A5101489153- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- interferon and immune responses
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Circular RNAs in diseases
- Cutaneous lymphoproliferative disorders research
- Endometrial and Cervical Cancer Treatments
- Aortic aneurysm repair treatments
- Ear and Head Tumors
- NF-κB Signaling Pathways
- Nail Diseases and Treatments
- Cancer survivorship and care
Yale Cancer Center
2020-2024
Yale New Haven Hospital
2015-2024
Yale University
2015-2024
Hebei Medical University
2024
Indiana University
2024
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2024
Fourth Hospital of Hebei Medical University
2024
Jiangxi Provincial Cancer Hospital
2024
Smilow Cancer Hospital
2016-2024
The University of Texas MD Anderson Cancer Center
2022-2024
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
The NCCN Guidelines for Prostate Cancer provide a framework on which to base decisions regarding the workup of patients with prostate cancer, risk stratification and management localized disease, post-treatment monitoring, treatment recurrence advanced disease. sections included in this article focus metastatic castration-sensitive nonmetastatic castration-resistant cancer (CRPC), CRPC (mCRPC). Androgen deprivation therapy (ADT) intensification is strongly recommended cancer. For CRPC, ADT...
The NCCN Guidelines for Prostate Cancer address staging and risk assessment after a prostate cancer diagnosis include management options localized, regional, recurrent, metastatic disease. Panel meets annually to reevaluate update their recommendations based on new clinical data input from within Member Institutions external entities. These Insights summarizes much of the panel's discussions 4.2022 1.2023 updates guidelines regarding systemic therapy cancer.
The NCCN Guidelines for Prostate Cancer include recommendations staging and risk assessment after a prostate cancer diagnosis the care of patients with localized, regional, recurrent, metastatic disease. These Insights summarize panel's discussions 2024 update to guidelines regard initial stratification, management very-low-risk disease, treatment nonmetastatic recurrence.
Restoration of dysfunctional tumor vasculature can reestablish the pressure gradient between intravascular and interstitial space that is essential for transporting nanomedicines into solid tumors. Morphologic functional normalization vessels improves tissue perfusion to facilitate intratumoral nanoparticle delivery. However, this remodeling process also reduces vessel permeability, which impair transport. Although nanoparticles sized below 10 nm maximally benefited from therapy enhanced...
BACKGROUND Extranodal (or extracapsular) extension (ENE) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery. However, the significance of ENE human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) not well established, single‐institution studies have established that predicts inferior outcome. The authors investigated value HPV‐positive underwent surgery whether adjuvant chemoradiation improved overall survival (OS)...
303 Background: Six months of a GnRH agonist with SRT is standard care for patients unfavorable features and detectable PSA post-RP. FORMULA-509 was designed to evaluate whether adding six AAP Apa this regimen could improve outcomes. Methods: (NCT03141671) an investigator-initiated, multi-center, open-label, randomized trial. Patients had PSA≥0.1 post-RP one or more (Gleason 8-10, PSA>0.5, pT3/T4, pN1 radiographic N1, doubling time <10 months, negative margins, persistent PSA, gross...
Alginate oligosaccharide (AOS) has recently demonstrated the ability to protect against acute doxorubicin cardiotoxicity and neurodegenerative disorders by inhibiting oxidative stress endoplasmic reticulum (ER) stress-mediated apoptosis, which are both involved in myocardial ischemia/reperfusion (I/R) injury. In present study, we investigated whether pretreatment with AOS protects I/R injury mice explored potential cardioprotective mechanisms. significantly decreased infarct size, reduced...
Abstract Purpose: Human papillomavirus–negative (HPV−) head and neck squamous cell carcinomas (HNSCC) harbor frequent genomic amplification of Fas-associated death domain, with or without concurrent Baculovirus inhibitor apoptosis repeat containing (BIRC2/3) genes encoding cellular proteins 1/2 (cIAP1/2). Antagonists targeting cIAP1 have been reported to enhance sensitivity HPV−, but not HPV+ tumors, TNF family ligands (TNF TRAIL) radiation. Experimental Design: We tested a novel dual...
Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, decreased locoregional control overall survival (OS). In the present analysis, we examine whether upfront surgical resection improves large national sample.To compare outcomes among patients newly diagnosed cT1-2 N1-2b HPV-negative OPSCC when treated...
<h3>Importance</h3> To date, the risk of developing second primary cancers (SPCs) after first melanoma has not been studied in era immune checkpoint inhibitors (ICIs). <h3>Objective</h3> assess differences SPCs patients with before (2005-2010) and (2011-2016) introduction approval ICIs. <h3>Design, Setting, Participants</h3> Population-based cohort study using Surveillance, Epidemiology, End Results database from January 2005 to December 2016 diagnosed metastatic melanoma. Data were analyzed...
Background Treatment at high‐volume surgical facilities (HVSFs) provides a survival benefit for patients with head and neck squamous cell carcinomas (HNSCCs); however, it is unknown what role postoperative radiation therapy (PORT) plays in achieving the improved outcomes. Methods From National Cancer Database, 6844 locally advanced invasive HNSCCs of oral cavity, oropharynx, larynx, hypopharynx who underwent definitive surgery PORT between 2004 2013 were identified. HVSFs those top...
Importance Although tissue-based gene expression testing has become widely used for prostate cancer risk stratification, its prognostic performance in the setting of clinical care is not well understood. Objective To develop a linkage between genomic classifier (GC) and data across payers sites US. Design, Setting, Participants In this cohort study, transcriptomic from use GC 2016 2022 were linked with aggregated insurance claims, pharmacy records, electronic health record (EHR) data....
Background and objectiveAlthough the prognostic significance of Decipher prostate cancer genomic classifier (GC) has been established largely from analyses archival tissue, less is known about associations between results testing oncologic outcomes among patients receiving contemporaneous treatment in real-world practice setting. Our objective was to assess GC risks metastasis biochemical recurrence (BCR) following biopsy radical prostatectomy (RP) tested treated setting.MethodsA...