A5003502093- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Bone health and treatments
- Adrenal and Paraganglionic Tumors
- Radiopharmaceutical Chemistry and Applications
- Pediatric Urology and Nephrology Studies
- Cancer Immunotherapy and Biomarkers
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Nutrition and Health in Aging
- Renal and Vascular Pathologies
- Renal Transplantation Outcomes and Treatments
- Sperm and Testicular Function
- Multiple and Secondary Primary Cancers
Yokohama City University Medical Center
2015-2025
Yokohama City University
2015-2025
Metabolism and Renal Physiology
2017
National Hospital Organization Hokkaido Medical Center
2011
Hokkaido University
1995-2005
Medical Center Hospital
2003
Kanagawa Rehabilitation Hospital
2000
Bladder cancers have been characterized as a tumor group in which the immunological response is relatively well preserved. Programmed death ligand 1 (PD-L1, B7-H1, CD274) has shown to be expressed several malignancies, including bladder cancer. However, clinicopathological impact of this biomarker not yet established. In present study, quantitative real-time polymerase chain reaction (qPCR) was performed using paired normal and cancerous cancer tissue investigate PD-1/PD-L1 gene expression....
Recently, sarcopenia has been reported as a new predictor for patient outcomes or likelihood of post-operative complications. The purpose this study was to evaluate the association psoas muscle volume with length hospitalization among patients undergoing radical cystectomy.A total 63 (80.8%) male and 15 (19.2%) female who underwent cystectomy their bladder cancer in our institution from 2000 2015 were analyzed. index (PMI) calculated by normalizing area using axial computed tomography at...
ABSTRACT Background Surgical treatment of a neuroblastoma, malignant tumor the sympathetic nervous system, may result in ejaculatory disorder. There are no reports examining ejaculation disorders after neuroblastoma surgery. Case Presentation The patient was 31‐year‐old Japanese male who had undergone surgery for abdomen at age 0. He difficulty ejaculation, with postorgasmic urinalysis showing sperm. A diagnosis anejaculation then established, and sperm retrieval via testicular extraction...
The aim of this study was to perform a comprehensive evaluation the renin-angiotensin system (RAS) in prostate cancer.We investigated expression RAS components cancer cells treated with hormonal agents. Real-time PCR data showed AT1 receptor, angiotensin I converting enzyme (ACE), and I/II (Ang-I/II) precursor all 87 tissue samples.Expression these genes hormone refractory (HRPC) significantly higher than that normal untreated tissue. Western blot protein receptor Ang-I/II enhanced LNCaP...
Introduction . Gemcitabine and cisplatin (GC) is a gold-standard first-line systemic chemotherapy for advanced urothelial carcinoma (UC). However, it may cause severe adverse effects such as renal toxicity, gastrointestinal neurotoxicity. Sarcopenia the age-related loss of skeletal muscle mass. A correlation between sarcopenia oncological prognosis has been reported. In UC, several studies have noted that patients with had greater incidence complications worse survival after radical...
Introduction and Objectives . An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an NLR as biomarker predict metastatic castration-resistant prostate cancer (mCRPC) patients treated cabazitaxel (CBZ). Methods analyzed 47 who received CBZ chemotherapy for mCRPC our institutions. The was calculated using neutrophil lymphocyte counts before chemotherapy. determined cut-off value based on...
The bone scan index (BSI), which is obtained using a computer-aided evaluation system, anticipated to become an objective and quantitative clinical tool for evaluating metastases in prostate cancer. Here, we assessed the usefulness of BSI as prognostic factor patients with metastatic castration-resistant cancer (mCRPC) treated docetaxel. We analyzed 41 who received docetaxel mCRPC. Bonenavi system was used calculation program BSI. utility predictor overall survival (OS) after evaluated. Cox...
The bone scan index (BSI) using a computer-aided diagnosis system for scans is expected to be an objective and quantitative clinical tool evaluating metastatic prostate cancer. This study aimed evaluate the pretreatment BSI as prognostic factor in hormone-naive cancer patients with metastases. included 60 hormone-naive, that was initially treated combined androgen blockade therapy. BONENAVI used calculating BSI. We evaluated correlation between overall survival (OS) clinicopathological...
Background: Enfortumab vedotin shows promise as a targeted therapy for advanced urothelial carcinoma, particularly in patients who have previously received platinum-based chemotherapy and an immune-checkpoint inhibitor. The EV-301 phase III trial demonstrated significantly improved overall survival response rates compared to standard chemotherapy. However, more data, especially from larger real-world studies, are needed further assess its effectiveness Japanese patients. Methods: A total of...
Paraganglioma is an extra site of pheochromocytoma. in the bladder a very rare disease accounting for 0.06% all tumors.A 77-year-old Japanese man was referred to our department further examination tumor detected on preoperative computed tomography his gastric cancer. Cystoscopy revealed submucosal upper area bladder, so transurethral resection performed. During tumor, blood pressure sharply increased, and pathological showed paraganglioma bladder. Postoperative I-123-metaiodobenzylguanidine...
