. Epidemiology of chronic obstructive pulmonary disease (COPD). Respiration. 2001;68:4-19. doi:10.1159/000050456. CrossRef Google Scholar
As antibiotic resistance has become a global problem, the intervention of an antimicrobial stewardship team (AST) is warranted. In hematological disorders, infectious complications are crucial owing to abnormal neutrophil function and decreased cell-mediated immunity. Despite widespread implementation AST intervention, effectiveness practices for immunocompromised patients remains uncertain. We determined effect interventions on carbapenem therapy in department hematology. Patients admitted...