A5050106388- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Congenital heart defects research
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Biliary and Gastrointestinal Fistulas
- Cardiac Valve Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Pelvic floor disorders treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolism and Genetic Disorders
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- COVID-19 Clinical Research Studies
- Cardiac tumors and thrombi
- Pneumonia and Respiratory Infections
Osaka City General Hospital
2013-2024
Otsu Municipal Hospital
2018-2024
Shiga University of Medical Science
1989-2024
Osaka City University Hospital
2022
National Cerebral and Cardiovascular Center
2018-2021
Hiroshima University
2020
City Hospital
2018
Kyoto Medical Center
2016
Nara City Hospital
2016
Adult and Pediatric Dermatology
2014
Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate genetic landscape LVNC identify genotype-phenotype correlations large Japanese cohort.We enrolled 206 from 2002 2017 Japan. was classified as follows: congenital heart defects, arrhythmia, dilated phenotype, or normal function. In patients, 182...
To investigate whether bacterial translocation is the causative mechanism underlying cytokine production during hemorrhagic shock.Prospective, randomized, unblinded animal study.Surgical research laboratories of Shiga University Medical Science.Male Sprague-Dawley rats.The rats were randomly divided into three groups. Each was anesthetized with pentobarbital, given a continuous infusion 0.9% saline, and monitored for blood pressure. The normoxic sham shock groups breathed room air, whereas...
Patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure within a short period during the clinical course. It is essential to predict deterioration in term. We investigated use of inflammatory markers distress three days from their analysis COVID-19 patients. This retrospective observational study included 81 patients admitted COVID-19. were divided into two groups according whether maximum fraction inspired oxygen (FiO2) for blood marker measurements was ≥0.4...
Abstract No established predictive or risk classification tool exists for the neurological outcomes of post-cardiac arrest syndrome (PCAS) in patients with in-hospital cardiac (IHCA). This study aimed to investigate whether revised therapeutic hypothermia score (rCAST), which was developed estimate prognosis PCAS out-of-hospital (OHCA), applicable IHCA. A retrospective, multicenter observational 140 consecutive adult IHCA admitted three intensive care units. The area under receiver operating...
Mitochondrial acyl-CoA dehydrogenase 9 (ACAD9) deficiency is one of the common causes respiratory chain complex I deficiency, which characterized by cardiomyopathy, lactic acidemia, and muscle weakness. Infantile cardiomyopathy most phenotype usually lethal age 5 years. Riboflavin treatment known to be effective in ~65% patients; however, remaining are unresponsive riboflavin need additional measures. In this report, we describe a patient with ACAD9 who developed progressive at 8 months age....
Case A 52‐year‐old woman was admitted to our hospital with hypotension after falling from the fifth floor of an apartment building. Contrast‐enhanced computed tomography showed liver injury extravasation contrast material hepatic artery, and extrahepatic portal venous pseudoaneurysm. Intra‐abdominal hemorrhage not observed, bleeding confined retroperitoneal space. Hepatic arteriography extravasation, while venography pseudoaneurysm but no extravasation. After transarterial embolization,...
A congenital left atrial appendage aneurysm (LAAA) is a rare cardiac malformation, that is, usually diagnosed in adulthood. It rarely prenatally. In most cases, surgical resection recommended soon after the diagnosis has been made due to risk of arrhythmia and thrombotic events. The present report describes case LAAA was prenatally asymptomatic postnatally. Imaging revealed relation airway structures around detail. patient underwent successfully at 7 months age currently healthy 5 years age.
Abstract Background Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. Some patients with DCM could manifest improvement in these abnormalities called left reverse remodeling (LVRR). However, the detailed association between genotypes clinical outcomes, including LVRR, particularly among pediatric patients, remains uncertain. Methods We prospectively enrolled from Japanese multi-institutional centers 2014...
Abstract Background: Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Methods: Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their...
Total anomalous pulmonary venous connection (TAPVC) has a low prenatal diagnostic rate. Therefore, we investigated whether Doppler waveforms with pulsatility in the veins can indicate fetal TAPVC.
ABSTRACT Purpose : This study aimed to investigate the presence of schistocytes in patients with sepsis and its association mortality organ failure. Methods We conducted a retrospective observational at Shiga University Medical Science Hospital, Japan, from January 2015 April 2021. included diagnosed or septic shock. Schistocytes were identified through daily hematological examinations. Moreover, data on rates failure based Sequential Organ Failure Assessment scores systematically collected...
