A5068839347- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Adolescent and Pediatric Healthcare
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Surgical Simulation and Training
- Viral-associated cancers and disorders
- Folate and B Vitamins Research
- MRI in cancer diagnosis
- Anatomy and Medical Technology
- Testicular diseases and treatments
- Renal Diseases and Glomerulopathies
- Prenatal Screening and Diagnostics
- Urinary Bladder and Prostate Research
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Birth, Development, and Health
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Minimally Invasive Surgical Techniques
- Digital Radiography and Breast Imaging
- Multiple and Secondary Primary Cancers
- CCD and CMOS Imaging Sensors
Yokohama City University
2012-2025
Yokohama City University Hospital
2025
Yokosuka Kyosai Hospital
2022-2024
Mitsui (Japan)
2024
Yale University
2018-2023
University of California, Los Angeles
2019-2023
Ronald Reagan UCLA Medical Center
2019-2020
Japanese Red Cross Fukuoka Hospital
2019
Kyushu University
2008-2019
First Affiliated Hospital of GuangXi Medical University
2019
Abstract Fumarate accumulation due to loss of fumarate hydratase (FH) drives cellular transformation. Germline FH alterations lead hereditary leiomyomatosis and renal cell cancer (HLRCC) where patients are predisposed an aggressive form kidney cancer. There is unmet need classify variants by cancer-associated risk. We quantified catalytic efficiencies 74 uncertain significance. Over half were enzymatically inactive, which strong evidence pathogenicity. next generated a panel HLRCC lines...
Abstract Background We reported previously that 18 F-2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography (FDG PET/CT) had potential for evaluating early response to treatment by tyrosine kinase inhibitors (TKIs) in advanced renal cell carcinoma (RCC). This time we investigated the relation of assessment FDG PET/CT long-term prognosis with an expanded number patients and period observation. Methods Patients whom TKI RCC was planned were enrolled. performed before after...
Various molecular-targeting therapies have become available for the treatment of advanced renal cell carcinoma (RCC). Accurate prognostication is desirable choosing appropriate individual patients. 18F-2-fluoro-2-deoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) a non-invasive tool evaluating glucose accumulation, which can be an index biological characteristics cancer. We prospectively evaluated FDG PET/CT as prognostic indicator in patients with RCC. A total 101...
Lower urinary tract symptoms (LUTS) significantly affect patient quality of life. Treatment options for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) (a common cause LUTS) are insufficient relieve discomfort. As the incidence BPH is increasing, new pharmacological targets LUTS treatment required. Corticotropin-releasing hormone (CRH) a neuropeptide that controls normal micturition in rodents. Herein, we investigated role spinal CRH regulating sham and BOO rats,...
<title>Abstract</title> The significance of “L” score in the radius (R), exophytic/endophytic (E), nearness (N), anterior/posterior (A), location (L); RENAL nephrometry scoring system remains unestablished compared to other subscores. This study assessed influence on surgical and functional outcomes RAPN, dividing renal tumors into medial lateral relative kidney's central line, explore its impact utility. A retrospective analysis was conducted 668 RAPN patients, with 405 having 263 tumors....
Tyrosine kinase inhibitors (TKIs) have become the mainstay of treatment for advanced renal cell carcinoma (RCC), but it has been unclear whether antitumor effect TKIs depends on organ where RCC metastasis is located. We previously reported that FDG accumulation assessed by PET/CT, was a powerful index evaluating biological response to TKI. In this study we investigated differences in and TKI as PET/CT among various organs were A total 48 patients with treated (25 sunitinib 23 sorafenib)...
Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand mechanism by which RCC acquires resistance TKI, we investigated change glucose accumulation in FDG PET/CT when they demonstrated progression disease (PD) against TKI. We monitored 38 treated TKI 162 sequentially until were judged demonstrate PD. Standardized uptake value (SUV), a simplified index tissue rate,...
