A5057588710- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Anesthesia and Pain Management
- Nausea and vomiting management
- Natural product bioactivities and synthesis
- Hydrogen's biological and therapeutic effects
- Spine and Intervertebral Disc Pathology
- DNA and Nucleic Acid Chemistry
- Transplantation: Methods and Outcomes
- Simulation and Modeling Applications
- Anesthesia and Neurotoxicity Research
- Ginkgo biloba and Cashew Applications
- Bioactive natural compounds
- Inflammatory mediators and NSAID effects
- Neurological Disease Mechanisms and Treatments
- Advanced Combustion Engine Technologies
- MicroRNA in disease regulation
- Combustion and flame dynamics
- Intensive Care Unit Cognitive Disorders
- Click Chemistry and Applications
- Cell death mechanisms and regulation
- Engineering Structural Analysis Methods
- Cell Adhesion Molecules Research
- Advanced Algorithms and Applications
- Medicinal Plant Pharmacodynamics Research
Tianjin Medical University General Hospital
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2021-2024
Nanjing Medical University
2019-2024
Hefei Normal University
2024
Jinan Central Hospital
2023
Xinjiang University
2023
Shandong University
2023
Guangzhou First People's Hospital
2010-2021
Guangzhou Medical University
2010-2021
Background We hypothesized that the addition of a preoperative pericapsular nerve group (PENG) block to intra-articular local anesthetic injection would improve analgesia after total hip arthroplasty. Method In this double-blinded trial, 71 patients scheduled for primary arthroplasty were randomized receive PENG with 20 mL 0.5% ropivacaine (PENG group) or saline (placebo group). All received an by surgeon completion procedure. The outcome was highest pain score reported in recovery room....
Circular RNAs (circRNAs) have a regulatory function on inflammation and autophagy, of which rno-circRNA_010705 (circLrp1b) appears to be significantly up-regulated following traumatic brain injury (TBI). Dexmedetomidine (DEX) shows improvement effects in TBI by inhibiting NLRP3/caspase-1. However, whether circLrp1b plays critical roles DEX-mediated attenuation the underlying mechanisms remain unclear. After was established rats controlled cortical impact (CCI) cause trauma, they received an...
Laminar burning velocities and Markstein lengths of 2,5-dimethylfuran (DMF)−air−N2/CO2 premixed mixtures at the atmospheric pressure initial temperature 393 K over three different dilution ratios were obtained by using outwardly propagating spherical flame high-speed schlieren photograph system. Addition diluent was used to simulate effects exhaust gas recirculation on propagation. The results show that both unstretched propagation speed laminar velocity decrease with increase ratio. length...
The abnormally high nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) inflammasome activity is a typical characteristic of traumatic brain injury (TBI). Dexmedetomidine (Dex) highly selective α-2 adrenergic agonist that inhibits the activation NLRP3. Thus, it was hypothesized Dex could attenuate TBI by inhibiting NLRP3 in hippocampus. Rats were subjected to controlled cortical impact method induce TBI, and treated with Dex. effect treatment on...
Objective: This study aimed to evaluate the anti-inflammatory effects of petal and stamen extracts saffron crocus ( Crocus sativus ) explore underlying mechanism. Methods: Local systemic inflammation models were used investigate C. sativus. A xylene-induced model or lipopolysaccharide (LPS)-induced was in this study. each administered mice xylene LPS by gavage for 14 d at 0.1 0.4 g/kg doses, respectively. Enzyme-linked immunosorbent assay (ELISA) measure concentrations tumor necrosis factor...
Pseudolaric acid B (PLAB) is one of the major bioactive components Pseudolarix kaempferi. It has been reported to exhibit inhibitory effect on cell proliferation in several types cancer cells. However, there no report elucidating its glioma cells and organ toxicity vivo. In present study, we found that PLAB inhibited growth U87 glioblastoma a dose-dependent manner with IC(50)~10 μM. Flow cytometry analysis showed apoptotic death mediated by was accompanied cycle arrest at G2/M phase. Using...
