A5070125013- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Urinary and Genital Oncology Studies
- Cancer Cells and Metastasis
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Genital Health and Disease
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Trauma and Emergency Care Studies
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Proteoglycans and glycosaminoglycans research
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
Aichi Cancer Center
2022-2025
Mie University
2013-2024
Mie University Hospital
2018-2023
NIHR Birmingham Biomedical Research Centre
2021
Urology Foundation
2021
University of Birmingham
2020-2021
Yorkshire Cancer Research
2021
Association for Cancer Surgery
2021
Keio University
1993-2021
Institut de Virologie
2020
603 Background: Datopotamab deruxtecan (Dato-DXd) is an antibody-drug conjugate consisting of a humanized anti-TROP2 IgG1 monoclonal antibody covalently linked to highly potent topoisomerase I inhibitor payload via plasma-stable, tumor-selective, tetrapeptide-based cleavable linker. Dato-DXd has shown encouraging antitumor activity and manageable safety profile in patients (pts) with solid tumors. We report preliminary results pts advanced/metastatic (a/m) urothelial cancer from the ongoing...
Introduction Granulocyte colony‐stimulating factor‐associated aortitis remains poorly understood among clinicians. Case presentation We present a case of G‐CSF‐associated in 70‐year‐old male with stage IVb castration‐resistant prostate cancer (cT3bN0M1b) receiving docetaxel chemotherapy. Neutropenia (280/μL) developed on day 8 the first chemotherapy cycle, prompting subcutaneous administration filgrastim, short‐acting G‐CSF, days 8–10. On 14, patient presented to outpatient clinic fever but...
In the tumor microenvironment, carcinoma-associated fibroblasts (CAFs) are considered to play a critical role in promotion of tumorigenesis. However, mechanisms that generate CAFs not well elucidated. To understand how generated during primary cancer progression, we investigated biochemical characteristics normal human prostate stromal cells (PrSC) co-cultured with (PCa) vitro. cultures PCa-derived (PCaSC-8 and PCaSC-9), expression TNC, ACTA2, EGF, FGF7, IGF1 mRNA was generally higher than...
Background The reduced androgen‐sensitivity of prostate cancer (PCa) cells is an important clinical development because its association with the cells’ progression to castration‐resistant (CRPC). During androgen deprivation therapy (ADT), stroma‐derived growth factors and cytokines can activate receptor (AR). For example, IL‐6 a multifunctional cytokine that involved in malignancy PCa through AR activation. In present study, we used androgen‐sensitive human cell line (LNCaP) sublines...
Introduction Cutaneous ureterostomy is beneficial for older patients in a hypoalimentation state, providing less invasive options than intestinal tract reconstruction techniques. However, complications such as ileus and stoma site hernia still pose risks owing to the anatomical location of ureter. We introduce novel method, complete retroperitoneal cutaneous ureterostomy, performed simultaneously with robot‐assisted radical cystectomy. Case presentation Our technique involves extending space...
Abstract The treatment for lymph node involvement (LNI) after radical prostatectomy (RP) has not been established. This study aimed to reveal the outcomes of various management strategies among patients with LNI RP. Retrospectively, 561 pelvic dissection (PLND) RP treated between 2006 and 2019 at 33 institutions participating in Japanese Urological Oncology Group were investigated. Metastasis‐free survival (MFS) was primary outcome. Patients stratified by prostate‐specific antigen (PSA)...
Renal cell carcinoma (RCC) is an angiogenesis-dependent and hypoxia-driven malignancy. As a result, several targeting agents are being investigated. However, the efficacy of current regimens generally insufficient for their toxicity poor overall response rates. We have recently reported that naftopidil exerts growth-inhibitory effects on human prostate cancer cells. In this study, we investigated biochemical mechanisms by which produces antiangiogenic RCC. first tested proliferation ACHN...
The prostate gland is unique in that it undergoes rapid regression following castration but regenerates completely once androgens are replaced. Residual ductal components play an important role the regeneration of a fully functional prostate. In this study, to examine how androgen status affects structure and components, we conducted histopathological studies involuted regenerated mouse dorsolateral (DLP). castrated DLP, number luminal epithelial cells decreased time-dependent manner. On Day...
Pirfenidone (PFD) is an anti-fibrotic drug used to treat idiopathic pulmonary fibrosis by inducing G₁ cell cycle arrest in fibroblasts. We hypothesize that PFD can induce different types of cells, including cancer cells. To investigate the effects treatment on growth human prostate (PCa) we androgen-sensitive PCa line (LNCaP) and its sublines (androgen-low-sensitive E9 F10 cells androgen-insensitive AIDL cells), as well (PC-3). suppressed all Transforming factor β1 secretion was...
Robot-assisted radical cystectomy (RARC) with urinary diversion has become a standard surgical procedure because of its three-dimensional high-definition field view, flexibility, and stability. However, the highly complex steps surgery, postoperative complications cannot be ignored.
Abstract This study was designed to assess the intraoperative and postoperative benefits of two techniques for treating renal cell carcinoma (portless endoscopic surgery with radical nephrectomy [PLES‐RN] laparoscopic [LRN]) carried out at a single center. Radical either PLES‐RN (14 cases) or LRN (15 on 29 patients cT1 carcinoma. There were no statistically significant between‐group differences in patient characteristics (except tumor side), operation time, amount blood loss (χ 2 Fisher's...
Introduction Adenocarcinoma of the rete testis is a rare malignancy with poor prognosis. We report case adenocarcinoma durable response to cisplatin‐based chemotherapy. Case presentation A 48‐year‐old man Down syndrome (trisomy 21) presented 1‐month history painless swelling left scrotum. The physical examination revealed hydrocele associated tumor and enlarged pelvic para‐aortic lymph nodes. He underwent radical orchiectomy. specimen was diagnosed as testis. patient received 7 cycles...
Primary adenocarcinoma of the urinary tract producing tumor markers is extremely rare. We report 2 cases advanced carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) and 125 (CA125), which were completely resected after induction chemotherapy with paclitaxel carboplatin. Patient 1 was a 72-year-old woman right renal pelvis ureter. 73-year-old bladder. Serum levels CEA, CA19-9 CA125 elevated in both cases. They successfully treated puls carboplatin followed by surgery. Both patients...