A5020441815- Spectroscopy Techniques in Biomedical and Chemical Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Engineering Applied Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Liver Disease and Transplantation
- Spectroscopy and Chemometric Analyses
- Fluid Dynamics and Vibration Analysis
- Vibration and Dynamic Analysis
- Transition Metal Oxide Nanomaterials
- Pediatric Hepatobiliary Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- Viral-associated cancers and disorders
- Diet, Metabolism, and Disease
- Renal cell carcinoma treatment
- Nuclear Physics and Applications
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
Niigata Prefectural Central Hospital
2024-2025
Tohoku University
1976-2025
Niigata University Medical and Dental Hospital
2009-2024
Kitami Institute of Technology
2021-2024
Niigata University
2008-2024
Fukuyama City Hospital
2023
Shizuoka Cancer Center
2023
Nara Medical University
2023
Saiseikai Ibaraki Hospital
2023
DMG Mori (Japan)
2021
With the advent of effective systemic therapy, transarterial chemoembolization (TACE) is established as a highly locoregional treatment modality for carefully selected patients with hepatocellular carcinoma (HCC). This randomized controlled trial was conducted to clarify whether selective TACE drug-eluting beads (DEB-TACE) loaded epirubicin or conventional (cTACE) epirubicin-ethiodized oil might be more obtaining complete response(CR) in HCC.Between March 2016 and May 2019, Child-Pugh class...
Nitroxoline is a broad-spectrum drug that effectively treats urinary tract infections (UTIs) without causing fever. Therefore, estimating the concentrations of nitroxoline spiked in human serum worth investigating. This study introduces an efficient spectrophotometric method for quantifying diverse matrices, including bulk samples, Nibiol® tablets, and samples with nitroxoline. offers direct, user-friendly, rapid, rigorously validated approach determining content these various sample...
An immunoliposome (80 nm in diameter) encapsulating a Ru complex with two aminobutyl moieties was prepared to detect the presence of hemagglutinin molecules, which play an important role influenza virus infection. The highly sensitive detection accomplished by electrochemiluminescence (ECL) from adsorbed onto Au electrodes after competitive immunoreactions. This method clarified that adsorption electrode factor obtaining high sensitivity. Optimization analytical conditions enabled...
The crystal structure analysis of Pb2CrO5 is determined by comparison with powder x-ray and electron diffraction data. monoclinic: c2/m. All the atom positions are considering calculated values d spacings, line intensities, bond lengths, angles. A new set lattice parameters a=14.018, b=5.683, c=7.143 Å, β=115.23 °. preliminary result on photoconductivity in a ceramic disk also given.
Purpose.: To study the role played by HB-EGF in corneal epithelial wound healing. Methods.: A 2-mm was created keratinocyte-specific, HB-EGF–deficient mice—HBlox/lox:K-5Cre (HB−/−)—and speed of healing compared with that wild-type (WT) mice. Cultured confluent mouse cells (MCECs) from WT and HB−/− mice were scraped, bare area measured. The proliferation MCECs determined BrdU incorporation. degree attachment also determined. mRNA expression EGF family cell adhesion molecules real-time PCR....
The etiology of non-alcoholic fatty liver disease (NAFLD) consists various factors, including neural signal pathways. However, the molecular mechanisms autonomic signals influencing NAFLD progression have not been elucidated. Therefore, we examined involvement gut-liver axis in development and tested therapeutic effect modulation this study. To test contribution axis, with respect to body weight, hepatic steatosis, fibrosis, intestinal tight junction, microbiota short-chain acids models...
ABSTRACT Serotonin (5-HT) is one of the key bioamines nonalcoholic fatty liver disease (NAFLD). Its mechanism action in autonomic neural signal pathways remains unexplained; hence, we evaluated involvement 5-HT and related signaling via nerves NAFLD. Diet-induced NAFLD animal models were developed using wild-type melanocortin 4 receptor (MC4R) knockout (MC4RKO) mice, effects axis on physiology, its receptors (HTRs), lipid metabolism-related genes assessed by applying hepatic nerve blockade....
