A5045613950- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- MXene and MAX Phase Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Advanced Photocatalysis Techniques
- Photodynamic Therapy Research Studies
- Nanocluster Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Carbon and Quantum Dots Applications
- 2D Materials and Applications
- Advanced biosensing and bioanalysis techniques
- Catalytic Processes in Materials Science
- Sulfur Compounds in Biology
- Electrochemical sensors and biosensors
- Supramolecular Self-Assembly in Materials
- Ga2O3 and related materials
- RNA Interference and Gene Delivery
- Boron and Carbon Nanomaterials Research
- Photoacoustic and Ultrasonic Imaging
- Supramolecular Chemistry and Complexes
- Organic Light-Emitting Diodes Research
Nanyang Technological University
2018-2024
Brown University
2024
Ultralong room temperature phosphorescence is achieved from amorphous organic materials toward information encryption.
Photocatalysts derived from semiconductor heterojunctions that harvest solar energy and catalyze reactions still suffer low solar-to-hydrogen conversion efficiency. Now, MXene (Ti3 C2 TX ) nanosheets (MNs) are used to support the in situ growth of ultrathin ZnIn2 S4 (UZNs), producing sandwich-like hierarchical heterostructures (UZNs-MNs-UZNs) for efficient photocatalytic H2 evolution. Opportune lateral epitaxy UZNs on surface MNs improves specific area, pore diameter, hydrophilicity...
Uncontrolled cancer cell proliferation, insufficient blood flow, and inadequate endogenous oxygen lead to hypoxia in tumor tissues. Herein, a unique type of hypoxia-responsive human serum albumin (HSA)-based nanosystem (HCHOA) is reported, prepared by cross-linking the hypoxia-sensitive azobenzene group between photosensitizer chlorin e6 (Ce6)-conjugated HSA (HC) oxaliplatin prodrug-conjugated (HO). The HCHOA stable under normal partial pressure with size 100-150 nm. When exposed hypoxic...
Abstract Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal unharmed. Herein, we present new strategy based on single‐site cascade reaction tumor‐specific therapy that avoids off‐target toxicity tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme active exhibited within the microenvironment: Tumor‐specific...
Abstract The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels hydrogen peroxide (H 2 O ) dramatically limits antitumor efficiency by monotherapy. Herein, a novel TME‐modulated nanozyme employing tin ferrite (SnFe 4 , abbreviated as SFO) is presented for simultaneous photothermal therapy (PTT), photodynamic (PDT), chemodynamic (CDT). as‐fabricated SFO demonstrates both catalase‐like GSH peroxidase‐like activities. In...
The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow rate Fenton (pH 3–4). Herein, we report an ultrasmall trimetallic (Pd, Cu, Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property high photothermal conversion efficiency (62%) for synergistic tumor cell...
Multienzyme-mimicking redox nanozymes, curated by defect engineering, in synergy with immunotherapy offer promising prospects for safe and efficient cancer therapy. However, the spatiotemporally precise immune response often gets challenged off-target adverse effects insufficient therapeutic response. Herein, a tumor cell membrane coated nanozyme (CMO-R@4T1) is reported combinational second near-infrared window (NIR-II) photothermal immunotherapy. CMO-R@4T1 consists of Cu-doped MoO
Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising agents to overcome insufficient immunogenicity cells and poor immune response encountered in PTI still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic properties as well ability perturb redox homeostasis potentiate responsiveness. OMAs, assembled from charge-transfer complexes...
Abstract Photocatalysts derived from semiconductor heterojunctions that harvest solar energy and catalyze reactions still suffer low solar‐to‐hydrogen conversion efficiency. Now, MXene (Ti 3 C 2 T X ) nanosheets (MNs) are used to support the in situ growth of ultrathin ZnIn S 4 (UZNs), producing sandwich‐like hierarchical heterostructures (UZNs‐MNs‐UZNs) for efficient photocatalytic H evolution. Opportune lateral epitaxy UZNs on surface MNs improves specific area, pore diameter,...
Intracellular antioxidants such as glutathione (GSH) play a critical role in protecting malignant tumor cells from apoptosis induced by reactive oxygen species (ROS) and mechanisms of multidrug radiation resistance. Herein, we rationally design two multicomponent self-assembled photodynamic therapy (PDT) nanoagents, that is, Glup-MFi-c Glud-MFo-c, which consist respective GSH-passivation GSH-depletion linkers metal–organic frameworks encapsulated with photosensitizers for deeply...
Therapeutic efficacy of synergistic photodynamic therapy (PDT) and photothermal (PTT) is limited by complex conjugation chemistry, absorption wavelength mismatch, inadequate biodegradability the PDT–PTT agents. Herein, we designed biocompatible copper sulfide nanodot anchored folic acid-modified black phosphorus nanosheets (BP-CuS-FA) to overcome these limitations, consequently enhancing therapeutic efficiency PDT–PTT. In vitro in vivo assays reveal good biocompatibility commendable tumor...
The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA....
Targeted nanoparticles have been extensively explored for their ability to deliver payload a selective cell population while reducing off-target side effects. The design of actively targeted requires the grafting ligand that specifically binds highly expressed receptor on surface population. Optimizing interactions between targeting and can maximize cellular uptake subsequently improve activity. Here, we evaluated how density presentation ligands dictate nanoparticles. To do so, used...
Clinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development an ATS nanomedicine through self-assembly with Mn[Co(CN)6 ]2/3 □1/3 metal-organic frameworks (MOFs) that have hidden missing linkers. The defects in MOFs originating from linkers play key role increasing biological stability tumor accumulation ATS. Chlorin e6 (Ce6) can be co-loaded into for synergistic efficacy. In...
The efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications their biocompatibility intrinsic fluorescence imaging capabilities, making them suitable generation. Herein, we synthesized CD-based ultrasmall hybrid nanostructure possessing active sites Mo, Cu, IR-780 dye. After...
Abstract Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal unharmed. Herein, we present new strategy based on single‐site cascade reaction tumor‐specific therapy that avoids off‐target toxicity tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme active exhibited within the microenvironment: Tumor‐specific...
Abstract Deactivation of noble metal catalysts often occurs in many hydrocarbon reactions. In particular, sulfur species may cause significant poisoning catalysts, even at minimal concentration, due to strong metal–S bond formation. this work, hierarchical porous composites are prepared by integrating melamine foam with metal–organic frameworks, demonstrating excellent catalytic activity anti‐sulfur properties. Several techniques employed elucidate the mechanism poisoning. This study offers...
While Fe 3 O 4 nanoparticles are frequently exploited for the generation of reactive oxygen species (ROS) in cancer treatment, its therapeutic performance within a yolk–shell nanostructure Fenton reaction remains unexplored. To investigate potential, nanoreactor (YSN@ZnPc@HA) is fabricated by loading zinc phthalocyanine (ZnPc) into nanocomposite (YSN) consisting encapsulated MgSiO , followed modifying silica surface with hyaluronic acid (HA). ZnPc typical photosensitizer photodynamic...
Abstract Flexible chromium‐based metal‐organic frameworks (MOFs) possess unique structural properties on account of their intriguing breathing effect. However, synthesis often requires the use corrosive HF and bulk solvents. Herein, we report a facile 2‐step flexible MIL‐53 (Cr) MIL‐88B without using solvents acid modulator. This methodology was highly selective based type metal precursors used, giving two MOFs separately under similar synthetic procedure. The synthesized were fully...