A5078734873- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Esophageal and GI Pathology
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiac pacing and defibrillation studies
- Vascular Anomalies and Treatments
- Pericarditis and Cardiac Tamponade
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Treatments and Mutations
- Adrenal and Paraganglionic Tumors
- Immunodeficiency and Autoimmune Disorders
Mie University
2015-2025
Children's Hospital of Michigan
2020-2025
Wayne State University
2020-2025
Japanese Foundation For Cancer Research
2023
Osaka City General Hospital
2014-2023
Tohoku University
1989-2022
Mie University Hospital
2021
Central Michigan University
2021
Kagoshima City Hospital
2001-2019
Showa University Hospital
2019
TAS-102 consists of α, α-trifluorothymidine (TFT) and an inhibitor thymidine phosphorylase (TPI). We conducted a dose-escalation phase I study in Japanese patients with advanced solid tumours. was administered twice daily on days 1–5 8–12 28-day cycle to tumours refractory standard chemotherapy, determine its maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics (PKs). MTD evaluated 1. Safety PKs were 21 treated at 30, 40, 50, 60, or 70 mg m−2 per day. DLTs, such as...
To retrospectively evaluate the clinical outcomes of radiofrequency (RF) ablation for treatment unresectable adrenal metastasis.The institutional review board approved this retrospective study, and informed consent to perform RF was obtained from all patients. From February 2005 through May 2014, 35 patients (25 men 10 women; mean age, 64.7 years ± 9.6; age range, 39-82 years) underwent treat 41 metastatic tumors lung cancer (n = 15), renal cell carcinoma 9), colorectal 5), hepatocellular...
Abstract Introduction: Cases of Fontan failure with normal pressure have been reported. This study aimed to identify catheterisation-derived haemodynamic predictors heart transplantation/death, other than pressure, in late post-Fontan patients. Methods: retrospective evaluated patients who underwent cardiac catheterisation at age ≥10 years between 1993 and 2018. The predictive effect index-systemic vascular resistance index plot perfusion on freedom from the primary outcome (heart...
PURPOSE: To compare the diagnostic accuracy of magnetic resonance (MR) sialography with that conventional in assessment salivary gland disease Sjögren syndrome. MATERIALS AND METHODS: Thirty-five patients (32 women, three men; age range, 18-69 years) suspected having syndrome were examined MR and sialography. Gradient spin-echo was performed a 1.5-T system. sialographic findings compared findings. RESULTS: In 31 (89%) patients, stage determined accurately correlated However, at higher two...
Abstract A 23‐year‐old Japanese woman was brought to the emergency department about 6.5 h after taking liquid and later a half tablet purchased on street. About 4.5 prior presentation, she displayed excited disorganized behavior. On examination, not alert or oriented, with Glasgow Coma Scale score of 13, did answer any questions from doctors while smirking looking around restlessly, sometimes exhibited echolalia, imitating speech doctors. She given intravenous infusion fluid for 8 h, then...
Endoscopic submucosal dissection (ESD) has become a standard treatment. However, the treatment time tends to be relatively long and insufflation manipulation of endoscope can increase pain discomfort. We aimed find an optimal method for sedation during ESD.Patients scheduled undergo ESD early gastric cancer or adenoma were randomly assigned with midazolam propofol, consciousness level was evaluated by bispectral index (BIS) monitoring. Primary end points effectiveness (three parameters)...
Multicentric squamous dysplasia of the esophagus is characterized by multiple Lugol-voiding lesions (LVLs) on Lugol chromoendoscopy. Multiple LVLs are associated with a very high risk cancers arising in as well head and neck. To gain insight into pathogenesis esophageal mucosa, we studied factors for development such 76 patients who had current or previous diagnosis cell carcinoma. All underwent chromoendoscopy mucosa. The history tobacco alcohol use was documented. Polymorphisms aldehyde...