Molecular chaperone heat shock protein 90 (HSP90) is involved in oncogenic signaling pathways including epithelial-mesenchymal transition (EMT), a key process tumor initiation, progression, metastasis, and chemoresistance. The molecular mechanisms underlying the involvement of HSP90 EMT are still under investigation. In this study, we identified previously unrecognized role cooperating with signal transducer activator transcription 3 (STAT3) to regulate TWIST1 cancer cells. inhibitor...
Objectives To describe and to validate a novel patient‐specific virtual‐reality based simulator for laparoscopic surgery. Methods Three surgeons carried out 13 preoperative simulations at Yokohama City University Hospital, Yokohama, Kanagawa, Japan, from 2011 2012. The procedures included seven nephrectomies, four partial nephrectomies two pyeloplasties. We evaluated whether the anatomies reproduced by matched those encountered during actual operations. Furthermore, were asked use visual...
Our understanding of how each hereditary kidney cancer adapts to its tissue microenvironment is incomplete. Here, we present single-cell transcriptomes 108,342 cells from patient specimens including six cancers. The displayed distinct characteristics the cell origin and unique for cancer. Of note, leiomyomatosis renal carcinoma (HLRCC)-associated retained some proximal tubules, which were completely lost in lymph node metastases as an avascular tumor with suppressed T TREM2-high macrophages,...
// Daiki Ueno 1 , * Juan C. Vasquez 2 Amrita Sule 3 Jiayu Liang 4 Jinny van Doorn Ranjini Sundaram Sam Friedman Randy Caliliw Shinji Ohtake Xun Bao 5 Jing Li Huihui Ye 6 Karla Boyd Rong Huang Jack Dodson 7 Paul Boutros Ranjit S. Bindra # and Brian Shuch Department of Urology, David Geffen School Medicine at UCLA, Los Angeles, CA 90095, USA Section Pediatric Hematology Oncology, Pediatrics, Yale University Medicine, New Haven, CT 06510, Therapeutic Radiology, West China Hospital/School...
Purpose: Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal carcinoma (ccRCC). The extent of small tumors remains unknown. Therefore, we set out evaluate resected large and tumors.Experimental Design: We conducted study from 2013 2016 that evaluated 47 consecutive ccRCC during radical or partial nephrectomy. Cases were designated as (<4 cm) (>7 tumors. Each tumor had three regions sampled. Copy-number variation (CNV) was...
The purpose of this study is presenting a method to predict the presence an open urinary tract and position opening in laparoscopic partial nephrectomy from three dimensional (3D) computed tomography (CT) images by using novel image segmentation visualization techniques. From CT patients who underwent nephrectomy, 3D regions kidney, tract, tumor were segmented. For each patient, multiple virtual resection planes kidney with different surgical margins (1 mm 5 mm, every 1 mm) generated...
Purpose: When working on fluoroscopy and patient assistance in a healthcare facility, workers need to understand how properly protect scattered radiation. In this study, we examined four-dimensional visualization method make it easy the spread of radiation visually, proposed its application protection education. Methods: We constructed X-ray room, CT angiography room using Particle Heavy Ion Transport code System (PHITS), calculated distribution when was irradiated with X-rays. The...
Abstract High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. New evidence supports a hypothesis that HGSOC can originate from fallopian tube epithelium (FTE). It unclear how genetic alterations and pathophysiological processes drive progression of FTE tumor precursors into widespread HGSOCs. In this study, we uncovered brain-derived neurotrophic factor (BDNF) in follicular fluid stimulates tropomyosin receptor kinase B (TrkB)-expressing cells to promote...
Abstract The tricarboxylic citric acid cycle enzyme fumarate hydratase (FH) is a tumor suppressor. When lost in cells, its substrate accumulates to mM levels and drives oncogenic signaling transformation. Germline alterations lead an autosomal dominant condition known as hereditary leiomyomatosis renal cell cancer (HLRCC) where patients are predisposed various benign tumors aggressive form of kidney cancer. FH unclear significance frequently observed with germline testing; thus, there unmet...