A5069957717- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Genomics, phytochemicals, and oxidative stress
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
Harvard Stem Cell Institute
2016-2024
Harvard University
2016-2024
Joslin Diabetes Center
2016-2024
Universidad Nacional Autónoma de México
2017
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty (FA), promotes health and longevity. Here, we show that OA benefits Caenorhabditis elegans by activating endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in homeostasis response. SKN-1A/Nrf1 cleared from ER ER-associated degradation (ERAD) machinery stabilized when proteasome activity low...
When the electrochemical proton gradient is disrupted in mitochondria, IF1 (Inhibitor Factor-1) inhibits reverse hydrolytic activity of F1Fo-ATP synthase, thereby allowing cells to conserve ATP at expense losing mitochondrial membrane potential (Δψm). The function has been studied mainly different cell lines, but these studies have generated contrasting results, which not helpful understand real role this protein a whole organism. In work, we Caenorhabditis elegans IF1´s vivo. C. two...
Summary The d4 family of transcription factors consists three members in mammals. DPF1/neuro‐d4 is expressed mainly neurons and the peripheral nervous system, important for brain development. DPF2/requiem/ubi‐d4 ubiquitously presumably functions as an apoptotic factor, especially during deprivation trophic factors. DPF3/cer‐d4 heart, heart development function zebrafish. In Drosophila , there only one member, dd4, whose still unknown, but it many tissues particularly abundant developing...
Abstract Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty (FA), promotes health and longevity. Here we show that OA benefits C. elegans by activating endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in homeostasis response. SKN-1A/Nrf1 cleared from ER ER-associated degradation (ERAD) machinery stabilized when proteasome activity low, canonically...