A5066297986- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Pancreatic function and diabetes
- Urological Disorders and Treatments
- Renal and related cancers
- Kidney Stones and Urolithiasis Treatments
- Biomedical Research and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Infectious Disease Case Reports and Treatments
- Multiple and Secondary Primary Cancers
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Renal Diseases and Glomerulopathies
- Prostate Cancer Treatment and Research
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Ion Transport and Channel Regulation
- Skin Diseases and Diabetes
Yokohama City University
2015-2024
Yokohama Minami Kyosai Hospital
2023
Yokosuka Kyosai Hospital
2017-2019
Our understanding of how each hereditary kidney cancer adapts to its tissue microenvironment is incomplete. Here, we present single-cell transcriptomes 108,342 cells from patient specimens including six cancers. The displayed distinct characteristics the cell origin and unique for cancer. Of note, leiomyomatosis renal carcinoma (HLRCC)-associated retained some proximal tubules, which were completely lost in lymph node metastases as an avascular tumor with suppressed T TREM2-high macrophages,...
Birt-Hogg-Dubé (BHD) syndrome, caused by germline alteration of folliculin (FLCN) gene, develops hybrid oncocytic/chromophobe tumour (HOCT) and chromophobe renal cell carcinoma (ChRCC), whereas sporadic ChRCC does not harbor FLCN alteration. To date, molecular characteristics these similar histological types tumours have been incompletely elucidated.
A 45-year-old man complained of a palpable mass in his left abdomen. Computed tomography showed horseshoe kidney with Bosniak type II complicated cyst from segment. Three years after initial examination, due to the growing cystic lesion and compression imposed on urinary collecting system surrounding organs, we performed heminephrectomy. The diagnosis was mucinous cystadenoma kidney. No recurrence observed 6 months surgery. histopathology unique since inner surface covered by mucin-positive...
Objective: More accurate diagnostic procedures for prostate cancer are needed to avoid unnecessary biopsy due the low specificity of prostate-specific antigen (PSA). Recent studies showed that percentage serum isoform [–2]proPSA (p2PSA) free PSA (%p2PSA), Prostate Health Index (PHI) and magnetic resonance imaging (MRI) were more than PSA. The aim this study was test accuracy %p2PSA, PHI MRI in discriminating patients with without cancer.Materials methods: subjects 50 consecutive men a level...
A 73-year-old woman was referred to our department with a complaint of asymptomatic gross hematuria. Dynamic computed tomography revealed complicated (Bosniak type IIF) cyst in the upper pole her right kidney, which diagnosed as calyceal diverticulum. The diagnosis confirmed by ureteroscopy. diverticulum filled soft protein matrix that difficult completely remove from inner surface Endoscopy combined intrarenal surgery (ECIRS) performed matrix. Percutaneous nephroscopy further papillary...
Key Clinical Message Renal lymphoma as an initial lesion is relatively rare. Bilateral renal frequently presents acute kidney injury. With systematic chemotherapy for the lymphoma, patients usually recover their function. However, in case we describe here, patient's function recovered greatly after open biopsy. Here, review and discuss this unique case.
<title>Abstract</title> A regulatory mechanism for SLC family transporters, critical transporters sodium and glucose reabsorptions in renal tubule, is incompletely understood. Here, we report an important regulation of transporter by <italic>SETD2</italic>, a chromatin remodeling gene whose alterations have been found subset kidney cancers. Kidney-specific inactivation <italic>Setd2</italic> resulted hypovolemia with excessive urine excretion mouse interestingly, RNA-sequencing analysis...
経尿道的結石破砕術(以下TUL)中に真菌球が確認された1例を報告する.患者は61歳男性,両側腎結石にて当科紹介.初回のTUL後に残石があったために再手術を行った.その際に腎盂で白色球体が無数に観察され,視野の確保が困難であった.3回目の手術時にも白色球体を多数認めた.培養検査を施行したところC.tropicalisが検出され,真菌球(以下fungus ball)と診断した.結石手術中にfungus ballを認めた報告例は調べ得た範囲では確認できなかった.
A 67-year-old female was hospitalized with back pain. Computed tomography (CT) incidentally revealed a tumor in her left kidney (33 mm) and bilateral breast tumors. She underwent biopsy diagnosed cancer (invasive lobular cancer, cT2N0M0). The renal suspected to be clear cell carcinoma, cT1aN0M0, based on contrast-enhanced CT. Surgery considered necessary for both the tumor. First, laparoscopic radical nephrectomy performed However, lateroconal fascia adhered strongly perirenal fat, so simple...
Mucinous cystic tumor of low malignant potential (MCTLMP) is a very rare disease.The patient was 50-year-old man. Contrast-enhanced computed tomography and magnetic resonance imaging showed multiocular lesion on the top bladder. We performed surgery to remove for definitive diagnosis. Intraoperative rapid pathological diagnosis cyst wall no findings, so we combined resection peritoneum part bladder wall.Based location, immunostaining findings (CK20 CDX2 positivity; β-catenin negativity),...
症例は82歳男性．下腹部痛と全身倦怠感を主訴に当科を受診した．腹部単純CTで前立腺肥大と80mm大の巨大な膀胱結石ならびに両側水腎水尿管症を認めた．血液検査所見では，炎症反応高値，高度の腎機能障害とそれによる高カリウム血症を認め，尿閉に伴う急性腎後性腎不全の診断となった．尿道カテーテル留置の上，緊急血液透析を施行し腎機能の改善を得た．巨大膀胱結石に対しては，単回の手術で結石を完全に摘除するために，経皮的・経尿道的内視鏡手術を併用し，結石は完全に除去された．排尿管理のため間欠的自己導尿を要したが，重篤な術後合併症もなく，患者は術後9日目に退院した．
非特異性肉芽腫性前立腺炎の一例を報告する．症例は58歳男性．発熱と排尿困難を主訴に近医を受診した．膿尿と前立腺の圧痛があり，急性前立腺炎の診断で抗菌薬により加療したが，症状の改善が乏しく当科紹介となった．直腸診では，石様硬・表面不整な前立腺を触れた．PSAは2.624ng/mlであった．MRIでは，不整に腫大した前立腺を認め，拡散強調像でびまん性に高信号を呈していた．検査所見より，前立腺癌を疑い前立腺針生検を施行した．しかし，非特異的な炎症細胞浸潤を認めるのみで，診断の確定に至らなかった．臨床所見としてなおも前立腺悪性腫瘍が強く疑われたため，経尿道的生検ならびに経直腸生検を追加施行した．病理組織学的検査の結果は，肉芽腫性前立腺炎であった．全身検索したが異常を認めず，アレルギー疾患・感染症も認めなかったため，非特異性肉芽腫性前立腺炎と考えられた．生検後3カ月経過観察し，MRIで前立腺不整腫大の著明な改善を認めた．非特異性肉芽腫性前立腺炎は稀な疾患で，臨床所見・画像所見からは前立腺癌と鑑別することは非常に困難であり，前立腺全摘出術を施行されている報告例もある．しかし，本症例のように予...
SUMMARY Our understanding of how each hereditary kidney cancer loses characteristics the originating nephron cells and adapts to its tissue microenvironment is incomplete. Here, we present single-cell transcriptomes 108,342 from specimens including six cancers, which displayed cell origin unique cancer. Of note, leiomyomatosis renal carcinoma (HLRCC)-associated retained some proximal tubules, were completely lost in lymph node metastases presents as an avascular tumor with exhausted T...