A5102979841- Head and Neck Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Neural dynamics and brain function
- Cerebrospinal fluid and hydrocephalus
- Cancer-related Molecular Pathways
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Liquid Crystal Research Advancements
- Traumatic Brain Injury and Neurovascular Disturbances
- Otolaryngology and Infectious Diseases
- Streptococcal Infections and Treatments
- Noise Effects and Management
- Cassava research and cyanide
- Salivary Gland Tumors Diagnosis and Treatment
- Electron Spin Resonance Studies
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Advanced Neuroimaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
Tokyo City University
2012-2024
Showa General Hospital
2021-2023
The University of Tokyo
2013-2023
University of Tokyo Hospital
2018-2023
Doshisha University
2022
Gunma University
2018
The Cancer Institute Hospital
2006-2017
Hokkaido University
2016-2017
Japanese Foundation For Cancer Research
2007-2017
Teikyo University
2017
Abstract Background To fill the data gap between clinical trials and real-world settings, this study assessed overall effectiveness safety of nivolumab in patients with head neck cancer (HNC) during Japanese practice. Methods This was a multicenter, retrospective recurrent or metastatic HNC who received for first time July December 2017. Data on use, effectiveness, were extracted from patient medical records. Results Overall, 256 enrolled study. The median duration treatment 72.5 days,...
In head and neck cancer, early detection of recurrence after treatment is important. The contemporary development therapeutic agents have improved the prognosis recurrence; however, no biomarker has been established for evaluating effects or detecting recurrence. Recently, circulating tumor DNA (ctDNA), which comprises derived from cells exists in form cell-free blood, attracted attention as a minimally invasive repeatable cancer. We validated usefulness ctDNA human papilloma virus...
BACKGROUND The prevalence and prognostic value of human papillomavirus‐related oropharyngeal squamous cell carcinoma (OPSCC) in Japan has not been evaluated. METHODS Over a 12‐year period, the authors used immunohistochemistry to evaluate expression p16 (a cyclin‐dependent kinase inhibitor tumor suppressor) samples from 173 patients with OPSCC at single institution determine its influence on disease prognosis. RESULTS p16‐positive was 33.7% tonsillar carcinoma, 28.6% tongue base 0% posterior...
In a previous study, we reported the value of p16 expression and alcohol consumption in oropharyngeal carcinoma Japan. We now report clinical significance human papillomavirus status Over 9-year period, retrospective case comparison study pathology database was conducted at University Tokyo to identify tumor samples carcinoma. performed immunohistochemistry for protein, situ hybridization papillomavirus-deoxyribonucleic acid polymerase chain reaction oncogene E6 Japanese patients. evaluated...
Background Although the American Joint Committee on Cancer TNM classification has been amended to include human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) as an independent entity, authors' knowledge optimized de‐escalating treatment modality not established date. Methods The authors conducted a retrospective, nationwide, observational study in patients with HPV‐related OPSCC who were treated from 2011 2014 Japan determine best modality. Results A total of 688...
A 68 year old Japanese female with unilateral metamorphopsia of the face that developed after a small haemorrhage in contralateral retrosplenial region, is described. The patient claimed right side face, is, left when looked at by patient, appeared smaller than left. In addition, her drawings showed some distortions. Objects other were perceived normally. Cranial CT scan revealed high density area region. appears to have special representation posterior hemisphere.
To elucidate the optimal cutoff and accuracy of duplex ultrasonography (DUS) parameters for in-stent restenosis (ISR) after nitinol stenting in superficial femoral artery (SFA).Few data are available regarding performance DUS binary ISR based on quantitative vessel analysis (QVA) era SFA stenting.This retrospective study included 74 stenoses who underwent before follow-up angiography. parameters, such as peak systolic velocity (PSV) ratio (PSVR), were compared with percent diameter stenosis...
Abstract The purpose of this study was to investigate an association between the prognosis for oro-hypopharynx squamous cell carcinoma treated with radiation therapy and pre-therapeutic level C-reactive protein (CRP). Patient oro-hypopharyngeal who underwent definitive radiotherapy in our institution from January 2002 August 2016 were enrolled. patient divided into elevated CRP (over 0.3 mg/dl) group normal groups, according pre-treatment serum levels. There 276 evaluable patients, median...
TP53 is the most frequently mutated gene in human cancers. Previous studies reported that mutations correlated with poor prognoses patients head and neck squamous cell carcinoma (HNSCC). However, relationship between hypopharyngeal (HPSCC) not known. The current study aimed to evaluate mutation status as a predictive biomarker HPSCC. We retrospectively reviewed clinical charts of 57 HPSCC treated initial surgery 2008 2014. was determined by Sanger sequencing, were classified into wild-type,...
Sixty-one children with pineal region tumours were managed at the Hospital for Sick Children during period 1950-1982. Histologic verification of these was possible in forty-six children. Although germ cell commonest form, germinomas only made up one third tumours. Since 1967, an aggressive approach has been adopted management thirty-four patients having direct surgery on their mass out a total forty-one such The operative mortality tumour steadily fallen so that between 1975 and 1982 4.3%...
Background:Although telmisartan may be more beneficial for glucose metabolism than other angiotensin II receptor blockers (ARBs), it has not been determined whether exerts favorable effects on biological and functional parameters related to endothelial function ARBs.
We sought to evaluate clinical outcomes and toxicities of radiation therapy (RT) alone compared RT with concurrent chemotherapy (CCT) for nasopharyngeal carcinoma (NPC) treatment. conducted a retrospective review consecutive patients biopsy-proven nonmetastatic NPC who underwent at our institution. From May 2001 April 2015; 62 newly diagnosed were treated three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated (IMRT) without CCT. The classified as follows: 8% stage I, 15%...
The importance of TERT promoter (pTERT) mutation oral cavity squamous cell carcinoma (OCSCC) with clinical features and genetic alterations are not well recognized.We retrospectively analyzed data from multiple databases, including 260 cases the C-CAT database, 407 MSK-MetTropism 40 OCSCC datasets in-house samples.From TP53 (66%), CDKN2A (51%), pTERT (29%) were most frequent mutations observed. more prevalent in (63%), younger individuals, women (46%), lower rates alcohol abuse smoking...
Using magnetic resonance imaging and digitized brain computed tomography, we evaluated 33 elderly patients with documented lacunar stroke divided them into three groups (nondemented, n = 15; borderline, 9; demented, 9) by neuropsychological assessments DSM III criteria. We the extent of white matter lesions degree atrophy specific anatomic structures, such as corpus callosum, using quantified volumes ventricles, subarachnoid spaces, parenchyma tomography. Our results show that both...
Objective Immune checkpoint inhibitors (ICI) have become widely used becuse of their effectiveness and relatively low rate severe adverse events. However, active treatment should be continued after discontinuation ICI as response rates are lower than that conventional cytotoxic chemotherapy. The purpose the present study was to determine efficacy discontinuation. Methods This a retrospective from hospital charts 99 consecutive cases treated with at our facility since 2017. Of these, 79...