Adult ABO-incompatible liver transplantation has been known to be associated with markedly desperate outcomes. Antibody-mediated rejection (AMR) recognized as one of the primary causes these outcomes, but its clinical features and significance have not well understood. Recently, some clinicians succeeded in improving outcome adult transplantation. However, transplant patients undergoing treatments, AMR still led graft losses. We recently encountered two suffering from after remedied their...
Abstract Introduction Open thoracotomy laparotomy with extended dissection for esophageal cancer is associated problems such as delayed postoperative recovery and decreased quality of life. In contrast, in minimally invasive surgery, these can be improved. the present study, we investigated feasibility surgery cancer. Methods this retrospective evaluated esophagectomy performed by same surgeon 98 patients thoracic was 30 (open group), 68 ( MIS group). We compared invasiveness radical cure...
Transseptal puncture (TSP) has become a common approach in catheter ablation of arrhythmia originating from the left atrium. In paediatric patients, however, TSP can be challenge due to narrower access vessels and small atrial size, safety smaller children is yet understood. The purpose this study was retrospectively evaluate feasibility weighing below 30 kg.Among 655 patients who underwent between July 2009 April 2015, 43 cases having structurally normal hearts, <30 kg requiring were...
Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of pregnancy, both which caused severe yet transient (< 0·3 × 10 9 /l), probably as result transplacental maternal anti‐neutrophil autoantibodies. The antibodies seemed be against antigens other than NA1/NA2 because the autoantibodies did not bind neutrophils specific NA types selectively...
Chick embryos infected with Akabane virus by the yolk sac route at 6 days of incubation developed polymyositis and encephalitis. At 3 to 7 after inoculation, skeletal muscles had myotubule degeneration, clumping muscle cell nuclei, infiltration heterophils; dysplasia aplasia were evident 9 15 inoculation. Changes in cerebral neostriatum optic lobes 2 11 inoculation included necrosis primordial nervous tissue, hemorrhages, hyperplasia vascular endothelial cells. Cavities tissue subsequent...
Dieulafoy's lesion is an arterial malformation in the subumucosal layer of gastrointestinal tract that can cause massive bleeding. The esophagus not a common location for this lesion. We present here first report correctly diagnosed and successfully treated by endoscopic injection N-butyl-2-cyanoacrylate.
A male patient aged 67 years with chronic renal failure (CRF), who had undergone hemodialysis since June 3, complained of dyspnea while walking on 23, 1998. Rapidly progressive anemia and severe reticulocytopenia were noted. Serological tests showed that parvovirus B19- (B19) specific IgM antibody, but not IgG was present in the patient's serum. B19 DNA detected serum by polymerase chain reaction (PCR). Therefore, a definite diagnosis transient aplastic crisis induced made. On 10, prior to...
Endoscopic submucosal dissection (ESD) has recently been developed for endoscopic treatment of gastrointestinal tumors, enabling en bloc resection even large tumors [1] [2]. Although many endoscopists now perform ESD early-stage gastric cancer, yet to be established as a safe therapy colonic diseases, in Japan. It is still unclear whether indicated (SMTs), and diseases controversial issue due the considerable risk perforation. In pre-ESD era, SMTs required surgical treatment. Here we...
A 75-year-old man recovered from an episode of acute influenza. myocarditis with a normalized level serum cardiac troponin T, but less than 2 weeks after recovery, he rapidly fell into cardiogenic shock and died fulminant myocarditis. The autopsied heart showed marked inflammatory cell infiltration that mainly consisted mononuclear cells positive for CD8, suggesting the second bout was caused by viral re-infection. (Circ J 2003; 67: 646 - 648)
Introduction Adenocarcinoma of the rete testis is a rare malignancy with poor prognosis. We report case adenocarcinoma durable response to cisplatin‐based chemotherapy. Case presentation A 48‐year‐old man Down syndrome (trisomy 21) presented 1‐month history painless swelling left scrotum. The physical examination revealed hydrocele associated tumor and enlarged pelvic para‐aortic lymph nodes. He underwent radical orchiectomy. specimen was diagnosed as testis. patient received 7 cycles...