A5103073872- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Semiconductor Lasers and Optical Devices
- Venous Thromboembolism Diagnosis and Management
- Iron Metabolism and Disorders
- Millimeter-Wave Propagation and Modeling
- Photonic and Optical Devices
- Acute Myocardial Infarction Research
- Advanced Photonic Communication Systems
- Muscle and Compartmental Disorders
- Wireless Communication Networks Research
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Telecommunications and Broadcasting Technologies
- Power Line Communications and Noise
- Antiplatelet Therapy and Cardiovascular Diseases
- Photoacoustic and Ultrasonic Imaging
- Advanced MIMO Systems Optimization
- Atherosclerosis and Cardiovascular Diseases
Augusta University
2017-2023
Hyogo Medical University
2014-2022
Musashino Red Cross Hospital
2022
Augusta University Health
2020
Kawasaki Hospital
2011-2016
Stanford University
2016
Stanford Medicine
2016
Morinomiya Hospital
2015
Fujitsu (Japan)
1987-2011
This study evaluated whether optical frequency domain imaging (OFDI) could identify various coronary calcifications and accurately measure calcification thickness in comparison with histopathology. A total of 902 pathological cross-sections from 44 artery specimens human cadavers were examined to compare OFDI histological images. Histological was classified into four different types: (i) superficial dense calcified plates, (ii) deep intimal calcification, (iii) scattered microcalcification,...
Chronic adventitial and medial infiltration of immune cells play an important role in the pathogenesis abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to inhibit atherosclerosis by activating anti-inflammatory G protein-coupled receptor GPR109A [also known as hydroxycarboxylic 2 (HCA2)] expressed on cells, blunting activation inflammatory cell infiltration. Here, we investigated niacin regulating AAA formation.
Objective: Copper (Cu) is essential micronutrient, and its dysregulation implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) delivers via the chaperone Atox1 (antioxidant 1) to secretory enzymes, such as lysyl oxidase, excludes excess Cu. Lysyl oxidase shown protect against AA formation. However, role mechanism of pathogenesis remain unknown. Approach Results: Here, we show that chelator markedly inhibited Ang II...
Background: Although statins vary in their effectiveness lowering low-density lipoprotein cholesterol (LDL-C) and increasing high-density (HDL-C) levels, there is little evidence that the degree of these changes can explain cardiac risk reduction Japan. Our objective was to compare efficacy on serum lipid levels explore association between those events patients after percutaneous coronary intervention (PCI). Methods Results: The 743 consecutive who underwent PCI from 2001 2008 were...
To identify intravascular ultrasound (IVUS) measurements that can predict angiographic in-stent restenosis (ISR) following nitinol stent implantation in superficial femoral artery (SFA) lesions.A retrospective review was conducted of 97 patients (mean age 72.9±8.9 years; 63 men) who underwent IVUS examination during endovascular treatment 112 de novo SFA lesions between July 2012 and December 2014. Self-expanding bare stents were implanted 46 paclitaxel-eluting 39 lesions. Six months after...
High-fat meal (HFM) consumption can produce acute lipemia and trigger myocardial infarction in patients with atherosclerosis, but the mechanisms are poorly understood. Erythrocytes (red blood cells, RBCs) intimately interact inflammatory cells vessels play a complex role regulating vascular function. Chronic high-fat feeding mice induces pathological RBC remodeling, suggesting novel link between HFM, RBCs, dysfunction. However, whether HFM induce remodeling humans is unknown. Ten healthy...
Purpose: To identify intravascular ultrasound (IVUS) findings that predict midterm stent patency in femoropopliteal (FP) lesions. Materials and Methods: A retrospective analysis was undertaken of 335 de novo FP lesions 274 consecutive patients (mean age 72.4±8.2 years; 210 men) who had IVUS assessment before after successful implantation. The mean lesion length 13.2±9.8 cm. primary outcome at 24 months, defined as freedom from major adverse limb event (MALE) in-stent restenosis (ISR). MALE...
We performed an ex vivo study to investigate optical coherence tomography (OCT) imaging for differentiating several types of neointimal tissue during the later phases after bare-metal stent (BMS) implantation as compared with histologic results.OCT was in 6 autopsy hearts 10 BMS implant duration >4 years. OCT qualitative characterization based on structure and classified homogeneous pattern, heterogeneous pattern visible struts, or invisible struts. Corresponding histological analyses each...
Introduction: Abdominal aortic aneurysms (AAA) are characterized by localized inflammation, extracellular matrix degradation, and apoptosis of smooth muscle cells, which together lead to progressive irreversible dilation. Major risk factors for AAA include smoking aging, both prominently alter gene expression via epigenetic mechanisms, including histone methylation (me) acetylation (ac). However, little is known about epigenomic dynamics during formation. Here, we profiled modification...
Anemia and chronic kidney disease (CKD) are common in patients with heart failure preserved left ventricular fraction (HFpEF). However, it is entirely unknown about the impact of anemia on prognosis HFpEF CKD. In this study, we investigated optimal hemoglobin (Hb) levels to predict CKD.We prospectively examined 523 consecutive enrolled Japanese syndrome ejection registry. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL /min/1.73 m2. The prevalence 78% by using World...
The purpose of this study was to verify whether the concept coronary blood flow reserve can be applied patients with critical limb ischemia who are undergoing endovascular treatment (EVT) for isolated infrapopliteal lesions.Forty diagnosed (Rutherford category 5) were EVT lesions prospectively enrolled. All treated conventional balloon angioplasty without stent placement. After successful EVT, a pressure/temperature sensor-tipped guidewire positioned in proximal popliteal artery. Using...
Background: Although previous intravascular ultrasound (IVUS) studies reported that the drug-eluting stent (DES) has successfully decreased in-stent restenosis (ISR) by inhibiting neointimal hyperplasia (NIH) in coronary artery lesion, no IVUS data for vascular response after DES implantation superficial femoral (SFA) have been published. Methods and Results: We retrospectively analyzed 38 de novo SFA lesions from 32 patients who underwent endovascular therapy (EVT) with self-expanding...
Prostaglandin D2 (PGD2) released from immune cells or other cell types activates its receptors, D prostanoid receptor (DP)1 and 2 (DP1 DP2), to promote inflammatory responses in allergic lung diseases. Prostaglandin-mediated inflammation may also contribute vascular diseases such as abdominal aortic aneurysm (AAA). However, the role of DP receptors pathogenesis AAA has not been systematically investigated. In present study, DP1-deficient mice pharmacological inhibitors either DP1 DP2 were...
Anemia and iron deficiency (ID) are common in patients with heart failure (HF) intravenous (IV) administration of to hospitalized for decompensated HF ID improves outcome. The diagnosis routine practice is based on serum ferritin transferrin saturation (TSAT) but both have limitations; alternatives should be considered. Reticulocyte hemoglobin equivalent (Ret-He) reflects content reticulocytes its clinical utility remains uncertain. We prospectively enrolled 142 HF. Sixty five percent had as...