A5049725660- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Insect Pest Control Strategies
- Genomics, phytochemicals, and oxidative stress
- Telomeres, Telomerase, and Senescence
- Agricultural pest management studies
- Plant Pathogens and Fungal Diseases
- Free Radicals and Antioxidants
- Histone Deacetylase Inhibitors Research
- Plant Disease Resistance and Genetics
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Plant Virus Research Studies
- Alzheimer's disease research and treatments
- Banana Cultivation and Research
- Drug Transport and Resistance Mechanisms
- Agricultural Economics and Practices
- Agricultural Practices and Plant Genetics
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Phytoestrogen effects and research
- Electrochemical Analysis and Applications
Chhatrapati Shahu Ji Maharaj University
2022-2024
Assam Agricultural University
2024
Cedars-Sinai Medical Center
2013-2022
Manipal University Jaipur
2019-2021
University of Allahabad
2020
Nihon University
2009-2015
Institute of Medical Sciences
2014
Central Drug Research Institute
1998-2010
Council of Scientific and Industrial Research
2010
Cancer Genetics (United States)
2009
Abstract Communication between cancer cells and the tumor microenvironment results in modulation of complex signaling networks that facilitate progression. Here, we describe a new mechanism intercellular communication originating from large oncosomes (LO), which are cell–derived, atypically (1–10 μm) extracellular vesicles (EV). We demonstrate that, context prostate cancer, LO harbor sustained AKT1 kinase activity, nominating them as active platforms. Active was detected circulating EV...
Prostate cancer is an androgen-dependent disease subject to interactions between the tumor epithelium and its microenvironment. Here, we found that epigenetic changes in prostatic cancer-associated fibroblasts (CAF) initiated a cascade of stromal-epithelial interactions. This facilitated lethal prostate growth development resistance androgen signaling deprivation therapy (ADT). We identified Ras inhibitor, RASAL3, as epigenetically silenced human CAF, leading oncogenic activity driving...
Identification of factors that mediate visceral and bone metastatic spread subsequent remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor negatively regulates cell-cycle inhibitor p21, plays critical roles during embryonic development, recent studies have highlighted its role Here, we report TBX2 overexpressed cancer specimens metastases from xenograft mouse models Blocking endogenous...
( Cancer Sci 2010; 101: 759–766) Matrix metalloproteinase (MMP)‐9, the 92‐kDa type IV collagenase, contributes to tumor invasion and metastases, strategies down‐regulate its expression could ultimately be of clinical utility. A pyrrole‐imidazole (PI) polyamide that targets activator protein‐1 (AP‐1)‐binding site MMP‐9 promoter was designed synthesized as a gene‐silencing agent for metastases. The product showed selective DNA binding ability. PI significantly inhibited MMP‐9’s mRNA...
Muscle inflammation is often associated with its expansion. Bladder smooth muscle inflammation-induced cell death accompanied by hyperplasia and hypertrophy as the primary cause for poor bladder function. In mice, DNA damage initiated chemotherapeutic drug cyclophosphamide activated caspase 1 through formation of NLRP3 complex resulting in detrusor hyperplasia. A metabolite, acrolein, caused global methylation accumulation a mouse model cultured cells. correlation, expression was...
Isoniazid (INH) is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. However it has serious limitation being hepatotoxic. Delineating mechanism underlying INH-induced hepatotoxicity may be beneficial devising ways to counteract its toxic manifestations. Studies human hepatoma HepG2 cells have indicated that INH exposure causes induction apoptosis. This study was aimed at identifying key components/pathways apoptotic pathway using cells. were...
Radiation therapy is the primary intervention for nearly half of patients with localized advanced prostate cancer and standard care recurrent disease following surgery. The development radiation-resistant an obstacle 30-50% undergoing radiotherapy. A better understanding mechanisms that lead to radiation resistance could aid in sensitizing agents improve outcome. Here we identified a radiation-resistance pathway mediated by CD105, downstream BMP TGF-β signaling. Antagonizing CD105-dependent...
Heavy metal contamination is an alarming concern on a global scale, as drinking tainted water significantly increases human susceptibility to heavy metals. In realistic scenario, humans are often exposed combination of harmful chemicals rather than single toxicant. Phloretin (PHL), biochanin-A (BCA), and coenzyme Q10 (CoQ10) bioactive compounds owning plentiful pharmacological properties. Henceforth, the current research explored putative energizing effects selected nutraceuticals in...
Hemorrhagic cystitis is an inflammatory and ulcerative bladder condition associated with systemic chemotherapeutics, like cyclophosphomide. Earlier, we reported reactive oxygen species resulting from cyclophosphamide metabolite, acrolein, causes global methylation followed by silencing of DNA damage repair genes. Ogg1 (8-oxoguanine glycosylase) one such silenced base excision enzyme that can restore integrity. The accumulation results in subsequent inflammation pyroptotic death smooth muscle...
// Manisha Tripathi 1, * , Srinivas Nandana Sandrine Billet 1 Karen A. Cavassani Rajeev Mishra Leland W.K. Chung Edwin M. Posadas and Neil Bhowmick 2 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA Research, Greater Angeles Veterans Administration, These authors have contributed equally to this work Correspondence to: Bhowmick, email: neil.bhowmick@cshs.org Posadas, Edwin.Posadas@cshs.org Keywords: carcinoma associated fibroblasts, cabozantinib,...
Significance The work provides a conceptual advance in functionally defining the cross talk of tumor epithelia with cancer-associated fibroblastic cells contributing to progression and therapeutic resistance. Independent protein-based signaling molecules, prostate cancer secreted mitochondrial DNA induce associated fibroblasts generate anaphylatoxin C3a support positive feedback loop. Interestingly, standard care chemotherapy, docetaxel, used treat castrate-resistant was found further...