A5002464755- Autophagy in Disease and Therapy
- Aortic aneurysm repair treatments
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Vascular Procedures and Complications
- Aortic Disease and Treatment Approaches
- Shoulder Injury and Treatment
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- Gastrointestinal Tumor Research and Treatment
- Animal Virus Infections Studies
- MRI in cancer diagnosis
- T-cell and Retrovirus Studies
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- CRISPR and Genetic Engineering
- Pain Management and Treatment
- Infectious Aortic and Vascular Conditions
Tohoku University
2024
Sendai Kousei Hospital
2011-2022
Okayama University Hospital
2022
Furuno (Japan)
2021
St. Marianna University School of Medicine
2015-2019
Hokkaido University
2015
Virginia Commonwealth University
2010
The University of Texas MD Anderson Cancer Center
2005-2010
Shimane University
2008
Zero to Three
2008
Abstract The mammalian target of rapamycin (mTOR) is a downstream effector the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and central modulator cell proliferation in malignant gliomas. Therefore, targeting mTOR considered promising therapy for However, mechanisms underlying cytotoxic effects selective inhibitor, rapamycin, on glioma cells are poorly understood. purpose this study was thus to elucidate how exerts its cells. We showed that induced autophagy...
Malignant gliomas are common primary tumors of the central nervous system. The prognosis patients with malignant glioma is poor in spite current intensive therapy and thus novel therapeutic modalities necessary. Imatinib mesylate, a tyrosine kinase inhibitor, effective including leukemias but not as monotherapy for glioma. Recently, it thought that adequate modulation autophagy can enhance efficacy anticancer therapy. outcome manipulation, however, seems to depend on initiator, combined...
Conditionally replicating adenoviruses (CRAds) can be engineered to replicate selectively in cancer cells and cause cancer-specific cell lysis; thus they are considered a promising therapy.To elucidate the mechanisms by which CRAds induce death, we infected normal human fibroblasts (MRC5, telomerase negative), malignant glioma (U373-MG U87-MG), cervical (HeLa), prostate (PC3) (all positive) with regulated reverse transcriptase promoter (hTERT-Ad) or control nonreplicating (Ad-GFP)....
Abstract DNA-dependent protein kinase (DNA-PK) plays a major role in the repair of DNA double-strand breaks induced by ionizing radiation (IR). Lack DNA-PK causes defective break and radiosensitization. In general, cell death IR is considered to be apoptotic. On other hand, nonapoptotic death, autophagy, has recently attracted attention as novel response cancer cells chemotherapy IR. Autophagy degradation system characterized prominent formation double-membrane vesicles cytoplasm. Little...
Autophagy, or programmed cell death type II, is one of the responses cancer cells to various therapies, including ionizing radiation. Recently, we have shown that radiation induces autophagy, but not apoptosis, in malignant glioma lines. Autophagy mainly regulated by mammalian target rapamycin (mTOR) pathway. The Akt/mTOR pathway also mediates oncogenesis and radioresistance. Thus, hypothesized inhibiting this has both an anticancer radiosensitizing effect activating autophagy. purpose our...
Abstract Background and Aims: The aim was to determine the role of T‐helper (Th)1/Th2 cytokine responses in clinical outcome patients with acute liver injury. Methods: serum levels cytokines, interleukin (IL)‐18, gamma‐interferon (IFN‐γ), IL‐10 IL‐4 were measured 20 fulminant hepatic failure (FHF), 18 hepatitis (AH), 30 chronic viral cirrhosis (LC) patients. Thirteen cases from intensive care unit (ICU) there 21 healthy volunteers. Immunohistochemical staining biopsies for IL‐18 expression...
Abstract Purpose: Glioblastoma is the most common primary malignant tumor in brain. It aggressively invades surrounding parenchyma, often allowing to progress after surgery. Accumulating evidence has shown that phosphorylated p21-activated kinase 1 (Pak1), a mediator of small guanosine triphosphatases, plays role proliferation, survival, and invasiveness cancer cells. Thus, we examined patterns Pak1 expression glioblastoma sought determine whether level cells associated with patient survival...
Telomere 3' overhang-specific DNA oligonucleotides (T-oligos) induce cell death in cancer cells, presumably by mimicking telomere loop disruption. Therefore, T-oligos are considered an exciting new therapeutic strategy. The purpose of this study was to elucidate how exert antitumor effects on human malignant glioma cells vitro and vivo. We demonstrated that inhibited the proliferation through induction nonapoptotic mitochondria hyperpolarization, whereas normal astrocytes were resistant...
To describe the candy-plug technique using an Excluder aortic extender for distal occlusion of a large false lumen aneurysm in chronic dissection.A 60-year-old female patient with history type B dissection and high-dose steroid use Churg-Strauss syndrome developed 6.2 cm maximum diameter aneurysm. She underwent thoracic endovascular repair from left common carotid artery to descending aorta cover proximal entry at level arch, coil embolization subclavian artery. occlude reentry just below...
Abstract Background and Aim: We analyzed the expression of antigen‐processing antigen‐presenting molecules in surgically resected fresh samples human hepatocellular carcinoma (HCC) tissue to elucidate a mechanism immune escape. also examined interleukin (IL)‐10 protein, which might act downregulate molecules. Methods: Twenty‐eight HCC obtained by surgical resection were for β2‐microglobulin, heat‐shock protein (HSP)‐70, leukocyte antigen (HLA) class‐I, CD80 (B7‐1), CD86 (B7‐2) IL‐10...
Anticancer therapies can induce autophagy in tumor cells and the role of these may depend on type tumor, stage tumorigenesis, nature extent insult. Appropriate modification autophagy, that is, suppression cell-protective or enhancement cell-killing could augment cytotoxicity caused by anticancer therapy. Imatinib mesylate is an inhibitor tyrosine kinases used for therapy patients with tumors including leukemias, but not effective as a monotherapy malignant glioma. To seek strategy to...
MAGE gene family encodes peptides recognized by autologous cytotoxic T lymphocytes in a major histocompatibility complex (MHC) class-I restricted fashion. In the present study, we have performed reverse-transcription polymerase chain reaction (RT-PCR) for genes, as well immunohistochemical analysis and Western blotting of MAGE-1 -3 proteins 33 surgically resected hepatocellular carcinomas (HCCs). mRNAs were constitutively expressed exclusively 78 42% HCCs respectively. On...
Grading System to Categorize Breast MRI in BI-RADS 5th Edition: A Multivariate Study of Mass Descriptors Terms Probability MalignancyKeishi Fujiwara1, Takayuki Yamada2, Yoshihide Kanemaki3, Satoko Okamoto3, Yasuyuki Kojima4, Koichiro Tsugawa4 and Yasuo Nakajima1Audio Available | Share
BBR3610 is a polynuclear platinum compound, in which two platinums are linked by spermine-like linker, and studies variety of cancers, including glioma, have shown that it more potent than conventional works different means. Identifying the mechanism action would help developing drug further for clinical use. Previous work showed does not induce immediate apoptosis but results an early G2/M arrest. Here, we report induces autophagy glioma cells. Increased was also seen intracranial...
<b><i>Purpose:</i></b> Severe oral and pharyngeal mucositis is one of the most critical toxicities known to lead discontinuation chemoradiotherapy (CRT) for head neck cancer (HNC). Hangeshashinto (TJ-14) a Kampo medicine that relieves chemotherapy-induced mucositis. We investigated effect TJ-14 on mucositis, nutritional status, completion rate CRT. <b><i>Methods:</i></b> The study group comprised patients with advanced HNC who were treated...