Purpose: To evaluate the effect of preoperative intravitreal bevacizumab (IVB) on surgical procedures, visual prognosis, and postoperative complications, especially vitreous hemorrhage, in cases with proliferative diabetic retinopathy (PDR). Materials Methods: Seventy-one eyes 54 consecutive patients (23 18 women, 48 36 men) were investigated this study. Twenty-five received IVB one to 30 days before vitrectomy (Bevacizumab Group) other 46 had alone (Control Group). The best-corrected...
A 70-year-old man with insulinoma-associated antigen-2 autoantibodies developed diabetes mellitus (DM) without ketoacidosis after starting nivolumab to treat advanced gastric cancer. He subsequently exhibited preserved insulin-secretion capacity for over one year. Immune checkpoint inhibitors (ICIs) infrequently cause type 1 DM associated the rapid loss of insulin secretion and as an immune-related adverse event. ICIs may also non-insulin-dependent by inducing resistance if there is islet...
4518 Background: Transarterial chemoembolization (TACE) with selective catheterization into the segmental or subsegmental hepatic arteries supplying HCC is often performed to achieve complete local control of in patients a limited number small sized nodules. To clarify which TACE drug-eluting beads loaded epirubicin (DEB-TACE) conventional epirubicin-lipiodol (cTACE) can response (CR) more frequently, we randomized controlled trial DEB-TACE vs. cTACE. Methods: Between March 2016 and May...
Bcl11b encodes a zinc-finger transcription factor and functions as haploinsufficient tumor suppressor gene. Bcl11b(KO/KO) mice exhibit differentiation arrest of thymocytes during beta-selection has been observed with other mouse models involving knockouts genes in the Wnt/beta-catenin signaling pathway. Recurrent chromosomal rearrangement at BCL11B locus occurs human T-cell leukemias, but it is not clear how such would contribute to lymphomagenesis. To address this issue, we studied clonal...
We encountered a small cell lung cancer (SCLC) patient with intertrabecular vertebral metastasis (IVM). A 59-year-old man was admitted to our hospital weight loss. 18F-fluorodeoxyglucose positron emission tomography (FDG PET)-CT demonstrated the uptake of fluorodeoxyglucose in hilum left and whole-body bones. Despite intensive support, died within month. Subsequent autopsy revealed lesion consisting round cells lung. The were found have spread through replacement bone marrow while sparing...
Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines, is drug that expected have therapeutic effects on obesity. Here, we report the efficacy daisaikoto in MC4R-KO mice. Eight-week-old male (n = 12) were divided into three groups as follows: SD group, which fed standard diet; HFD and DSK diet containing 10% daisaikoto. After four-week observation period, each group sacrificed samples collected....
Objectives. To compare the use of an antireflux metal stent (ARMS) with that a conventional covered self-expandable (c-CSEMS) for initial stenting malignant distal biliary obstruction (MDBO). Materials and Methods. We retrospectively investigated 59 consecutive patients unresectable MDBO undergoing endoscopic drainage. ARMS was used in 32 c-CSEMS 27. Technical success, functional complications, causes recurrent (RBO), time to RBO (TRBO), reintervention were compared between groups. Results ....
Endoscopic ultrasound (EUS)-guided transmural drainage (EUS-TD) was recently developed and has proven to be a useful alternative approach for various intra-abdominal conditions [1] [2] [3]. In this procedure, an intrathoracic passage should avoided, because it causes severe complications, such as mediastinitis [4] [5]. Unfortunately, however, is difficult confirm whether puncture route can used pass the thorax using EUS observation alone when approaching from gastric cardia. Here, we...
Endoscopic US-guided biliary drainage (BD) is performed for various types of obstruction and mainly indicated unsuccessful conventional transpapillary endoscopic retrograde cholangiodrainage. In US BD, an extra-anatomic route between the gastrointestinal (GI) tract system created with a covered metallic stent or plastic stent. Procedural BD include hepaticogastrostomy, hepaticojejunostomy (after gastrectomy), choledochoduodenostomy, hepaticoduodenostomy, gallbladder drainage. The technical...
In alcoholic liver cirrhosis (LC) patients, obesity has become a problem that progresses into dysfunction. Herein, we investigated the relationship between prognosis of steatohepatitis and body weight, along with fat accumulation in patients LC. We conducted single-center retrospective study, enrolled 104 LC without hepatocellular carcinoma (HCC) based on histological clinical evidence, factors related to poor using multivariate Cox regression cluster analyses. analysis revealed three...