A5101470379- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Acoustic Wave Resonator Technologies
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Mechanical and Optical Resonators
- Analytical Chemistry and Sensors
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Radiation Therapy and Dosimetry
- Global Cancer Incidence and Screening
- Prostate Cancer Treatment and Research
Levine Cancer Institute
2017-2024
Southeast Radiation Oncology Group
2017-2024
Atrium Medical Cente
2024
Carolinas Healthcare System
2019
Yale University
2013-2018
The University of Texas MD Anderson Cancer Center
2017
American University of Beirut
2016
Brigham and Women's Hospital
2015
Lynn University
2015
Yale Cancer Center
2014
2-Hydroxyglutarate (2HG) exists as two enantiomers, (R)-2HG and (S)-2HG, both are implicated in tumor progression via their inhibitory effects on α-ketoglutarate (αKG)-dependent dioxygenases. The former is an oncometabolite that induced by the neomorphic activity conferred isocitrate dehydrogenase 1 (IDH1) IDH2 mutations, whereas latter produced under pathologic processes such hypoxia. We report IDH1/2 mutations induce a homologous recombination (HR) defect renders cells exquisitely...
Purpose To review trends in the use of postoperative radiotherapy (PORT) for stage II and III incompletely resected non–small-cell lung cancer (NSCLC) evaluate association between PORT survival such patients. Patients Methods We identified patients with pathologic N0-2, overall American Joint Committee on Cancer or NSCLC within National Data Base who had undergone a lobectomy pneumonectomy positive surgical margins. Only coded as receiving external-beam at 50 to 74 Gy observation were...
OBJECT Single-fraction stereotactic radiosurgery (SRS) is a crucial component in the management of limited brain metastases from non-small cell lung cancer (NSCLC). Intracranial SRS has traditionally been delivered using frame-based Gamma Knife (GK) platform, but modifications to linear accelerator (LINAC) have made an alternative approach possible. In absence definitive prospective trials comparing efficacy and toxicities treatment between 2 techniques, nonclinical factors (such as...
BACKGROUND The optimal treatment for resected pancreatic cancer is controversial because direct comparisons of adjuvant chemotherapy (CT) alone and radiotherapy (CRT) are limited. This study assessed outcomes CT versus CRT in a national cohort to provide modern estimate comparative effectiveness. METHODS Patients with pT1‐3N0‐1M0 adenocarcinoma after pancreatectomy were identified the National Cancer Data Base. Overall survival (OS) was compared groups Cox regression propensity score...
Stereotactic body radiation therapy (SBRT) has become increasingly utilized over the last decade in treatment of inoperable stage I non-small cell lung cancer (NSCLC) patients, although no standardized dosing guidelines exist. In this retrospective study, we investigated dose prescription pattern use United States for patients receiving SBRT.Patients with NSCLC treated SBRT between 2004 and 2011 were identified within National Cancer Database (NCDB). Trends prescriptions analyzed.A total...
To investigate outcomes for elderly patients treated with chemotherapy (CT) alone versus chemoradiotherapy (CRT) in the modern era by using a large national database.Elderly (age ≥ 70 years) limited-stage small-cell lung cancer clinical stage I to III who received CT or CRT were identified National Cancer Data Base between 2003 and 2011. Hierarchical mixed-effects logistic regression clustering reporting facility was performed identify factors associated treatment selection. Overall survival...
In recent years, interest in the development of highly sensitive acoustic wave devices as biosensor platforms has grown. A considerable amount research been conducted on AT-cut quartz resonators both thickness excitation and lateral configurations. this report, we demonstrate fabrication a ZnO solidly mounted resonator operated shear mode (TSM) using field piezoelectric film. Theoretical Christoffel equation calculations are provided to explore conditions for TSM c-axis-oriented through...
The current American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system, developed human papillomavirus (HPV)-unrelated disease, discriminates poorly when applied to HPV-related oropharyngeal squamous cell cancer (OPSCC), leading calls a new system.To compare the prognostic ability of AJCC/UICC seventh edition system; recently proposed Collaboration Oropharyngeal Network Staging (ICON-S); and novel objectively derived system OPSCC using national...
Elderly patients with early-stage breast cancer (ESBC) derive a local control benefit from radiotherapy (RT) after lumpectomy, without any apparent effect on overall survival. Therefore, the use of RT is controversial. In current study, authors characterized updated trends in for elderly estrogen receptor (ER)-positive ESBC.Patients aged ≥70 years ER-positive ESBC measuring ≤2 cm lumpectomy negative resection margins and known details were identified National Cancer Data Base. Patients...