A5100690999- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Microtubule and mitosis dynamics
- Skin Protection and Aging
- Enzyme Catalysis and Immobilization
- Acne and Rosacea Treatments and Effects
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Drug Solubulity and Delivery Systems
- Folate and B Vitamins Research
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Chemotherapy-induced cardiotoxicity and mitigation
Changchun University of Chinese Medicine
2018-2023
Jilin University
2015-2018
Jilin Medical University
2017
Abstract The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery genetic cargo to cells and tissues remains challenging. Here, we show an adaptive strategy that enables docking different targeting ligands onto surface mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach which combination nano- milli-second...
Abstract Triple‐negative breast cancer (TNBC) is the most lethal subtypes of cancer. Although chemotherapy considered effective strategy for TNBC, chemotherapeutics in current use are cytotoxic, meaning they target antiproliferative activity but do not inhibit tumor cell metastasis. Here, a TNBC‐specific targeted liposomal formulation epalrestat (EPS) and doxorubicin (DOX) with synergistic effects on both proliferation metastasis described. These liposomes biocompatible effectively cells...
Background: We previously developed cabazitaxel (CTX)-loaded human serum albumin nanoparticles (NPs-CTX) via a self-assembly method, and these NPs showed efficacy in prostate cancer therapy. Many studies have shown that the levels of folic acid (FA) receptor on surface various tumor cells are high. Therefore, FA-modified NPs-CTX may enhanced antitumor effects compared with unmodified NPs-CTX. Methods: were first prepared self-assembly, FA was conjugated through -NH2 groups to produce...
Clinical development of siRNA has been hindered by the lack an effective delivery system. Here, we report construction a novel system, sTOLP, which is based on cell penetrating peptide oleoyl-octaarginine (OA-R8) modified multifunctional lipid nanoparticles. sTOLP nanoparticles are composed protamine complexed core, OA-R8, cationic and PEGylated lipids, transferrin as targeting ligand. formulation was optimized characterized in vitro showed excellent gene silencing activity. In vivo,...
Vitamin D3 is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier deliver vitamin improve the stability and enhance treatment effect of D3. The liposomes, average cumulative penetration, retention in then evaluated compared with free Finally, liposomes rat photoaging model was appraised Haematoxylin-Eosin (H&E) staining assess histology changes after liposome treatment. results indicated that could significantly 1.65 times solution. repair surface...
Glioma is a deadly form of brain cancer. Doxorubicin cytotoxic against glioma cells. However, the blood-brain barrier (BBB) limits its ability to be delivered brain.Liposomes (R8PLP) formed from, 1,2-dioleoyl-3-trimethylammonium-propane chloride (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-(polyethylene glycol)-2000] (PEG-DSPE), cholesterol and egg phosphatidylcholine (ePC) were modified by cell-penetrating peptide R8 conjugated with oleic acid as novel method for...
Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes prepared by methanol injection-spray drying method. The response surface method was optimize formulation enhance encapsulation efficiency (EE%) particle size nifedipine after rehydration 114 nm. Surface morphology observed a scanning electron microscope (SEM) interaction ingredients assessed differential calorimetry (DSC). is improved 24.8 times forming proliposomes. In vitro...
Background/Aim: Cordycepin is an endogenous nucleoside with significant anticancer biological activity. The objective of this study was to develop targeted liposomes improve solubility and activity cordycepin. Materials Methods: We established transferrin-conjugated deliver cordycepin liver cancer cells evaluated the uptake effect. Results: were loaded Their average size 125.3 nm, drug encapsulation efficiency 65.3%. had good colloidal stability released slowly. Liposomal shown increase...
Purpose: A liposome-based siRNA–drug combination was evaluated as a potential therapeutic strategy to improve the curative effect. Methods: topoisomerase inhibitor SN38 prodrug combined with survivin siRNA through codelivery using transferrin (Tf)-L-SN38/P/siRNA. In this combination, conjugated cell penetrating peptide TAT polyethylene glycol (PEG) linker synthesize TAT-PEG-SN38. The amphiphilic TAT-PEG-SN38 used an ingredient of liposomes cellular uptake. Protamine added form electrostatic...
As a novel oral drug delivery system, proliposome was applied to improve the solubility of active components Ginkgo biloba extract (GbE). There are currently few reports focusing on pharmacokinetic characteristics GbE (GbP). A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous quantification GbP commercial tablet product (Ginaton) in rat plasma developed successfully validated. The comparative evaluation Ginaton plasma....
Background: Measuring free drug concentration following systemic administration of a liposomal is crucial aspect the assessment its in vivo behavior. Therefore we require an efficient method to separate plasma from encapsulated drug. Objectives: To study pharmacokinetics doxorubicin (DOX) released (L-DOX) rats. Methods: L-DOX was prepared with encapsulation efficiency 90% and injected intravenously into A solid-phase extraction (SPE) coupled UPLC-MS/MS used measure F-DOX rat without...
A series of 1,2-dihydroquinoline derivatives were synthesized and evaluated for cytotoxicity in HeLa, Hep G2 6HEK-293T cell lines. EEDQ2 was identified as a promising anti-cancer agent with low IC50 HeLa (18.55μg/ml) (14.53μg/ml) cells. For improving the antitumor activity tumor selectivity EEDQ2, we prepared transferrin (Tf)-modified liposomes (LPs) to deliver EEDQ2. When cells treated LP-delivered ROS level significantly enhanced, mitochondrial membrane potential reversed. Tf-LPs improved...
The present systematic study focused to investigate the oleic acid derivative of branched polyethylenimine (bPEI-OA)-functionalized proliposomes for improving oral delivery extract Ginkgo biloba (GbE). GbE were prepared by a spray drying method at varying ratios egg yolk phosphatidylcholine and cholesterol, optimized formulation was tailored with bPEI-OA obtain bPEI-OA-functionalized proliposomes. formulations characterized particle size, zeta potential, entrapment efficiency. release from...