A5035669734- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Plant Gene Expression Analysis
- Circadian rhythm and melatonin
Joslin Diabetes Center
2023
Harvard University
2023
Harvard Stem Cell Institute
2023
California University of Pennsylvania
2012
University of Pennsylvania
2011
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty (FA), promotes health and longevity. Here, we show that OA benefits Caenorhabditis elegans by activating endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in homeostasis response. SKN-1A/Nrf1 cleared from ER ER-associated degradation (ERAD) machinery stabilized when proteasome activity low...
The molecular mechanisms of animal cell osmoregulation are poorly understood. Genetic studies in yeast have identified mucin-like proteins as critical regulators osmosensitive signaling and gene expression. Whether mucins play similar roles higher organisms is not known. Here, we show that mutations the Caenorhabditis elegans osm-8 specifically disrupt osmoregulatory physiological processes. In mutants, normal responses to hypertonic stress, such accumulation organic osmolytes activation...
Summary Membrane proteins comprise ~30% of the proteome. During early stages maturation, this class can experience localized misfolding in distinct cellular compartments, such as cytoplasm, endoplasmic reticulum (ER) lumen, and ER membrane. quality control (ERQC) mechanisms monitor folding determine whether a membrane protein is appropriately folded or misfolded warrants degradation. ERQC plays critical roles human diseases, cystic fibrosis, where deletion single amino acid (F508) results...