A5013474229- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Dysphagia Assessment and Management
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Biosimilars and Bioanalytical Methods
- Evaluation and Performance Assessment
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
Showa University Hospital
2024-2025
Showa University Northern Yokohama Hospital
2022-2025
Showa University
2024-2025
We aimed to assess the frequency of acute kidney injury (AKI) in different areas under concentration-time curve (AUC) values vancomycin (VAN) using a two-point blood collection method, allowing for accurate AUC assessment critically ill patients. This multicenter retrospective observational study was conducted eight hospitals. retrospectively analyzed data patients who had received VAN an intensive care unit (ICU) between January 2020 and December 2022. The primary outcome incidence AKI....
Abstract Background Population pharmacokinetic (PPK) models of vancomycin (VCM) commonly use creatinine clearance (CLcr) as a covariate for (CL). However, relying on CLcr in patients advanced age may lead to inaccuracies estimating VCM clearance. Therefore, this study aimed develop and validate new PPK model specifically aged 75 years older. Methods analysis was performed based the blood concentrations ( n = 159 patients). The predictive performance developed compared with that previous...