A5070194034- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Peripheral Nerve Disorders
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Lipoproteins and Cardiovascular Health
- Nerve Injury and Rehabilitation
- Dysphagia Assessment and Management
- Facial Nerve Paralysis Treatment and Research
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Surgery and Rehabilitation
- Advanced Radiotherapy Techniques
- Muscle activation and electromyography studies
- Voice and Speech Disorders
- Hormonal Regulation and Hypertension
- Neurogenetic and Muscular Disorders Research
- Organ Donation and Transplantation
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Ophthalmology and Eye Disorders
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- EEG and Brain-Computer Interfaces
Tokai University
2007-2025
Niigata University
2013-2024
Niigata City General Hospital
2023
Sanin Rosai Hospital
1994-2021
Shonan Oiso Hospital
2005-2021
Niigata University Medical and Dental Hospital
2016-2021
Tokai University Hospital
2012-2020
Kyoto University
2011-2018
Shiga Medical Center for Adults
2017
Tosei General Hospital
2017
Abstract XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined expression and function of in normal urothelium TCC. We also therapeutic effect xiap AS PODN on cell cycle apoptosis multidrug‐resistant T24 bladder cancer cells. was moderately expressed transitional epithelium with prominent superficial layer Seventy‐nine 108 (73.15%) tumor samples were positive for protein, but positivity not correlated stage or grade. Moreover, 4...
The death receptor Fas (Apo1/CD95) and ligand (FasL) system is recognised as a major pathway for the induction of apoptosis in vivo, antiapoptosis via its blockade plays critical role carcinogenesis progression several malignancies. However, function Fas–FasL urothelial cancer (UC) has not been elucidated. We therefore investigated expression Fas, FasL Decoy 3 (DcR3) UC specimens cell lines, examined cytotoxic effect an anti-Fas-activating monoclonal antibody (mAb) vitro. Immunohistochemical...
To determine whether lectin-like oxidized low-density lipoprotein (ox-LDL) receptor 1 (LOX-1) and the soluble form of LOX-1 (sLOX-1) are novel target molecules for diagnosis treatment rheumatoid arthritis (RA).Expression ox-LDL proteins in human RA synovium was evaluated by immunohistochemistry. Human fibroblast-like synoviocytes (FLS) were assessed ox-LDL-induced expression production matrix metalloproteinase (MMP-1) MMP-3. Levels sLOX-1 plasma synovial fluid patients with RA, compared...
The hingeless plastic ankle-foot orthosis (AFO) changes stiffness largely depending on how much is trimmed around the ankle. To support proper selection of and final adjustment orthotic stiffness, correlation between posterior upright width resistance to dorsi- plantar flexion movements was measured in 30 posterior-type AFOs. varied by regularly trimming ankle nine stages. bending AFOs 15d` with measuring device described Part 1. All decreased their both proportion reduction width. maximum...
The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and thought reflect cortical processing for preparation. aim of this study examine the modulation ERD with impairment ALS patients. hand imagery was obtained from 8 patients a variety impairments. also age-matched 11 healthy control subjects same task. magnitude frequency were compared between groups characterization specific changes. significantly smaller than those subjects. Bulbar function negatively...
The "Summary of Japanese clinical practice guidelines for Bell's palsy (idiopathic facial palsy) - 2023 update edited by the Japan Society Facial Nerve Research" aims to review latest evidence regarding treatment and provide appropriate recommendations.
Abstract Caspases exist as zymogens, and are activated by various extracellular stimuli, leading to apoptosis. One such stimulus is Fas/CD95, a member of the tumor necrosis factor receptor family, providing one means cytotoxic T lymphocyte (CTL)‐mediated cell lysis. Clinical evidence has shown that administration cytokine leads regression in selected patients with renal carcinomas (RCCs). Interferon‐γ (IFN‐γ) indicates its contribution anti‐tumor activity immune cells. IFN‐γ elicits effect...
Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic mesenchymal stem cells. This chemokine regulates formation multiple organ systems during embryogenesis. However, its skeletal development remain unclear. Here we investigated SDF-1 chondrocyte differentiation. We demonstrated that protein was expressed at pre-hypertrophic hypertrophic chondrocytes newly formed endochondral callus rib fracture as well growth...
Twelve different prosthetic feet were tested by 10 male subjects with right below-knee amputations. Level walking each foot was investigated using a pair of force plates. Five parameters selected to compare the functional characteristics feet: 1) step length, 2) velocity on sound side in relation side, 3) depth valley pattern vertical component floor reaction force, 4) efficiency deceleration and acceleration foot, 5) irregular patterns wave form fore aft components force. Each above rated...
For paraplegics, two major disadvantages of hip-knee-ankle-foot orthotic systems that have a medial single hip joint are the short stride and horizontal rotation pelvis. The authors consider pelvic is caused by factors; one lack mechanism to assist flexion, other fixed ankle joints cause instability when step length becomes longer. Users must rotate their pelvis initiate swing in legs achieve stability making as parallel possible order avoid losing balance. To overcome those disadvantages,...
Previous research has shown that low-frequency repetitive transcranial magnetic stimulation over the primary motor area and supplementary can reduce L-dopa-induced dyskinesias in Parkinson's disease; however, it involved only patients with peak-dose or diphasic dyskinesia. We report a case of patient severely painful off-period dystonia unilateral lower limb who underwent 0.9-Hz subthreshold contralateral area. Repetitive significantly reduced walking disturbances but did not. The cortical...
Abstract The treatment for lymph node involvement (LNI) after radical prostatectomy (RP) has not been established. This study aimed to reveal the outcomes of various management strategies among patients with LNI RP. Retrospectively, 561 pelvic dissection (PLND) RP treated between 2006 and 2019 at 33 institutions participating in Japanese Urological Oncology Group were investigated. Metastasis‐free survival (MFS) was primary outcome. Patients stratified by prostate‐specific antigen (PSA)...
A device was developed to measure the dorsi- and plantar flexion moment of plastic ankle-foot orthoses when deflected. It is operated by manually controlling a lever which used apply nearly static force. Various can be classified according characteristics correcting force measured this device. Simplicity high reproducibility are major advantages. However, obtain measurements approximating under wearing conditions its use restricted made low-viscosity materials.
To assess the utility, safety and feasibility of laparoscopic adrenalectomy (LA) for pheochromocytoma. We reviewed our experience, focusing on surgical outcomes compared with historical open (OA) modifications in procedures.Between 1997 2007, 23 patients pheochromocytoma underwent LA at institution. As controls, 18 undergoing OA were examined retrospectively. In first cases LA, we used an abdominal wall-lifting device low pneumoperitoneal pressure initial ligation adrenal vein. subsequent...
Objective To estimate the outcomes of high‐dose‐rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by National Comprehensive Cancer Network. Methods Between June 2009 and September 2015, 66 meeting criteria for high‐risk disease received (2 fractions 9 Gy) a boost (13 3 Gy). Androgen deprivation therapy was administered approximately years. Biochemical failure assessed using Phoenix definition. Results The...
Transrectal ultrasound (TRUS) guided prostate biopsy is standard diagnostic procedure for cancer (PCa). However, possibility of dissemination cells by not negligible. To investigate this possibility, we examined specific antigen (PSA)-bearing in peripheral blood the 108 patients before and after biopsy. Peripheral samples were obtained from with elevated serum PSA (sPSA) levels, who had undergone sextant using TRUS. The presence PSA-mRNA bearing was nested RT-PCR method enabling detection...