A5101836997- Prostate Cancer Treatment and Research
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Immune cells in cancer
- Chromium effects and bioremediation
- Plant-Microbe Interactions and Immunity
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Plant Pathogens and Fungal Diseases
- Nematode management and characterization studies
- Hormonal and reproductive studies
- Xenotransplantation and immune response
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Proteoglycans and glycosaminoglycans research
- Forensic Entomology and Diptera Studies
- Heavy metals in environment
- Metal and Thin Film Mechanics
- Cancer, Stress, Anesthesia, and Immune Response
Texas Tech University
2018-2024
Texas Tech University Health Sciences Center
2018-2024
Chhatrapati Shahu Ji Maharaj University
2011-2023
Cedars-Sinai Medical Center
2012-2020
Govind Ballabh Pant University of Agriculture and Technology
2005-2016
National Botanical Research Institute
2011
Vanderbilt University Medical Center
2008-2010
Vanderbilt University
2007-2009
National Institute of Immunology
2007
Prostate cancer is an androgen-dependent disease subject to interactions between the tumor epithelium and its microenvironment. Here, we found that epigenetic changes in prostatic cancer-associated fibroblasts (CAF) initiated a cascade of stromal-epithelial interactions. This facilitated lethal prostate growth development resistance androgen signaling deprivation therapy (ADT). We identified Ras inhibitor, RASAL3, as epigenetically silenced human CAF, leading oncogenic activity driving...
Abstract Periodontal diseases can lead to chronic inflammation affecting the integrity of tooth supporting tissues. Recently, a striking association has been made between periodontal and primary cancers in absence mechanistic understanding. Here we address effect (PI) on tumor progression, metastasis, possible underlining mechanisms. We show that an experimental model PI mice promote lymph node (LN) micrometastasis, as well head neck metastasis 4T1 breast cancer cells, both early late stages...
Hepsin, a cell surface protease, is widely reported to be overexpressed in more than 90% of human prostate tumors. Hepsin expression correlates with tumor progression, making it significant marker and target for cancer. Recently, was that cancer mouse model, hepsin up-regulation tissue promotes progression metastasis. The underlying mechanisms, however, remain largely uncharacterized. transgenic mice displayed reduced laminin-332 (Ln-332) This an intriguing cue, since proteolytic processing...
Identification of factors that mediate visceral and bone metastatic spread subsequent remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor negatively regulates cell-cycle inhibitor p21, plays critical roles during embryonic development, recent studies have highlighted its role Here, we report TBX2 overexpressed cancer specimens metastases from xenograft mouse models Blocking endogenous...
Boerhaviadiffusa (L.) also named as Punarnava is an important herbal medicine used in several traditional medical systems, such Ayurveda, Unani, and Siddha. This plant has been for its therapeutic benefits especially against inflammatory diseases liver dysfunction kidney diseases. In addition to ethnobotanical heritage, due phytochemical profile, B. diffusa exhibits promising bioactive compounds alkaloids (e.g., punarnavine), flavonoids, glycosides, rotenoids, phenolic compounds. These...
Matriptase, a type II transmembrane serine protease, has been linked to initiation and promotion of epidermal carcinogenesis in murine model, suggesting that deregulation its role epithelia contributes transformation. In human prostate cancer, matriptase expression correlates with progression. It is therefore interest determine how may contribute epithelial neoplastic One approach for studying this identify potential substrates involved integrity and/or transformation like the extracellular...
The contamination of agricultural land with heavy metals is a global concern. Agricultural products produced in metal-contaminated soil are prone to metal accumulation, and thus, less fitted for consumption due food safety issues. cultivation biofuel crops contaminated would provide immediate economic benefit the landholders while simultaneously reclaiming sites long run. use edible soybean biodiesel production discouraged negative impact on security. However, be suitable production. In this...
Hemorrhagic cystitis is an inflammatory and ulcerative bladder condition associated with systemic chemotherapeutics, like cyclophosphomide. Earlier, we reported reactive oxygen species resulting from cyclophosphamide metabolite, acrolein, causes global methylation followed by silencing of DNA damage repair genes. Ogg1 (8-oxoguanine glycosylase) one such silenced base excision enzyme that can restore integrity. The accumulation results in subsequent inflammation pyroptotic death smooth muscle...
Abstract Background Recruited myeloid cells are known to promote cancer initiation, malignant progression, metastasis, and resistance therapy in the tumor niche. We tested hypothesis that circulating blood monocytes from advanced prostate (PCa) patients exhibit a protumor phenotype directly influence microenvironment response tumor‐derived signals. Methods Blood stable PCa were cultured, conditioned media (CM) collected analyzed using standard invasion wound closure assays measure effects on...
Deciphering the mechanisms that drive transdifferentiation to neuroendocrine prostate cancer (NEPC) is crucial identifying novel therapeutic strategies against this lethal and aggressive subtype of advanced (PCa). Further, role played by exosomal microRNAs (miRs) in mediating signaling propagate NEPC phenotype remains largely elusive. The unbiased differential miR expression profiling human PCa cells genetically modulated for TBX2 led identification miR-200c-3p. Our findings have unraveled...
// Manisha Tripathi 1, * , Srinivas Nandana Sandrine Billet 1 Karen A. Cavassani Rajeev Mishra Leland W.K. Chung Edwin M. Posadas and Neil Bhowmick 2 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA Research, Greater Angeles Veterans Administration, These authors have contributed equally to this work Correspondence to: Bhowmick, email: neil.bhowmick@cshs.org Posadas, Edwin.Posadas@cshs.org Keywords: carcinoma associated fibroblasts, cabozantinib,...
The small ruminant husbandry sector in India is not an organized like poultry, however, nowa-days many young entrepreneurs are setting up goat/sheep units using scientific rearing practices. Improving economic status, need for quality meat products, floating population of metropolis cities and changing family concept to go animal protein likely increase the requirement chevon/mutton future. intensive feeding ruminants a challenging job nutritionists this coming very fast meet increasing...
Purpose: A successful cancer surgery requires the complete removal of cancerous tissue, while also sparing as much healthy, non-cancerous tissue possible.To achieve this, an accurate identification tumor boundaries during is critical, but intra-operative visualization remains challenging.Fluorescence imaging a promising method to improve detection and delineate surgery, lack stable, long-circulating, clinically-translatable fluorescent probes that can identify tumors with high...
Laminin-332 (Ln-332) is an extracellular matrix molecule that regulates cell adhesion, spreading, and migration by interaction with surface receptors such as alpha3beta1 alpha6beta4. Previously, we developed a function-blocking monoclonal antibody against rat Ln-332, CM6, which blocks hemidesmosome assembly induced Ln-332-alpha6beta4 interactions. However, the location of its epitope on Ln-332 has remained unclear. In this study, show CM6 located laminin G-like (LG)2 module alpha3 chain. To...