A5004609431- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Voice and Speech Disorders
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Dysphagia Assessment and Management
- Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Colorectal and Anal Carcinomas
- Phonetics and Phonology Research
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Otolaryngology and Infectious Diseases
- Brain Metastases and Treatment
- Esophageal and GI Pathology
- Lung Cancer Research Studies
Tokyo Medical University
2016-2025
Rakuten (United States)
2024
Tokyo Medical University Hospital
2010-2023
Shinjuku Yamabuki High School
2023
University of the Ryukyus
2023
Kanazawa University
2023
University Medical Center
2023
Mita Hospital
2021
Nara Medical University
2021
The University of Texas MD Anderson Cancer Center
2020
PURPOSE This study aimed to compare patients with early oral cavity squamous cell carcinoma (OCSCC) (tumor category [T] 1-2, node-negative, and no distant metastasis) treated traditional elective neck dissection (ND) those managed by sentinel lymph node biopsy (SLNB) using survival function complications as end points. METHODS Sixteen institutions in Japan participated the (trial registration number: UMIN000006510). Patients of age ≥ 18 years histologically confirmed, previously untreated...
Salivary duct carcinoma (SDC) is an uncommon, aggressive malignant neoplasm histologically resembling high-grade mammary ductal carcinoma. SDC can arise de novo or ex pleomorphic adenoma. To clarify the correlation of biomarker immunoprofile with clinicopathological findings and clinical outcome SDC, we conducted immunohistochemistry for EGFR, HER2, HER3, AR, CK5/6, p53, Ki-67, along HER2 fluorescence in situ hybridization 151 SDCs. SDCs adenoma more commonly overexpressed Ki-67 than (P =...
Among salivary gland malignancies, the prognosis of duct carcinoma (SDC) is assumed to be poorest. However, because its low incidence, reliable survival estimates and prognostic factors based on a large number patients remain elucidated, thereby making it impossible standardize optimal treatment for SDC. We performed this multi-institutional, retrospective analysis by collecting clinical information 141 with SDC without distant metastasis who underwent curative surgery as initial elucidate...
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because its histologic variety, it sometimes challenging to make an accurate diagnosis, useful ancillary tests are essential for this purpose. We investigated 87 cases EMC arising in the major minor glands seromucinous nasal cavity or bronchus describe features mutation status selected key...
Background: No large-scale retrospective studies have examined the efficacy and safety of nivolumab.Objective: This study aimed to investigate nivolumab administered patients in multiple facilities.Material methods: The primary endpoint was overall response rate (ORR) secondary endpoints were progression-free survival (PFS) (OS). For safety, adverse event occurrence rates by grade, deaths severe events investigated. OS PFS also according whether immune-related (irAEs) appeared. Statistical...
Abstract Background To fill the data gap between clinical trials and real-world settings, this study assessed overall effectiveness safety of nivolumab in patients with head neck cancer (HNC) during Japanese practice. Methods This was a multicenter, retrospective recurrent or metastatic HNC who received for first time July December 2017. Data on use, effectiveness, were extracted from patient medical records. Results Overall, 256 enrolled study. The median duration treatment 72.5 days,...
Anaplastic thyroid cancer (ATC) is a rare and extremely aggressive malignancy, with median survival of less than 6 months due to rapid progression resistance multimodal therapies. Effective treatment strategies have not been identified. A prospective clinical study was performed objectively evaluate outcomes paclitaxel.An investigator-initiated, multicenter, nonrandomized, open-label, single-arm the feasibility efficacy weekly paclitaxel (80 mg/m(2)) administration for patients...
Abstract Although immune-checkpoint inhibitors (ICIs) are effective against various cancers, little is known regarding their role in salivary gland carcinoma (SGC) treatment. Therefore, we evaluated the efficacy and safety of nivolumab monotherapy patients with recurrent and/or metastatic SGC. In this multicentre retrospective study, (240 mg) was administered every 2 weeks. The overall response rate (ORR), progression-free survival (PFS), (OS), were examined; correlation between treatment...
