A5103072392- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Peripheral Artery Disease Management
- Advanced Combustion Engine Technologies
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Treatments and Studies
- Vehicle emissions and performance
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Catalytic Processes in Materials Science
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Biodiesel Production and Applications
- Myasthenia Gravis and Thymoma
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Shoulder Injury and Treatment
- Brain Metastases and Treatment
Furuno (Japan)
2019-2025
Hyogo Medical University
2011-2021
Shell (Japan)
2007-2020
Tokyo Metropolitan Komagome Hospital
2007-2019
Center for Innovation
2015-2016
Medical University of Silesia
2016
Cardiovascular Research Foundation
2013-2015
Shibuya (Japan)
2011-2015
Sakurabashi Watanabe Hospital
2008-2012
The University of Tokyo
2011
Purpose Few randomized trials have demonstrated survival benefit of combination chemotherapy involving new agents plus cisplatin compared with classic in advanced non-small-cell lung cancer (NSCLC). The primary aim this study was to test whether docetaxel (DC) improves vindesine (VdsC) patients previously untreated stage IV NSCLC. Patients and Methods Eligible, IV, chemotherapy-naive (n = 311) were randomly assigned receive 60 mg/m 2 intravenously on day 1 80 a 3- or 4-week cycle, 3 days 1,...
Mutations in mitotic checkpoint genes have been detected several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from instability reported many lung cancers. To determine whether alteration of regulators is involved carcinogenesis tumor progression primary cancer, we screened the genomic DNA sequence 30 cancer cell lines tumors for a mutation hBUB1 gene. First, designed 26 sets intron-based primers amplify each 25 exons gene examine...
This study evaluated whether optical frequency domain imaging (OFDI) could identify various coronary calcifications and accurately measure calcification thickness in comparison with histopathology. A total of 902 pathological cross-sections from 44 artery specimens human cadavers were examined to compare OFDI histological images. Histological was classified into four different types: (i) superficial dense calcified plates, (ii) deep intimal calcification, (iii) scattered microcalcification,...
The laminin alpha5 chain is a component of laminin-10 (alpha5beta1gamma1) and -11 (alpha5beta2gamma1). In this study, we have screened 113 overlapping synthetic peptides from the globular domain (G-domain) for cell attachment activity with B16-F10 cells using peptide-coated dishes. Eleven attachment-active were identified. vivo experimental pulmonary metastasis primary tumor growth assays found that 4 11 inhibited increased apoptosis. These four also blocked migration, invasion,...
The clinical characteristics and prognostic factors of thymic carcinoma have not been investigated in detail because its rarity. aim this study was to elucidate the disease profile, outcomes, for survival among patients with advanced treated palliative-intent chemotherapy.A retrospective review conducted medical records 40 chemotherapy between 1991 2011 our institution. Clinical demographics, histology, overall survival, expected predict were analyzed. Differences assessed using Kaplan-Meier...
Experimental investigations were previously conducted with a direct-injection diesel engine the aim of reducing exhaust emissions, especially nitrogen oxides (NOx) and particulate matter (PM). As result that work, combustion concept, called Modulated Kinetics (MK) combustion, was developed reduces NOx smoke simultaneously through low-temperature premixed to achieve cleaner engine. In subsequent it found applying low compression ratio effective in expanding MK region on high-load side. The...
Background: Previous intravascular ultrasound (IVUS) studies have reported that a tiny reference cross-sectional area (CSA), stent under-expansion, asymmetry, edge dissection, and tissue protrusion are associated with target lesion revascularization (TLR) after coronary intervention. In the lower limb, however, it has not been these findings correlate TLR endovascular therapy (EVT). Methods Results: A total of 236 consecutive superficial femoral artery (SFA) lesions in patients who underwent...
Background— Despite a sufficient coronary blood flow after primary percutaneous intervention for patients with ST-segment–elevation myocardial infarction; some have poor outcome because of microcirculatory damage. This study evaluates whether the thermodilution-derived parameters immediately predict early microvascular damage and midterm outcomes in infarction. Methods Results— Using pressure sensor/thermistor-tipped guidewire, we measured index resistance at maximum hyperemia, pattern was...
To identify intravascular ultrasound (IVUS) measurements that can predict angiographic in-stent restenosis (ISR) following nitinol stent implantation in superficial femoral artery (SFA) lesions.A retrospective review was conducted of 97 patients (mean age 72.9±8.9 years; 63 men) who underwent IVUS examination during endovascular treatment 112 de novo SFA lesions between July 2012 and December 2014. Self-expanding bare stents were implanted 46 paclitaxel-eluting 39 lesions. Six months after...
Gefitinib is a potent drug used in the treatment of nonsmall-cell lung cancer (NSCLC). acts by inhibition epidermal growth factor receptor tyrosine kinase. Clinical trials have confirmed efficacy gefitinib for NSCLC. Adverse reactions, although frequent, are mild, and include acne-like skin rash diarrhoea. The present study describes case 56-yr-old male with NSCLC who, 4 weeks after gefitinib, suffered from severe alveolar haemorrhage diagnosed bronchoalveolar lavage. This first report an...
Abstract Recently, we reported that the laminin α5 synthetic peptide A5G27 (RLVSYNGIIFFLK, residues 2,892-2,904) binds to CD44 receptor of B16-F10 melanoma cells via glycosaminoglycans on and inhibits tumor cell migration, invasion, angiogenesis in a dominant-negative manner. Here, have identified potential mechanism activity using WiDr human colorectal carcinoma cells. bound heparin-like chondroitin sulfate B glycosaminoglycan side chains CD44. Cell binding fibroblast growth factor (FGF2)...