We reported previously the usefulness of 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict prognosis renal cell carcinoma (RCC) treated with molecular targeted agents. Herein we describe a preliminary research nine patients who underwent FDG-PET/CT before and after initiation nivolumab. Patients metastatic RCC were by nivolumab from October 2016 March 2017 enrolled in this study. All at baseline 1 month as first response assessment,...
Abstract BACKGROUND The aim of this study was to perform a comprehensive evaluation angiotensin III (Ang‐III) and related converting enzymes, aminopeptidase A (APA) N (APN), in prostate cancer. METHODS We investigated the effects Ang‐III on vitro growth human cancer cells expression APA APN treated with or hormonal agents. Furthermore, we performed real‐time quantitative PCR investigate pattern 86 tissue samples including normal prostate, untreated hormone refractory (HRPC). RESULTS...
Abstract BACKGROUND Although the local renin‐angiotensin system (RAS) of prostate gland is related to cell proliferation and angiogenesis, detailed mechanism remains unclear. We examined effects angiotensin II type 1 receptor (AT1R) on androgen (AR) expression in cancer cells. METHODS AR modulation by AT1R was Western blot analysis, luciferase assay, Immunocytochemical staining. The influence (Ang‐II) inhibition using siRNA determined. Furthermore, angiotensinogen or knockout (KO) mice, we...
Purpose For patients with metastatic castration-resistant prostatic cancer (mCRPC), docetaxel plus prednisone leads to superior survival and a higher response rate compared mitoxantrone prednisone. We analyzed the efficacy of long-term treatment ≥10 cycles docetaxel, validated risk group classification in predicting overall (OS) Japanese mCRPC. Patients Methods Fifty-two mCRPC were administered 55 mg/m2 8 mg dexamethasone, every 3 or 4 weeks, simultaneously hormonal therapy daily oral...
The neutrophil-to-lymphocyte ratio (NLR) is reported as a biomarker for some solid malignant diseases. Thus far, however, no reports of the relationship between NLR and adrenal tumors have been published. We analyzed utility preoperative predicting prognosis or diagnosis disease.A total 59 patients with (13 cases disease 46 benign disease) were in this study from February 2004 to June 2015 at our institute. was obtained just before adrenalectomy. tumor confirmed by pathological examination...
<i>Objective:</i> We assessed the roles of suprapubic cystostomy in patients with neurogenic bladder and analyzed complications their courses. <i>Patients Methods:</i> reviewed 118 managed cystostomy. The original diseases were spinal cord injury 90, degenerative disease central nervous system 15, spina bifida 6, cerebral palsy 3, pontine bleeding 1, Parkinson’s brain tumor dysgenesis external sphincter 1. Fifty-six (62.2%) cord-injured demonstrated cervical damage....
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce expression of NSAID-activated gene 1 (NAG-1). NAG-1 in prostate cancer has previously been detected by microarray and immunohistochemical analyses. We examined the mRNA quantitative real-time polymerase chain reaction using 51 human tissue specimens. The level was higher than normal tissues (p = 0.025). also significantly well-differentiated moderately 0.04) poorly differentiated adenocarcinomas 0.03). These data suggest that may be a new...
Foreign bodies are occasionally reported in the bladder. In most cases, foreign body is removed via transurethral approach. A 57-year-old male patient was referred to our hospital undergo retrieval of a from his However, had become severely calcified and could not be transurethrally. Thus, an open bladder wall incision necessary remove it. We herein report case that which successfully using higher careful preoperative examination should performed detect characteristics avoid risk perforation.
Most patients with testicular cancer are infertile; thus, the preservation of sperm after surgery is an important factor to consider. We report two cases bilateral in who underwent higher orchiectomy and simultaneous extraction.Two Asian-Japanese men were referred our hospital tumors. Both preoperatively diagnosed azoospermia requested extraction at time orchiectomy. In one patient, was successfully harvested then frozen. other could not be retrieved from patient's testis. both patients,...
Birt-Hogg-Dubé (BHD) syndrome is a hereditary kidney cancer syndrome, which predisposes patients to develop cancer, cutaneous fibrofolliculomas and pulmonary cysts. The responsible gene FLCN tumor suppressor for plays an important role in energy homeostasis through the regulation of mitochondrial oxidative metabolism. However, process by FLCN-deficiency leads renal tumorigenesis unclear. In order clarify molecular pathogenesis BHD-associated we conducted whole-exome sequencing analysis using...
Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological disease, but the treatment policy is unclear. The present study examined risk factors for predicting stent failure in patients with MUO after insertion and change renal function retrograde cases of bilateral hydronephrosis.A total 39 who required placement at Yokohama City University Medical Center (Yokohama, Japan) between February 2007 May 2016 were included this study. age,...