Measurement of laminar burning velocities and Markstein lengths were made for the diethyl ether−air mixtures at different equivalence ratios, initial temperatures, pressures by using spherically propagating flame schlieren photography method. The results show that stretched propagation speeds, unstretched velocities, mass increase with temperature. Although decreases are decreased pressure, also ratio. On basis experimental data, a correlation is obtained velocity versus temperature pressure...
Abstract Storage tank fires often occur together with explosion causing major losses. Fifty storage occurring during the past 50 years in China are reviewed this article. The results show that over 64% accidents petrochemical plants, petroleum refineries and oil depots. majority of resulted explosions, i.e., 82% explosions. fire disaster occurred mostly maintenance, repair, loading or unloading. Twenty‐seven percent due to human errors including operations maintenance. This article...
Ginseng fruit saponins (GFS) extracted from the ginseng are bioactive triterpenoid saponin components. The aim of present study was to develop a drug delivery system called proliposome using sodium deoxycholate (NaDC) as bile salt improve oral bioavailability GFS in rats. liposomes were prepared by conventional ethanol injection and formed solid proliposomes (P-GFS) spray drying method on mannitol carriers. formulation P-GFS optimized response surface methodology. physicochemical properties...
Background: Lung inflation with hydrogen is an effective method to protect donor lungs from lung ischemia-reperfusion injury (IRI). This study aimed examine the effect of 3% during cold ischemia phase on pyroptosis in grafts rats. Methods: Adult male Wistar rats were randomly divided into sham group, control oxygen (O 2 ) and (H group. The group underwent thoracotomy but no transplantation. In deflated for h. O H groups, inflated 40% + 60% N 57% , respectively, at 10 ml/kg, gas was replaced...
This paper introduces a kind of double-row reed–nylon net combined sand barrier. Using the computational fluid dynamics (CFD) method and Euler–Euler double-fluid model, new fences’ windproof effect airflow features are simulated under different porosities spacings, optimal configuration parameters selected. The fence has better performance practical significance than reed nylon fences. fences with porosity 0.3–0.4 spacing 28 H provide longer protection range wind effect. Considering serious...
Abstract Pre‐exposure to volatile anesthetics inhibits inflammation induced by various stimuli, including surgical procedures and ischemia. We hypothesize that may induce anti‐inflammatory effects via a mechanism involving regulation of histone deacetylases (HDACs). 1.5% isoflurane for 0.5 h [measured cytokine production tumor necrosis factor‐ɑ, interleukin‐8 (IL‐8) IL‐1β] in both human THP‐1 cells primary peripheral blood monocytes stimulated lipopolysaccharide. In cells, coadministration...
The effective delivery system plays an important role in the application of siRNA antitumor study. However, until now, researches on systems targeting hepatocarcinoma cells are still being explored. Here we designed and prepared a novel system, cRGD-PSH-NP, which was based modified polyethyleneimine (PSH) DSPE-PEG2000-cRGD. cRGD-PSH-NP loaded with survivin (cRGD-PSH-NP/S) composed egg phosphatidylcholine, cationic PSH, PEGylated lipids, siRNA, cRGD peptide as ligand. formulations...
As a novel oral drug delivery system, proliposome was applied to improve the solubility of active components Ginkgo biloba extract (GbE). There are currently few reports focusing on pharmacokinetic characteristics GbE (GbP). A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous quantification GbP commercial tablet product (Ginaton) in rat plasma developed successfully validated. The comparative evaluation Ginaton plasma....
Efficient and stable delivery system of antisense oligonucleotide (ASO) is important urgently needed. Here, an ASO system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC palmitic acid modified R8 (R8-PA) was prepared to deliver kind ASO, LOR-2501. The characteristics the nanoparticles cellular uptake LOR-2501 in HeLa cells A549 were studied. Lp-PPRP showed suitable particle size zeta potential combine with LOR-2501; Lp-PPRP/LOR 276.87 ± 5.63 nm 18.03...