A5102990759- Reconstructive Surgery and Microvascular Techniques
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Lung Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Wound Healing and Treatments
- Lung Cancer Treatments and Mutations
- Venous Thromboembolism Diagnosis and Management
- Reconstructive Facial Surgery Techniques
- Liver Disease Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Amino Acid Enzymes and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dermatologic Treatments and Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Renal and related cancers
- Gout, Hyperuricemia, Uric Acid
- Tracheal and airway disorders
- Facial Nerve Paralysis Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Burn Injury Management and Outcomes
- Nerve injury and regeneration
- Medical Imaging and Pathology Studies
- Gallbladder and Bile Duct Disorders
Nihon University
2014-2025
Tokyo Women's Medical University
2015-2024
Kyorin University
2014-2024
Waseda University
2024
Tokyo Medical Center
2024
National Hospital Organization
2024
Osaka City General Hospital
2023-2024
Keio University
2024
Mie University
2013-2022
Creative Commons
2014-2021
Hyperuricemia is a significant factor in variety of diseases, including gout and cardiovascular diseases. Although renal excretion largely determines plasma urate concentration, the molecular mechanism handling remains elusive. Previously, we identified major reabsorptive transporter, URAT1 (SLC22A12), on apical side proximal tubular cells. However, it not known how taken up by exits from cell to systemic circulation. Here, report that sugar transport facilitator family member protein GLUT9...
The pathologic features of invasion such as stromal disruption and pleural/vascular involvement have been shown to be prognostic value in adenocarcinoma. However, the relationship between degree invasion, histologic subtype adenocarcinoma, prognosis remains unclear. We retrospectively studied 380 peripheral adenocarcinomas ≤2.0 cm diameter with regard histology clinical profiles. Their invasive growth was classified into four grades follows according structural deformity its location...
Purpose: To retrospectively evaluate the long-term results of radiofrequency (RF) ablation combined with chemoembolization (combination therapy) as compared hepatectomy for treatment early-stage hepatocellular carcinoma (HCC). Materials and Methods: The study was approved by institutional review board, informed consent waived. Patients HCC were included if they underwent either combination therapy or met following inclusion criteria: no previous HCC, three fewer tumors a maximum diameter 3...
The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated serum uric acid (urate). Uricase may have been beneficial to early primate survival. However, an predisposed man hyperuricemia, a metabolic disturbance leading gout, hypertension, and various cardiovascular diseases. Human levels are largely determined by reabsorption secretion the kidney. Renal is controlled via two proximal tubular transporters: apical URAT1 (SLC22A12) basolateral URATv1/GLUT9...
l-3-(18)F-α-methyl tyrosine ((18)F-FAMT) has been developed as a PET radiotracer for tumor imaging. Clinical studies have demonstrated the usefulness of (18)F-FAMT prediction prognosis and differentiation malignant tumors benign lesions. exhibits higher cancer specificity in peripheral organs than other amino acid tracers (18)F-FDG. The accumulation is strongly correlated with expression L-type transporter 1 (LAT1), an isoform system L highly upregulated cancers. In this study, we examined...
Various tumors express programmed cell death ligand 1 (PD-L1), an immune checkpoint ligand, the expression of which correlates with certain effects anti-programmed (PD-1)/PD-L1 drugs. The aim this study was to assess frequency PD-L1 in each types neuroendocrine lung.The subjects enrolled were patients who had been diagnosed lung and treated at National Cancer Center Hospital (Tokyo, Japan) between 1982 2010. We performed immunohistochemical analysis on a tissue microarray (TMA) surgical...
Epigenetic mechanisms may underlie the progression of diabetic kidney disease. Because is a heterogeneous organ with different cell types, we investigated DNA methylation status in type-specific manner. We first identified genes specifically demethylated normal proximal tubules obtained from control db/m mice, and next delineated candidate disease-modifying bearing aberrant induced by diabetes using db/db mice. Genes involved glucose metabolism, including Sglt2, Pck1, G6pc, were selectively...
Whether mesenchymal–epithelial interactions leading to branching morphogenesis in developing epithelial tissues such as the kidney require direct cell–cell contact or are due soluble mediators elaborated by inducing tissue has been subject of much debate. Here we demonstrate that ureteric bud (UB) epithelium, from which collecting system and upper urinary tract derived, can undergo impressive three-dimensional when cultured appropriate extracellular matrix context absence with mesenchymal...
Interactions between the ureteric bud (UB) and metanephric mesenchyme are crucial for tubulogenesis during kidney development. Two immortalized cell lines derived from day 11.5 embryonic kidney, UB cells, which appear to be epithelial (cytokeratin-positive, E-cadherin-positive, ZO-1-positive by immunostaining) BSN largely mesenchymal (vimentin-positive, but negative cytokeratin, surface E-cadherin, ZO-1), were used establish an in vitro system. cells expressed hepatocyte growth factor (HGF)...
Using in vivo bromodeoxyuridine (BrdU) labeling, a tubular cell population (label-retaining cells [LRTC]) was identified recently normal adult kidneys, which contributes actively to the regeneration process of kidney after injury. Here, these LRTC are characterized vitro. The isolated from BrdU-treated rat by FACS. Both and non-LRTC underwent proliferation maintained an epithelial phenotype presence tubulogenic growth factors such as EGF, TGF-alpha, IGF-I, hepatocyte factor. It is...
Abstract Background and Objective Fractional resurfacing is a new concept of cutaneous remodeling whereby laser‐induced zones microthermal injury are surrounded by normal untreated tissue. The aim this study to compare the efficacy complications Fraxel laser treatment when using different fluences density settings. Study Design/Materials Methods Thirty female Asian patients were enrolled in study. Group 1 ( n = 10); half face was treated with eight passes at 125 MTZ/cm 2 an energy setting 8...
Abstract BACKGROUND Recently, molecular therapies targeting epidermal growth factor receptor (EGFR) have been developed for clinical use. The current study was conducted to determine 1) the exact frequency of EGFR protein overexpression, 2) correlation between overexpression and amplification, 3) status genetic clinicopathologic features in nonsmall cell lung carcinomas (NSCLC). METHODS In total, 181 NSCLC samples were examined immunohistochemically using an antibody against EGFR, tumor...
Many genome-wide association studies pointed out that SLC2A9 gene, which encodes a voltage-driven urate transporter, SLC2A9/GLUT9 (a.k.a. URATv1), as one of the most influential genes for serum levels. is reported to encode two splice variants: SLC2A9-S (512 amino acids) and SLC2A9-L (540 acids), only difference being at their N-termini. We investigated isoform-specific localization in human kidney role N-terminal acids differential sorting vitro.Isoform specific antibodies against were...
We investigated the pathophysiological alterations seen with combined burn and smoke inhalation injuries by focusing on pulmonary vascular permeability cardiopulmonary function compared those either or injury alone. To estimate effect of factors other than injury, experiments were also performed no in same experimental setting. Lung edema was most severe group. Our study revealed that does not affect protein leakage from microvasculature, even when is associated injury. The severity lung...