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland cancer characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because its histologic variety overlap features with other tumors, there are broad differential diagnoses. The HRAS Q61R mutation has been reported to be frequent in specific EMC. We evaluated the usefulness RAS mutant-specific immunohistochemical (IHC) staining for detecting this genetic alteration investigated 83...
The efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted therapy androgen deprivation (ADT) for locally advanced or recurrent metastatic (LA/RM) salivary duct carcinoma (SDC) have been reported in prospective studies. However, the survival benefit these therapies to conventional remains controversial, whether HER2-targeted ADT should be chosen HER2- (AR)-positive SDC patients unknown.
Nivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, limited rates long-term survivors (< 20%) demand robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify plasma exosome (PEX) mRNA signature, which serves as companion diagnostic nivolumab provides biological clue develop effective therapies for majority non-survivors. Pre-treatment plasmas (N = 104)...
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) is a hypersensitivity disorder characterized by asthma, nasal polyposis, and NSAID intolerance. Eosinophilic chronic rhinosinusitis (ECRS) coexists with N-ERD in approximately 7.4% of cases. As sodium succinate corticosteroids (SSC) may exacerbate symptoms patients N-ERD, phosphate (SPC) are generally recommended as an alternative. This report presents case which SPC additives possibly triggered attack during...
Type IV thyroplasty (TP IV) is commonly regarded as a simple surgical procedure to raise the pitch of speaking fundamental frequency (SFF) by lengthening vocal folds through approximation thyroid and cricoid cartilages. However, we report two cases in which TP was unsuccessful due excessive shortening cricothyroid distance analyzed three-dimensional computed tomography (3D CT). One case performed under general anesthesia other local anesthesia. In normal high-pitched phonation, rotational...
To develop and evaluate the voice outcomes of an approach arytenoid adduction (AA) through a fenestration thyroid ala for unilateral vocal cord paralysis.Twelve consecutive patients with severe paralysis, whose maximum phonation times (MPTs) were less than or equal to 5 seconds, underwent laryngoplasty using AA performed combined type I thyroplasty.Two surgical windows made in lower part ala. The anterior window was typical thyroplasty, posterior AA. by pulling lateral cricoarytenoid muscle...
The molecular characteristics of therapeutically-relevant targets and their clinicopathological implications in salivary duct carcinomas (SDCs) are poorly understood. We investigated the gene alterations immunoexpression crucial oncogenic molecules 151 SDCs. mutation rates that were identified, order frequency, as follows: TP53, 68%; PIK3CA, 18%; H-RAS, 16%; BRAF, 4%; AKT1, 1.5%. PIK3CA/H-RAS/BRAF mutations more common de novo SDC than ex-pleomorphic adenoma. Furthermore, these mutually...
Abstract Background There is increasing evidence that immunotherapy with nivolumab, an anti‐programmed death 1 monoclonal antibody, effective in the treatment of recurrent or metastatic squamous cell carcinoma head and neck (R/M SCCHN). However, predictive role hematological inflammatory markers such as neutrophil‐to‐lymphocyte ratio (NLR) modified Glasgow prognostic score (mGPS) patients R/M SCCHN treated nivolumab remains unclear. Methods We conducted a multi‐institutional cohort study to...
Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) epidermal growth factor receptor (EGFR) knock-out A549 non-BCR-ABL-expressing leukemia cell lines, respectively. This evidence suggests TKI-induced is independent the original target molecules. The present study compared autophagy-inducing abilities various TKIs, regardless their targets, by quantitative flux assay. established stable clones...
Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of solid tumor component in AdCC specimens is an important index. However, "solid component" has not been well defined. Salivary cases (N = 195) were collected after a central pathology review. We introduced novel criterion component, minAmax (minor axis maximum). The largest nest each case was histologically...
Background/Aim: Head and neck photoimmuno-therapy (HN-PIT) has been an insured treatment in Japan for approximately three years. The number of treatments gradually increased to over 350 cases. However, there are still various questions actual clinical practice, including laryngeal edema. Therefore, it is vital carefully explain advance patients the possibility edema occurring obtaining consent tracheostomy as a prophylactic or emergency measure. At our institution, 44 HN-PIT cycles were...