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left reverse remodeling (LVRR). Currently, the detailed association between genotypes clinical outcomes, including LVRR, particularly among children, remains uncertain. Pediatric from multiple Japanese institutions recorded 2014 2023 were enrolled. We identified their DCM-related genes explored gene...
mTOR阻害薬のeverolimusは，結節性硬化症に伴う腎血管筋脂肪腫や上衣下巨細胞性星細胞腫に対する有効性が報告されているが，心臓横紋筋腫に対する報告は稀である．症例は生後10か月の男児．胎児期から両側側脳室上衣下結節と多発性心臓腫瘍を指摘され結節性硬化症（TS）と診断された．出生後，小さな心臓腫瘍は自然退縮したが，右室中隔，左室自由壁，左室心尖部の大きな腫瘍は残存した．流入路，流出路狭窄はなかった．生後3か月から難治性痙攣が出現し，頭部MRIで上衣下巨細胞性星細胞腫を認めたため，生後10か月から同腫瘍に対してeverolimusを開始した（3.0 mg/m2/日）．その結果，上衣下巨細胞性星細胞腫は縮小し，痙攣も抑制できた．心臓腫瘍は，everolimus投与後1か月で左室自由壁の腫瘍が消失し，投与後7か月で左室心尖部の腫瘍も消失した．残存した右室中隔の腫瘍もeverolimus投与前は最大23.4×16.7 mmあったものが，投与後1か月で16.1×4.3 mmまで急速に縮小した．Everolimusは，TSに合併した心臓横紋筋腫を急速に退縮させる可能性がある．
背景：18トリソミーでは先天性心疾患を高率に合併するが，その生命予後から従来は積極的な治療は行われてこなかった．目的：先天性心疾患に対して手術介入を行った18トリソミーにおいて，心不全症状の改善や在宅移行への効果および予後を検証すること．対象と方法：対象は1994年から2012年までに当院で治療した18トリソミー46例．このうち，先天性心疾患に対して手術介入を行ったのは16例で，14例はNICU入院中に在宅移行を目的に姑息術を行い（A群），2例は手術介入なしで退院後，心内修復術を行った（B群）．手術介入を行わなかったのは30例（C群）．A群，B群の心疾患の内訳，手術術式や成績，在宅移行率，退院後の予後を検討した．また在宅移行率，生命予後については，C群と比較検討を行った．結果：A群14例で，周術期死亡はなかった．全例で術後心不全症状の改善が得られ，10例（71％）は在宅移行した．退院時，経腸栄養は全例で確立されており，在宅人工呼吸管理を要した例はなかった．在宅移行できた10例中3例は現在生存中であるが，残り7例は，退院後呼吸器感染等を契機に死亡した．A群の在宅移行率は71％，C群...
新生児Marfan症候群は希少な疾患で，わが国においての文献的報告は12例に留まる．出生直後ないし乳児期早期より特徴的な外表奇形と重篤な心肺機能不全を呈し予後不良である．症例は5歳女児．日齢2に哺乳不良と嘔吐を主訴に他院に入院．クモ様指と老人様顔貌があり，心エコーにて大動脈基部拡大，僧帽弁逆流，僧帽弁逸脱が確認され，新生児Marfan症候群と診断された．日齢26に当科に紹介され，生後1ヵ月よりpropranolol，生後2ヵ月よりlosartanの内服を開始．さらに，利尿薬，アンジオテンシン変換酵素阻害薬を併用していたが僧帽弁閉鎖不全が進行し，5歳時に僧帽弁置換術が施行された．また，経過中，側彎の進行と水晶体亜脱臼がみられた．遺伝子検査でFBN1遺伝子の変異［Gly1013Arg］が認められた．手術所見では，僧帽弁は弁尖が全体に肥厚し，粘液腫様変性を呈していた．弁尖，弁下組織は切除し，St. Jude Medical valve 25...
症例は保存期腎不全のため泌尿器科通院中の89歳の女性で, 突然の腹痛で当院救急外来を受診した. 腹部所見は板状硬で腹部全体の圧痛, 反跳痛を認めた. 胸部・腹部単純写真で大量のfree airを認めた. 上部消化管内視鏡で胃十二指腸穿孔が否定できたので, 下部消化管穿孔の診断で緊急開腹手術を施行した. 腹腔内全体に黄褐色の汚染腹水を多量に認め, SD-junction近傍のS状結腸前壁に7mm径の穿孔を確認した. 結腸全体に硬い宿便を認めた. 結腸憩室は確認されず, また異物・腫瘍も認めなかった. 腹腔洗浄ドレナージを行った後, 穿孔部のS状結腸を挙上し左下腹部に人工肛門を造設した. 術後は敗血症・急性肺障害のために長期間にわたる集中治療が必要であった. 慢性腎不全患者は水分制限や投薬ために恒常的に便秘になることが多く, 宿便性大腸穿孔の高リスク群と考えられる. 腹部症状に十分な注意を払う必要があると考えられた.
AIM: The recommended treatment for acute cholecystitis is early laparoscopic cholecystectomy (LC) within 72 hours after onset of symptoms. However, palliative using percutaneous transhepatic gallbladder drainage (PTGBD) often chosen clinical and logistical reasons, including difficulty performing surgery due to manpower constraints. goal this study was investigate the significance PTGBD on outcome patients with in our hospital. MATERIALS AND METHODS: Relationships between preoperative status...
Abstract Background Rectovaginal fistula (RVF) after low anterior resection for rectal cancer is troublesome and refractory. Although various surgical procedures have been previously described, no definitive procedure has shown a satisfactory outcome. We present two consecutive Japanese patients who underwent successful surgery an RVF resection. Case presentation The were women (61-year-old 64-year-old). They admitted to our hospital with chief complaint of fecal discharge from the vagina...