A5027967276- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Tumors and Oncological Cases
- Neuroendocrine Tumor Research Advances
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Neuroblastoma Research and Treatments
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Vascular Tumors and Angiosarcomas
- Gastric Cancer Management and Outcomes
- Proteoglycans and glycosaminoglycans research
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Vascular Malformations and Hemangiomas
- Viral-associated cancers and disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
Shizuoka General Hospital
2020-2023
Fujita Health University Hospital
2023
Matsumoto Dental University
2023
Shizuoka Cancer Center
2010-2019
Aichi Medical University
2007
Japanese Red Cross Medical Center
1993-2006
Kansai Medical University
2004-2006
Otsuka (Japan)
2004
Tokyo Medical and Dental University
1991
Large cell neuroendocrine carcinoma (LCNEC) is well-known as a lung cancer subtype. This study assessed the prevalence of head and neck mucosal LCNEC (M-LCNEC).M-LCNEC was studied clinically, histologically immunohistochemically.Of 814 surgically resected cases carcinoma, only eight (0.98%; all men, mean age 64.6 years) were rediagnosed M-LCNEC. They occurred in oropharynx (n=3), larynx (n=4) hypopharynx (n=1). Seven had regional lymph node metastases four resulted death. Histologically,...
Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of solid tumor component in AdCC specimens is an important index. However, "solid component" has not been well defined. Salivary cases (N = 195) were collected after a central pathology review. We introduced novel criterion component, minAmax (minor axis maximum). The largest nest each case was histologically...
Mucoepidermoid carcinoma (MEC) is rare, but the most common primary malignancy of salivary gland and not infrequent in young individuals. CRTC1/3-MAML2 fusions are frequently detected MEC useful as a diagnostic biomarker. However, there has been debate to whether have prognostic significance. In this study, we retrospectively collected 153 cases from 11 tertiary hospitals Japan. As inclusion criteria, patients study had curative surgery initial treatment, received no preoperative distant...
Abstract: Although pleomorphic adenoma is the most common type of salivary gland epithelial tumor, it frequently contains “mesenchymal”‐like components, including myxoid or chondroid tissues. We reported previously that tissue formation in was associated with overexpression bone morphogenetic proteins (BMPs) by neoplastic myoepithelial cells. BMPs belong to transforming growth factor (TGF)‐β superfamily, so we hypothesized may express TGF‐βs and these molecules regulate mesenchymal‐like...
We have previously demonstrated that stromal cells can support the proliferation and differentiation of hematopoietic in vitro vivo a major histocompatibility complex restriction exists between stem cells. also found intra–bone marrow (IBM) injection allogeneic bone (BMCs) leads to more rapid reconstitution than intravenous injection. In present study, we examine effect simultaneous BMCs into same on recovery donor demonstrate IBM plus is effective reconstituting recipients with or alone.
Objectives: To investigate the mechanisms underlying onset and progress of pancreatitis, 3 animal models (chronic, acute, severe pancreatitis) were established by double ligature pancreatic duct, injection with cerulein, or cerulein + duct. Methods: We prepared a control experimental groups: group 1 (untreated control), 2 (a chronic pancreatitis model; tail was exposed through midline incision, duct from this part double-ligated), (an acute intraperitoneally injected 7 times on day 0), 4...
Salivary duct carcinoma with rhabdoid features is extremely rare.We report 2 cases of salivary treated at our institution.Case 1 was a 44-year-old Japanese man who had swelling in the left parotid region. This tumor consisted residual pleomorphic adenoma and widely invasive carcinoma, which showed diffuse growth pattern by atypical cells. Case 66-year-old right cervical submandibular also composed both region adenocarcinoma components, whereas some metastatic lesions were purely Such cells...
Practical and reliable genotyping procedures with a considerable number of samples are required not only for risk-adapted therapeutic strategies, but also stratifying patients into future clinical trials molecular-targeting drugs. Recent advances in mutation testing, including next-generation sequencing, have led to the increased use formalin-fixed paraffin-embedded tissue. We evaluated gene alteration profiles cancer-related genes esophageal cancer correlated them clinicopathological...
Basic and acidic fibroblast growth factors (bFGF aFGF) are heparin-binding factors, promote fibrogenesis angiogenesis. We investigated the immunohistochemical localization of bFGFE, aFGF, FGF receptor-1 in pleomorphic adenomas. In normal salivary glands, bFGF was localized basement membranes intercalated ducts, acini basal cells excretory while aFGF focally ductal ducts. adenomas, immunolocalized around solid nests myoepithelial cells, neoplastic myxoid areas, lacuna chondroid areas....
Salivary pleomorphic adenomas are often associated with chondroid tissue formation. We have found that bone morphogenetic proteins (BMP), especially BMP-2, may play an important role in ectopic chondrogenesis this tumor. Bone protein-6 was reported to be related the osteogenic metastasis of prostatic carcinomas. The relationship between BMP-6 expression and formation is investigated. Twenty-three were examined immunohistochemically. overexpression observed 10 major salivary glands (43. 5%),...
Adenosquamous carcinoma ( ASC ) is a rare malignant neoplasm of the head and neck regions. We elucidated relationship between MUC molecule expression. selected 14 cases in neck, examined them immunohistohcmically. Seven tongue, 3 larynx 4 hypopharynx were selected. Nine (64.3%) showed lymph node metastasis at diagnosis. Laryngeal hypopharyngeal higher stage. Six (66.7%), all which metastases, died disease. Immunohistochemical examinations that was positive for both markers squamous cell...
Cancer/testis antigens (CTAs) are detected in cancer cells but not healthy normal tissues, with the exception of gametogenic tissues. CTAs highly immunogenic proteins, and thus represent ideal targets for cytotoxic T-lymphocyte-mediated specific immune therapy. The aim this study was to screen CTA expression various types salivary gland carcinoma clarify clinicopathological significance MAGE-A NY-ESO-1 adenoid cystic carcinomas (AdCCs) gland, which is one most common carcinomas, usually has...