A5070712895- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Medical and Biological Ozone Research
- Biomarkers in Disease Mechanisms
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Effects of Radiation Exposure
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Extracellular vesicles in disease
- Complement system in diseases
- Intermetallics and Advanced Alloy Properties
- Graphene and Nanomaterials Applications
- Software Reliability and Analysis Research
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Advanced Welding Techniques Analysis
- Dietary Effects on Health
- Bacteriophages and microbial interactions
- Software Engineering Techniques and Practices
- Immunotherapy and Immune Responses
The University of Texas MD Anderson Cancer Center
2023-2025
Loyola Medicine
2024
All India Institute of Medical Sciences
2022-2023
Abstract The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery genetic cargo to cells and tissues remains challenging. Here, we show an adaptive strategy that enables docking different targeting ligands onto surface mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach which combination nano- milli-second...
The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA....
INTRODUCTION: Recent advancements in mRNA therapeutics have shown remarkable efficacy against pathogenic infections, prompting interest their application for other diseases, particularly cancer. However, one major challenge is the precise delivery of genetic material to specific cells and tissues. Extracellular vesicles like exosomes are emerging as promising carriers due favorable immunogenic profile, long circulatory half-life, ability cross biological barriers such blood-brain barrier,...
Despite the recent successes of immune checkpoint inhibitors (ICIs) in treating advanced melanoma, durable clinical responses still remain limited. To boost responses, agents that target regulators, such as Stimulator Interferon Genes (STING) agonist cyclic GMP-AMP (cGAMP), are being investigated. However, their translation is impeded by poor serum stability, rapid tissue clearance, and T-cell death due to off-target activation. Recently, a novel strategy termed Microbubble-assisted...
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<div>Abstract<p>Ionizing radiation is known to possess immune modulatory properties. However, how radiotherapy (RT) may complement with different types of immunotherapies boost antitumor responses unclear. In mice implanted EO771 syngeneic tumors, NL-201 a stable, highly potent CD25-independent agonist IL2 and IL15 receptors enhanced affinity for IL2Rβγ was given or without RT. Flow analysis Western blot performed determine the mechanisms involved. STING (−/−)...
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